MayumbineCAS# 25532-45-0 |
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| Cas No. | 25532-45-0 | SDF | Download SDF |
| PubChem ID | 179460 | Appearance | Powder |
| Formula | C21H24N2O3 | M.Wt | 352.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1C2CN3CCC4=C(C3CC2C(=CO1)C(=O)OC)NC5=CC=CC=C45 | ||
| Standard InChIKey | GRTOGORTSDXSFK-XIEZEKGWSA-N | ||
| Standard InChI | InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15+,16-,19+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Rauvolfia vomitoria
| Description | 1. Mayumbine (IC50 = 76 ± 3.5 nM) potently inhibit the in vitro binding of 3H-diazepam to the benzodiazepine sites within the rat GABAA receptor complex. |
| Targets | GABA Receptor |
Mayumbine Dilution Calculator
Mayumbine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8377 mL | 14.1884 mL | 28.3768 mL | 56.7537 mL | 70.9421 mL |
| 5 mM | 0.5675 mL | 2.8377 mL | 5.6754 mL | 11.3507 mL | 14.1884 mL |
| 10 mM | 0.2838 mL | 1.4188 mL | 2.8377 mL | 5.6754 mL | 7.0942 mL |
| 50 mM | 0.0568 mL | 0.2838 mL | 0.5675 mL | 1.1351 mL | 1.4188 mL |
| 100 mM | 0.0284 mL | 0.1419 mL | 0.2838 mL | 0.5675 mL | 0.7094 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Main glucosidase conversion products of the gluco-alkaloids dolichantoside and palicoside.[Pubmed:11397430]
Phytochemistry. 2001 Jul;57(5):653-9.
The enzymatic glucose cleavage of palicoside revealed the biosynthetic pathway to akagerine, whereas the conversion of dolichantoside led to a new quaternary heteroyohimbine alkaloid named N(b)-methyl-21-beta-hydroxy-Mayumbine. The hypothetical models of reactions occurring after the conversion of both substrates are proposed. Dolichantoside and palicoside, as well as Strychnos mellodora stem bark crude ethanol extract, exhibit significant antimycotic activity against human pathogens in presence of specific glucosidase.
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