1-Methyl-2-nonylquinolin-4(1H)-oneCAS# 68353-24-2 |
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| Cas No. | 68353-24-2 | SDF | Download SDF |
| PubChem ID | 13967189 | Appearance | Powder |
| Formula | C19H27NO | M.Wt | 285.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1-methyl-2-nonylquinolin-4-one | ||
| SMILES | CCCCCCCCCC1=CC(=O)C2=CC=CC=C2N1C | ||
| Standard InChIKey | XIGBBPQAXHSVSN-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C19H27NO/c1-3-4-5-6-7-8-9-12-16-15-19(21)17-13-10-11-14-18(17)20(16)2/h10-11,13-15H,3-9,12H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The fruits of Evodia rutaecarpa (Juss.) Benth.
| Description | 1. 1-Methyl-2-nonylquinolin-4(1H)-one has anti-inflammatory activity, it exhibits inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1 microM. |
1-Methyl-2-nonylquinolin-4(1H)-one Dilution Calculator
1-Methyl-2-nonylquinolin-4(1H)-one Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5039 mL | 17.5193 mL | 35.0385 mL | 70.0771 mL | 87.5964 mL |
| 5 mM | 0.7008 mL | 3.5039 mL | 7.0077 mL | 14.0154 mL | 17.5193 mL |
| 10 mM | 0.3504 mL | 1.7519 mL | 3.5039 mL | 7.0077 mL | 8.7596 mL |
| 50 mM | 0.0701 mL | 0.3504 mL | 0.7008 mL | 1.4015 mL | 1.7519 mL |
| 100 mM | 0.035 mL | 0.1752 mL | 0.3504 mL | 0.7008 mL | 0.876 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa.[Pubmed:15490316]
Planta Med. 2004 Oct;70(10):904-8.
The n-hexane extract of the fruits of Evodia rutaecarpa showed a considerable inhibiting effect on leukotriene biosynthesis in human granulocytes. Bioassay-guided fractionation of the extract led to the isolation of the 5 quinolone alkaloids: 1-methyl-2-nonyl-4(1H)-quinolinone, 1-methyl-2-(6Z)-6-undecenyl-4(1H)-quinolinone, 1-methyl-2-(4Z,7Z)-4,7-tridecadienyl-4(1H)-quinolinone, evocarpine and 1-methyl-2-(6Z,9Z)-6,9-pentadecadienyl-4(1H)-quinolinone. The compounds exhibited inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1, 10.0, 10.1, 14,6 and 12.3 microM, respectively. Structure elucidation of the compounds was achieved by 1D and 2D NMR experiments and comparison of spectral data with literature data.
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