Isoguvacine hydrochloride

Selective GABAA agonist CAS# 68547-97-7

Isoguvacine hydrochloride

Catalog No. BCC6575----Order now to get a substantial discount!

Product Name & Size Price Stock
Isoguvacine hydrochloride: 5mg $12 In Stock
Isoguvacine hydrochloride: 10mg Please Inquire In Stock
Isoguvacine hydrochloride: 20mg Please Inquire Please Inquire
Isoguvacine hydrochloride: 50mg Please Inquire Please Inquire
Isoguvacine hydrochloride: 100mg Please Inquire Please Inquire
Isoguvacine hydrochloride: 200mg Please Inquire Please Inquire
Isoguvacine hydrochloride: 500mg Please Inquire Please Inquire
Isoguvacine hydrochloride: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Isoguvacine hydrochloride

Number of papers citing our products

Chemical structure

Isoguvacine hydrochloride

3D structure

Chemical Properties of Isoguvacine hydrochloride

Cas No. 68547-97-7 SDF Download SDF
PubChem ID 155107 Appearance Powder
Formula C6H10ClNO2 M.Wt 163.6
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 25 mg/mL (152.81 mM; Need ultrasonic)
Chemical Name 1,2,3,6-tetrahydropyridine-4-carboxylic acid;hydrochloride
SMILES C1CNCC=C1C(=O)O.Cl
Standard InChIKey SUWREQRNTXCCBL-UHFFFAOYSA-N
Standard InChI InChI=1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Isoguvacine hydrochloride

DescriptionSpecific GABAA receptor agonist. Suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.

Isoguvacine hydrochloride Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Isoguvacine hydrochloride Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Isoguvacine hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.1125 mL 30.5623 mL 61.1247 mL 122.2494 mL 152.8117 mL
5 mM 1.2225 mL 6.1125 mL 12.2249 mL 24.4499 mL 30.5623 mL
10 mM 0.6112 mL 3.0562 mL 6.1125 mL 12.2249 mL 15.2812 mL
50 mM 0.1222 mL 0.6112 mL 1.2225 mL 2.445 mL 3.0562 mL
100 mM 0.0611 mL 0.3056 mL 0.6112 mL 1.2225 mL 1.5281 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Isoguvacine hydrochloride

Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures.[Pubmed:19535226]

Epilepsy Res. 2009 Oct;86(2-3):113-23.

PURPOSE: Seizure like events (SLEs) induced by low magnesium or 4-aminopyridine in organotypic hippocampal slice cultures (OHSCs) are resistant to standard antiepileptic drugs including phenobarbital, and 1,4-benzodiazepines [Albus, K., Wahab, A., Heinemann, U., 2008. Standard antiepileptic drugs fail to block epileptiform activity in rat organotypic hippocampal slice cultures. Br. J. Pharmacol. 154, 709-724]. The present study was undertaken in order to test the effects of other compounds on SLEs in OHSCs that enhance GABA-mediated actions. METHODS: Six to 12 days old Wistar rats were used to cultivate OHSCs according to the interface method [Stoppini, L., Buchs, P.A., Muller, D., 1991. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 37, 173-182]. Neuronal activity and extracellular potassium concentration were recorded under submerged conditions. SLEs were induced by lowering the magnesium concentration. The effects of GABA(A) agonists muscimol and isoguvacine, the GABA(B) agonist baclofen, the GABA uptake blocker nipecotic acid and the neurosteroid alfaxalone on induction and ongoing SLEs were analyzed. RESULTS: Low magnesium induced SLEs were dose dependently suppressed by the GABA(A) receptor agonists muscimol, isoguvacine and alfaxalone and by the GABA uptake inhibitor nipecotic acid whereas the GABA(B) receptor agonist baclofen attenuated but did not suppress SLE. DISCUSSION: Our findings demonstrate that in OHSCs GABA has an inhibitory effect on SLEs. Proconvulsant effects of GABA agonists on spontaneous neuronal activity and seizure like activity were never observed. Our findings exclude a possible contribution of impaired/altered GABA-ergic mechanisms based on immaturity of receptors and/or low receptor density to seizure susceptibility and pharmacoresistance in OHSCs.

Description

Isoguvacine hydrochloride is a GABA receptor agonist.

Keywords:

Isoguvacine hydrochloride,68547-97-7,Natural Products,GABA Receptor, buy Isoguvacine hydrochloride , Isoguvacine hydrochloride supplier , purchase Isoguvacine hydrochloride , Isoguvacine hydrochloride cost , Isoguvacine hydrochloride manufacturer , order Isoguvacine hydrochloride , high purity Isoguvacine hydrochloride

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: