Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN5732 | 2-Oxopomolic acid |
| 1. 2-Oxopomolic acid shows cytotoxic activity. 2. 2-Oxopomolic acid shows radical-scavenging activities similar to that of the reference antioxidant alpha-tocopherol (vitamin E). 3. 2-Oxopomolic acid shows a significant decrease in intracellular melanin content in B16-F10 cells, and in culture media melanin. | |
| BCN5733 | beta-Yohimbine |
| 1. Beta-Yohimbine has anti-plasmodial and anti-malarial activity. 2. Beta-Yohimbine has approximately twice as toxic as yohimbine and corynanthine about one fifth as toxic. 3. Beta-yohimbine has alpha-1 and alpha-2 adrenoceptor blocking activities, it has cardiovascular effects. | |
| BCN5735 | Andrographolide |
| Andrographolide is an antiinflammatory, antiviral, anti-cancer , hepatoprotective, antithrombotic, hypotensive and antiatherosclerotic drug, it can cure hyperpigmentation disorders. Andrographolide protects against chemical-induced oxidative damage by up-regulating the gene transcription and activity of antioxidant enzymes in various tissues.Andrographolide has potential as a leading compound in the prevention or treatment of obesity and insulin resistance, can ameliorate lipid metabolism and improve glucose use in mice with HFD-induced obesity. | |
| BCN5736 | Lupanine |
| 1. Lupanine improves glucose homeostasis by influencing KATP-channels of pancreatic beta cells. 2. Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. | |
| BCN5738 | Paeonol |
| Paeonol has anticancer, anti-inflammatory, antioxidant and cardiovascular protective activities, it shows a novel inhibitory role on neuroinflammation, and presents a new candidate agent for the development of therapies for inflammation-related neurodegenerative diseases. Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively; it inhibits PGE₂ synthesis and COX-2 expression, and modulates Sirtuin 1, PKCδ and c-Src signaling pathway. | |
| BCN5739 | Isorhoifolin |
| 1. Isorhoifolin has antioxidant effects. 2. Isorhoifolin displays an anti-leakage effect comparable to or greater than diosmin. 3. Isorhoifolin in Pilea microphylla (PM1) may reverse the disturbed metabolic milieu in C57BL/KsJ-db/db mice. 4. Isorhoifolin and vicenin II are main compounds of ethyl acetate fraction (EAcF) obtained from Erythrina velutina leaves, EAcF increases the cardiac contractile force by increasing the l-type calcium current and activating the adrenergic receptor pathway. | |
| BCN5740 | Costunolide |
| Costunolide has antipyretic, anti-inflammatory, anti-oxidant, anti-carcinogenic and anti-fungal activities, it possesses normo-glycemic and hypolipidemic activity. Costunolide inhibits RANKL-induced osteoclast differentiation by suppressing RANKL-mediated c-Fos transcriptional activity; it inhibits IL-1beta gene expression by blocking the activation of MAPKs and DNA binding of AP-1; it also induces the ROS-mediated mitochondrial permeability transition and resultant cytochrome c release, | |
| BCN5741 | Isosaxalin |
| 1. Isosaxalin, heraclenin and heraclenol 3'-Me ether have melanin biosynthesis inhibitory activities . | |
