Kuwanon E

CAS# 68401-05-8

Kuwanon E

Catalog No. BCN3287----Order now to get a substantial discount!

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Kuwanon E: 5mg $213 In Stock
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Quality Control of Kuwanon E

Quality Control & MSDS

Number of papers citing our products

Chemical structure

Kuwanon E

3D structure

Chemical Properties of Kuwanon E

Cas No. 68401-05-8 SDF Download SDF
PubChem ID 6440408 Appearance Powder
Formula C25H28O6 M.Wt 424.5
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S)-2-[5-[(2E)-3,7-dimethylocta-2,6-dienyl]-2,4-dihydroxyphenyl]-5,7-dihydroxy-2,3-dihydrochromen-4-one
SMILES CC(=CCCC(=CCC1=C(C=C(C(=C1)C2CC(=O)C3=C(C=C(C=C3O2)O)O)O)O)C)C
Standard InChIKey GJFHZVPRFLHEBR-KETROQBRSA-N
Standard InChI InChI=1S/C25H28O6/c1-14(2)5-4-6-15(3)7-8-16-9-18(20(28)12-19(16)27)23-13-22(30)25-21(29)10-17(26)11-24(25)31-23/h5,7,9-12,23,26-29H,4,6,8,13H2,1-3H3/b15-7+/t23-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Kuwanon E

The root bark of Morus alba L.

Biological Activity of Kuwanon E

DescriptionKuwanon E inhibited cholinesterase enzyme in a dose-dependent manner with K_i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, respectively. Kuwanon E also inhibited the production of MUC5AC mucin induced by PMA from NCI-H292 cells,.
TargetsBChE | AChE
In vitro

Isolation of Cholinesterase-lnhibiting Flavonoids from Moras Ihou.[Reference: WebLink]

Journal of Agricultural & Food Chemistry, 2011, 59(9):4589-4596.

Cholinesterases are key enzymes that play important roles in cholinergic transmission.
METHODS AND RESULTS:
Nine flavonoids displaying cholinesterase inhibitory activity were isolated from the root bark oiMorus Ihou L., a cultivated edible plant. The isolated compounds were identified as a new flavone (1), 5'-geranyl-5,7,2',4'-tetrahydroxyflavone (2), kuwanon U (3), Kuwanon E (4), morusin (5), morusinol (6), cyclomorusin (7), neocyclomorusin (8), and kuwanon C (9). All compounds apart from compound 6 inhibited cholinesterase enzyme in a dose-dependent manner with K_i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, respectively. The new compound was char-actierized as S'-geranyl-4'-methoxv-5,7,2'-trihydroxyflavone (1). It showed the most potent inhibitory activity (K_i = 3.1 μM for AChE, K_i= 1.74 μM for BChE). Lineweaver-Burk and Dixon plots and their secondary replots indicated that flavones (5-9) with prenyl substitution on C-3 were noncompetitive inhibitors, whereas those unsubstituted (1 -4) at C-3 were mixed inhibitors of both AChE and BChE.
CONCLUSIONS:
In conclusion, this is the first study to demonstrate that alkylated flavonoids of M. lhou have potent inhibitory activities against AChE and BChE.

In vivo

Effects of Morus alba L. and Natural Products Including Morusin on In Vivo Secretion and In Vitro Production of Airway MUC5AC Mucin.[Pubmed: 25237377 ]

Tuberculosis and Respiratory Diseases, 2014, 77(2):65-72.

It is valuable to find the potential activity of regulating the excessive mucin secretion by the compounds derived from various medicinal plants. We investigated whether aqueous extract of the root bark of Morus alba L. (AMA), Kuwanon E, kuwanon G, mulberrofuran G, and morusin significantly affect the secretion and production of airway mucin using in vivo and in vitro experimental models.
METHODS AND RESULTS:
Effect of AMA was examined on hypersecretion of airway mucin in sulfur dioxide-induced acute bronchitis in rats. Confluent NCI-H292 cells were pretreated with ethanolic extract, Kuwanon E, kuwanon G, mulberrofuran G, or morusin for 30 minutes and then stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 hours. The MUC5AC mucin secretion and production were measured by enzyme-linked immunosorbent assay. AMA stimulated the secretion of airway mucin in sulfur dioxide-induced bronchitis rat model; aqueous extract, ethanolic extract, Kuwanon E, kuwanon G, mulberrofuran G and morusin inhibited the production of MUC5AC mucin induced by PMA from NCI-H292 cells, respectively.
CONCLUSIONS:
These results suggest that extract of the root bark and the natural products derived from Morus alba L. can regulate the secretion and production of airway mucin and, at least in part, explains the folk use of extract of Morus alba L. as mucoregulators in diverse inflammatory pulmonary diseases.

Kuwanon E Dilution Calculator

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Preparing Stock Solutions of Kuwanon E

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3557 mL 11.7786 mL 23.5571 mL 47.1143 mL 58.8928 mL
5 mM 0.4711 mL 2.3557 mL 4.7114 mL 9.4229 mL 11.7786 mL
10 mM 0.2356 mL 1.1779 mL 2.3557 mL 4.7114 mL 5.8893 mL
50 mM 0.0471 mL 0.2356 mL 0.4711 mL 0.9423 mL 1.1779 mL
100 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.4711 mL 0.5889 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Description

Kuwanon E is a flavonoid isolated from Morus alba, cytotoxic to human monocytic leukemic cell lines, and reduces the level of IL-1β.

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