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1,6,7-Trihydroxyxanthone

CAS# 25577-04-2

1,6,7-Trihydroxyxanthone

Catalog No. BCN5124----Order now to get a substantial discount!

Product Name & Size Price Stock
1,6,7-Trihydroxyxanthone: 5mg $748 In Stock
1,6,7-Trihydroxyxanthone: 10mg Please Inquire In Stock
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Quality Control of 1,6,7-Trihydroxyxanthone

Number of papers citing our products

Chemical structure

1,6,7-Trihydroxyxanthone

3D structure

Chemical Properties of 1,6,7-Trihydroxyxanthone

Cas No. 25577-04-2 SDF Download SDF
PubChem ID 71307364 Appearance Yellow powder
Formula C13H8O5 M.Wt 244.2
Type of Compound Xanthones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1,6,7-trihydroxyxanthen-9-one
SMILES C1=CC2=C(C(=C1)O)C(=O)C3=CC(=C(C=C3O2)O)O
Standard InChIKey SIYGDHCRSSTGRT-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 1,6,7-Trihydroxyxanthone

The herbs of Garcinia cowa

Biological Activity of 1,6,7-Trihydroxyxanthone

Description1. 1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell growth and induce apoptosis in liver cancer cells.
TargetsDNA/RNA Synthesis

1,6,7-Trihydroxyxanthone Dilution Calculator

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1,6,7-Trihydroxyxanthone Molarity Calculator

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Preparing Stock Solutions of 1,6,7-Trihydroxyxanthone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.095 mL 20.475 mL 40.95 mL 81.9001 mL 102.3751 mL
5 mM 0.819 mL 4.095 mL 8.19 mL 16.38 mL 20.475 mL
10 mM 0.4095 mL 2.0475 mL 4.095 mL 8.19 mL 10.2375 mL
50 mM 0.0819 mL 0.4095 mL 0.819 mL 1.638 mL 2.0475 mL
100 mM 0.041 mL 0.2048 mL 0.4095 mL 0.819 mL 1.0238 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 1,6,7-Trihydroxyxanthone

MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells.[Pubmed:25416134]

Apoptosis. 2015 Jan;20(1):75-82.

Traditional Chinese medicine is recently emerged as anti-cancer therapy or adjuvant with reduced side-effects and improved quality of life. In the present study, an active ingredient, 1,6,7-Trihydroxyxanthone (THA), derived from Goodyera oblongifolia was found to strongly suppress cell growth and induce apoptosis in liver cancer cells. MicroRNAs are a group of small non-coding RNAs that regulate gene expression at post-transcriptional levels. Our results demonstrated that miR-218 was up-regulated and oncogene Bmi-1 was down-regulated by THA treatment. Further investigation showed that THA-induced-miR-218 up-regulation could lead to activation of tumor suppressor P16(Ink4a) and P14(ARF), the main down-stream targets of Bmi-1. In conclusion, THA might be a potential anti-cancer drug candidate, at least in part, through the activation of miR-218 and suppression of Bmi-1 expression.

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