1-Benzyl-4-hydroxypiperidineCAS# 4727-72-4 |
Quality Control & MSDS
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| Cas No. | 4727-72-4 | SDF | Download SDF |
| PubChem ID | 78461 | Appearance | Powder |
| Formula | C12H17NO | M.Wt | 191.3 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1-benzylpiperidin-4-ol | ||
| SMILES | C1CN(CCC1O)CC2=CC=CC=C2 | ||
| Standard InChIKey | BPPZXJZYCOETDA-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C12H17NO/c14-12-6-8-13(9-7-12)10-11-4-2-1-3-5-11/h1-5,12,14H,6-10H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
1-Benzyl-4-hydroxypiperidine Dilution Calculator
1-Benzyl-4-hydroxypiperidine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.2274 mL | 26.137 mL | 52.2739 mL | 104.5478 mL | 130.6848 mL |
| 5 mM | 1.0455 mL | 5.2274 mL | 10.4548 mL | 20.9096 mL | 26.137 mL |
| 10 mM | 0.5227 mL | 2.6137 mL | 5.2274 mL | 10.4548 mL | 13.0685 mL |
| 50 mM | 0.1045 mL | 0.5227 mL | 1.0455 mL | 2.091 mL | 2.6137 mL |
| 100 mM | 0.0523 mL | 0.2614 mL | 0.5227 mL | 1.0455 mL | 1.3068 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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New 1-benzyl-4-hydroxypiperidine derivatives as non-imidazole histamine H3 receptor antagonists.[Pubmed:19009544]
Arch Pharm (Weinheim). 2008 Dec;341(12):762-73.
A series of 1-benzyl-4-(3-aminopropyloxy)piperidine and 1-benzyl-4-(5-aminopentyloxy)piperidine derivatives has been prepared. The 1-Benzyl-4-hydroxypiperidine derivatives obtained were evaluated for their affinities at recombinant human histamine H(3 )receptor, stably expressed in HEK 293T cells. All compounds investigated show moderate to pronounced in-vitro affinities. The most potent antagonists in this series 9b2 (hH(3)R, pK(i) = 7.09), 9b1 (hH(3)R, pK(i) = 6.78), 9b5 (hH(3)R, pK(i) = 6.99), and 9b6 (hH(3)R, pK(i )= 6.97) were also tested in vitro as H(3 )receptor antagonists - the electrically evoked contraction of the guinea-pig jejunum. The histaminergic H(1) antagonism of selected compounds 9b1, 9b2, and 9b4-9b6 was established on the isolated guinea-pig ileum by conventional methods; the pA(2) values were compared with the potency of pyrilamine. The compounds did not show any H(1) antagonistic activity (pA(2) < 4; for pyrilamine pA(2) = 9.53).
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