Isoguvacine hydrochlorideSelective GABAA agonist CAS# 68547-97-7 |
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 68547-97-7 | SDF | Download SDF |
| PubChem ID | 155107 | Appearance | Powder |
| Formula | C6H10ClNO2 | M.Wt | 163.6 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 25 mg/mL (152.81 mM; Need ultrasonic) | ||
| Chemical Name | 1,2,3,6-tetrahydropyridine-4-carboxylic acid;hydrochloride | ||
| SMILES | C1CNCC=C1C(=O)O.Cl | ||
| Standard InChIKey | SUWREQRNTXCCBL-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Specific GABAA receptor agonist. Suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices. |
Isoguvacine hydrochloride Dilution Calculator
Isoguvacine hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.1125 mL | 30.5623 mL | 61.1247 mL | 122.2494 mL | 152.8117 mL |
| 5 mM | 1.2225 mL | 6.1125 mL | 12.2249 mL | 24.4499 mL | 30.5623 mL |
| 10 mM | 0.6112 mL | 3.0562 mL | 6.1125 mL | 12.2249 mL | 15.2812 mL |
| 50 mM | 0.1222 mL | 0.6112 mL | 1.2225 mL | 2.445 mL | 3.0562 mL |
| 100 mM | 0.0611 mL | 0.3056 mL | 0.6112 mL | 1.2225 mL | 1.5281 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures.[Pubmed:19535226]
Epilepsy Res. 2009 Oct;86(2-3):113-23.
PURPOSE: Seizure like events (SLEs) induced by low magnesium or 4-aminopyridine in organotypic hippocampal slice cultures (OHSCs) are resistant to standard antiepileptic drugs including phenobarbital, and 1,4-benzodiazepines [Albus, K., Wahab, A., Heinemann, U., 2008. Standard antiepileptic drugs fail to block epileptiform activity in rat organotypic hippocampal slice cultures. Br. J. Pharmacol. 154, 709-724]. The present study was undertaken in order to test the effects of other compounds on SLEs in OHSCs that enhance GABA-mediated actions. METHODS: Six to 12 days old Wistar rats were used to cultivate OHSCs according to the interface method [Stoppini, L., Buchs, P.A., Muller, D., 1991. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 37, 173-182]. Neuronal activity and extracellular potassium concentration were recorded under submerged conditions. SLEs were induced by lowering the magnesium concentration. The effects of GABA(A) agonists muscimol and isoguvacine, the GABA(B) agonist baclofen, the GABA uptake blocker nipecotic acid and the neurosteroid alfaxalone on induction and ongoing SLEs were analyzed. RESULTS: Low magnesium induced SLEs were dose dependently suppressed by the GABA(A) receptor agonists muscimol, isoguvacine and alfaxalone and by the GABA uptake inhibitor nipecotic acid whereas the GABA(B) receptor agonist baclofen attenuated but did not suppress SLE. DISCUSSION: Our findings demonstrate that in OHSCs GABA has an inhibitory effect on SLEs. Proconvulsant effects of GABA agonists on spontaneous neuronal activity and seizure like activity were never observed. Our findings exclude a possible contribution of impaired/altered GABA-ergic mechanisms based on immaturity of receptors and/or low receptor density to seizure susceptibility and pharmacoresistance in OHSCs.
