Hot Natural Products & Bioactive Compounds

1. Actinine is the biosynthetic intermed, in synth. of Carnitine BDS79-T.

1. A new route to oxcarbazepine (Trileptal), the most widely prescribed antiepileptic drug, starting from commercially available 2'-aminoacetophenone and 1,2-dibromobenzene, is reported.

1. Hypotaurine is a precursor of taurine and an antioxidant, intracellular hypotaurine is mainly supplied to placental trophoblasts by transfer from extracellular fluid across the plasma membrane, and may play a role in cell protection by scavenging reactive oxygen species.
2. Hypotaurine and cysteine sulfinate have scavenging activity towards the carbonate radical anion.
3. Hypotaurine/taurine synthesis strongly inhibits cysteinesulfinate decarboxylase (pyridoxal 5'-phosphate-dependent enzyme) as well as cystathionine γ-lyase.
4. Hypotaurine and raffinose supplementation in semen extenders provide a protection of sperm parameters against cryopreservation injury.
5. Hypotaurine suppresses acute, inflammatory, and neuropathic pain, may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord, is a promising candidate for treating various pain states.

1. Taurine, a free β-amino acid with remarkable antioxidant activity, is used in Taurine-enriched beverages to boost the muscular power of athletes.
2. Taurine can attenuate nandrolone decanoate-induced poor sperm quality and testicular toxicity in rats.
3. Taurine can effectively promote chondrocyte growth and enhance accumulation of glycosaminoglycans and collagens in the conditioned media of chondrocytes, it is effective in proliferation promotion and phenotype maintenance of chondrocytes, thus, taurine may be a useful pro-chondrogenic agent for autologous chondrocyte implantation in the treatment of cartilage repair.

1. The presence of N-Methyltaurine conjugated bile acids that are resistant to bacterial attack; the excreted N-Methyltaurine could be utilized by other bacteria in cocultures.
2. N-Methyltaurine conjugated bile acids are resistant to bacterial deconjugation and dehydroxylation, and such resistance to bacterial enzymes should aid in the maintenance of high concentrations of bile acids during lipid digestion.

2-Aminoethanol (ethanolamine) can inhibit the GABA degrading enzyme GABA aminotransferase (GABA-T), it is a possible neuromodulator in the pigeon optic tectum. Strengthening of the antioxidant mechanisms by plant pretreatment with 2-aminoethanol could be helpful in the development of a broad tolerance to adverse stress conditions.

1. O-Phosphorylethanolamine coupled with aminosilanized nanodiamonds show a homogeneous interaction with the titanium substrate.

The specific growth rates of C. raciborskii cells in media treated with β-glycerol phosphate, d-glucose-6-phosphate, and (2-aminoethyl)phosphinic acid are significantly higher than those of cells grown in phosphorus free media.