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11-Hydroxy-12-methoxyabietatriene

CAS# 16755-54-7

11-Hydroxy-12-methoxyabietatriene

Catalog No. BCN3253----Order now to get a substantial discount!

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Quality Control of 11-Hydroxy-12-methoxyabietatriene

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Chemical structure

11-Hydroxy-12-methoxyabietatriene

3D structure

Chemical Properties of 11-Hydroxy-12-methoxyabietatriene

Cas No. 16755-54-7 SDF Download SDF
PubChem ID 14827262 Appearance Cryst.
Formula C21H32O2 M.Wt 316.5
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (4bS,8aS)-3-methoxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenanthren-4-ol
SMILES CC(C)C1=C(C(=C2C(=C1)CCC3C2(CCCC3(C)C)C)O)OC
Standard InChIKey NCQBQRRNDYBXHO-KKSFZXQISA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 11-Hydroxy-12-methoxyabietatriene

The herbs of Salvia candidissima

Biological Activity of 11-Hydroxy-12-methoxyabietatriene

Description11-Hydroxy-12-methoxyabietatriene is a natural product from Salvia candidissima.
In vitro

Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.[Pubmed: 15969497 ]

J Agric Food Chem. 2005 Jun 29;53(13):5200-6.


METHODS AND RESULTS:
The new diterpenes brussonol (1) and iguestol (6alpha,11-dihydroxy-12-methoxy-abieta-8,11,13-triene) (2) with an icetexane and a dehydroabietane skeleton, respectively, have been isolated from hairy root cultures of Salvia broussonetii. Other previously known diterpenes, 7-oxodehydroabietane, 11-Hydroxy-12-methoxyabietatriene, taxodione, inuroyleanol, ferruginol, deoxocarnosol 12-methyl ether, cryptojaponol, pisiferal, sugiol, isomanool, 14-deoxycoleon U, 6alpha-hydroxydemethylcryptojaponol, demethylsalvicanol, and demethylcryptojaponol, were also obtained from these roots. The insect antifeedant and toxic effects of several of these compounds were investigated against the insect pests Spodoptera littoralis and Leptinotarsa decemlineata. Additionally, their comparative cytotoxic effects were tested on insect Sf9 and mammalian CHO cells. Demethylsalvicanol (4) was a moderate antifeedant to L. decemlineata, whereas brussonol (1) was inactive. 14-Deoxycoleon U (15) was the strongest antifeedant, whereas demethylcryptojaponol (11) was toxic to this insect.
CONCLUSIONS:
None of these compounds had antifeedant or negative effects on S. littoralis ingestion or weight gains after oral administration. Demethylcryptojaponol (11) was cytotoxic to mammalian CHO and insect Sf9 cell lines, followed by the icetexane derivative brussonol (1), with moderate cytotoxicity in both cases. The remainder of the test compounds showed a strong selective cytotoxicty to insect Sf9 cells, with demethylsalvicanol (4) being the most active.

11-Hydroxy-12-methoxyabietatriene Dilution Calculator

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11-Hydroxy-12-methoxyabietatriene Molarity Calculator

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Preparing Stock Solutions of 11-Hydroxy-12-methoxyabietatriene

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1596 mL 15.7978 mL 31.5956 mL 63.1912 mL 78.9889 mL
5 mM 0.6319 mL 3.1596 mL 6.3191 mL 12.6382 mL 15.7978 mL
10 mM 0.316 mL 1.5798 mL 3.1596 mL 6.3191 mL 7.8989 mL
50 mM 0.0632 mL 0.316 mL 0.6319 mL 1.2638 mL 1.5798 mL
100 mM 0.0316 mL 0.158 mL 0.316 mL 0.6319 mL 0.7899 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 11-Hydroxy-12-methoxyabietatriene

Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.[Pubmed:15969497]

J Agric Food Chem. 2005 Jun 29;53(13):5200-6.

The new diterpenes brussonol (1) and iguestol (6alpha,11-dihydroxy-12-methoxy-abieta-8,11,13-triene) (2) with an icetexane and a dehydroabietane skeleton, respectively, have been isolated from hairy root cultures of Salvia broussonetii. Other previously known diterpenes, 7-oxodehydroabietane, 11-Hydroxy-12-methoxyabietatriene, taxodione, inuroyleanol, ferruginol, deoxocarnosol 12-methyl ether, cryptojaponol, pisiferal, sugiol, isomanool, 14-deoxycoleon U, 6alpha-hydroxydemethylcryptojaponol, demethylsalvicanol, and demethylcryptojaponol, were also obtained from these roots. The insect antifeedant and toxic effects of several of these compounds were investigated against the insect pests Spodoptera littoralis and Leptinotarsa decemlineata. Additionally, their comparative cytotoxic effects were tested on insect Sf9 and mammalian CHO cells. Demethylsalvicanol (4) was a moderate antifeedant to L. decemlineata, whereas brussonol (1) was inactive. 14-Deoxycoleon U (15) was the strongest antifeedant, whereas demethylcryptojaponol (11) was toxic to this insect. None of these compounds had antifeedant or negative effects on S. littoralis ingestion or weight gains after oral administration. Demethylcryptojaponol (11) was cytotoxic to mammalian CHO and insect Sf9 cell lines, followed by the icetexane derivative brussonol (1), with moderate cytotoxicity in both cases. The remainder of the test compounds showed a strong selective cytotoxicty to insect Sf9 cells, with demethylsalvicanol (4) being the most active.

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