Timosaponin AICAS# 68422-00-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 68422-00-4 | SDF | Download SDF |
| PubChem ID | 71767755 | Appearance | Powder |
| Formula | C33H54O8 | M.Wt | 578.78 |
| Type of Compound | Steroids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R,3R,4S,5R,6R)-2-(hydroxymethyl)-6-[(1R,2S,4S,5'S,6R,7S,8R,9S,12S,13S,16S,18R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-yl]oxyoxane-3,4,5-triol | ||
| SMILES | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)OC7C(C(C(C(O7)CO)O)O)O)C)C)C)OC1 | ||
| Standard InChIKey | ZNEIIZNXGCIAAL-MYNIFUFOSA-N | ||
| Standard InChI | InChI=1S/C33H54O8/c1-17-7-12-33(38-16-17)18(2)26-24(41-33)14-23-21-6-5-19-13-20(8-10-31(19,3)22(21)9-11-32(23,26)4)39-30-29(37)28(36)27(35)25(15-34)40-30/h17-30,34-37H,5-16H2,1-4H3/t17-,18-,19+,20-,21+,22-,23-,24-,25+,26-,27-,28-,29+,30+,31-,32-,33+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The rhizomes of Anemarrhena asphodeloides Bunge.
| Description | 1. Timosaponin AI can inhibit dipeptidyl peptidase-4 (DPP-4) activity in a dose-dependent manner, the DPP-4 inhibitor has been clinically used for the treatment of type 2 diabetes mellitus. |
Timosaponin AI Dilution Calculator
Timosaponin AI Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.7278 mL | 8.6389 mL | 17.2777 mL | 34.5554 mL | 43.1943 mL |
| 5 mM | 0.3456 mL | 1.7278 mL | 3.4555 mL | 6.9111 mL | 8.6389 mL |
| 10 mM | 0.1728 mL | 0.8639 mL | 1.7278 mL | 3.4555 mL | 4.3194 mL |
| 50 mM | 0.0346 mL | 0.1728 mL | 0.3456 mL | 0.6911 mL | 0.8639 mL |
| 100 mM | 0.0173 mL | 0.0864 mL | 0.1728 mL | 0.3456 mL | 0.4319 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Screening and identification of DPP-4 inhibitors from Xiaokean formula by a fluorescent probe].[Pubmed:28879738]
Zhongguo Zhong Yao Za Zhi. 2016 Apr;41(7):1241-1245.
Fluorescent bio-probes have attracted increasing attentions in studies for screening bioactive compounds from traditional Chinese medicines. In this study, a new-type fluorescent probe with the function of aggregation-induced emission (AIE) was used to screen dipeptidyl peptidase-4 (DPP-4) inhibitor from Xiaokean formula, which has been clinically used for the treatment of type 2 diabetes mellitus. Potential DPP-4 inhibitors were screened by the fluorescent probe, with diprotin A as the positive control; totally 43 components were isolated from Xiaokean formula by systematic separation. The results showed that 13 components can exert inhibitory effects on DPP-4 activity; 16 compounds were further identified by liquid chromatography-mass spectrometry (LC-MS) from those active components. The inhibitory effects of 14 compounds were further verified, while five of them showed significant inhibition against DPP-4. Salvianolicacid C, ginsenoside Rg(5) and Timosaponin AI inhibited DPP-4 activity at the concentration of 5-50 mumol*L(-)(1) in a dose-dependent manner. Thus, our study provided a successful example for screening bioactive compounds from traditional Chinese medicines by using a novelfluorescent probe.
Timosaponin A1 is a coprostane type steroidal saponin isolated from Rhizoma Anemarrhenae.
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