Senna tora (originally described by Linné as Cassia tora) is a legume in the subfamily Caesalpinioideae. It grows wild in most of the tropics and is considered a weed in many places; its native range is not well known but probably South Asia. It is often confused with Chinese Senna or Sicklepod, S. obtusifolia. Ethanolic extract of seeds of Cassiatora L. and its fractions were investigated for hypolipidemic activity on triton induced hyperlipidemic profile. Ethanolic extract and its ether soluble and water soluble fraction decreased serum level of total cholesterol by 42.07, 40.77 and 71.25%, respectively. On the other hand ethanolic extract, ether soluble fraction and water soluble fraction increased the serum HDL-cholesterol level by 6.72, 17.20 and 19.18%, respectively. Ethanolic extract, ether fraction and water fraction decreased triglyceride level by 26.84, 35.74 and 38.46%, respectively.