Hot Natural Products & Bioactive Compounds

1. Robustine exhibits inhibition (IC 50 < or = 18.19 microM) of superoxide anion generation by human neutrophils in response to formyl- l-methionyl- l-leucyl- l-phenylalanine/cytochalasin B (FMLP/CB), suggests that it may have anti-inflammatory activity.

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1. Sprengerinin C can strongly suppress tumor angiogenesis in human umbilical vein endothelial cells, it blocks vascular endothelial growth factor receptor 2-dependent phosphoinositide 3-kinase/Akt/mTOR/matrix metalloproteinase and p38 MAPK/matrix metalloproteinase pathways,two major pathways for tumor angiogenesis; sprengerinin C also can induce HepG-2/BEL7402 cell apoptosis by activating NADPH oxidase/reactive oxygen species-dependent caspase apoptosis pathway and suppress HepG-2/BEL7402 cell growth through p53-mediated G2/M-phase arrest, suggests that sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis.

1. Torilin and torilolone show hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells,the EC50 values are 20.6 +/- 1.86 and 3.6 +/- 0.1 microM, respectively; and silybin as a positive control shows an EC50 value of 69.0 +/- 3.4 microM.

1. Taxoquinone shows significant and concentration-dependent antioxidant and free radical scavenging activities of DPPH, nitric oxide, superoxide and hydroxyl free radicals by 78.83%, 72.42%, 72.99% and 85.04%, as compared to standard compounds ascorbic acid (81.69%, 74.62%, 73% and 73.79%).
2. Taxoquinone at the concentration range of 100-3,000 ug/mL and 200-1,000 ug/mL shows potent efficacy on inhibiting α-glucosidase and tyrosinase enzymes by 9.24-51.32% and 11.14-52.32%, respectively; suggests that taxoquinone could as a novel candidate in food and medicine industry as a natural alternative medicine to prevent diabetes mellitus type-2 related disorders and as a depigmentation agent.
3. Taxoquinone (100 ug/disc) displays potential anticandidal effect against Candia albicans.
4. Taxoquinone has strong antibacterial effect, it could be used as a promising antibacterial agent in food industry to inhibit the growth of certain important foodborne pathogens.

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1. Licorisoflavan A shows weak scavenging activity against superoxide anion radical.
2. Licorisoflavan A has bactericidal effects on S. mutans UA159 at the concentration of ≥4 g/ml, it can be useful in developing oral hygiene products, such as gargling solutions and dentifrices for preventing dental caries.
3. Licorisoflavan A and licoricidin have potential for the development of novel host-modulating strategies for the treatment of cytokine and/or MMP-mediated disorders such as periodontitis.