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2,3-Dihydro-3alpha-methoxynimbolide

CAS# 1607828-35-2

2,3-Dihydro-3alpha-methoxynimbolide

Catalog No. BCN7093----Order now to get a substantial discount!

Product Name & Size Price Stock
2,3-Dihydro-3alpha-methoxynimbolide: 5mg $1150 In Stock
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2,3-Dihydro-3alpha-methoxynimbolide: 500mg Please Inquire Please Inquire
2,3-Dihydro-3alpha-methoxynimbolide: 1000mg Please Inquire Please Inquire

Quality Control of 2,3-Dihydro-3alpha-methoxynimbolide

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Chemical structure

2,3-Dihydro-3alpha-methoxynimbolide

3D structure

Chemical Properties of 2,3-Dihydro-3alpha-methoxynimbolide

Cas No. 1607828-35-2 SDF Download SDF
PubChem ID 102200378 Appearance Powder
Formula C28H34O8 M.Wt 498.57
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1=C2C(CC1C3=COC=C3)OC4C2(C(C5(C6C4OC(=O)C6(C(CC5=O)OC)C)C)CC(=O)OC)C
Standard InChIKey OROAUBFPFAPQMD-LPLKPKLGSA-N
Standard InChI InChI=1S/C28H34O8/c1-13-15(14-7-8-34-12-14)9-16-21(13)27(3)17(10-20(30)33-6)26(2)18(29)11-19(32-5)28(4)23(26)22(24(27)35-16)36-25(28)31/h7-8,12,15-17,19,22-24H,9-11H2,1-6H3/t15-,16-,17-,19-,22-,23-,24-,26+,27-,28-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 2,3-Dihydro-3alpha-methoxynimbolide

The barks of Azadirachta indica

Biological Activity of 2,3-Dihydro-3alpha-methoxynimbolide

Description1. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in stomach (AZ521) cancer cell line.
TargetsBcl-2/Bax | Caspase

2,3-Dihydro-3alpha-methoxynimbolide Dilution Calculator

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2,3-Dihydro-3alpha-methoxynimbolide Molarity Calculator

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Preparing Stock Solutions of 2,3-Dihydro-3alpha-methoxynimbolide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0057 mL 10.0287 mL 20.0574 mL 40.1147 mL 50.1434 mL
5 mM 0.4011 mL 2.0057 mL 4.0115 mL 8.0229 mL 10.0287 mL
10 mM 0.2006 mL 1.0029 mL 2.0057 mL 4.0115 mL 5.0143 mL
50 mM 0.0401 mL 0.2006 mL 0.4011 mL 0.8023 mL 1.0029 mL
100 mM 0.0201 mL 0.1003 mL 0.2006 mL 0.4011 mL 0.5014 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2,3-Dihydro-3alpha-methoxynimbolide

Limonoids from Azadirachta indica var. siamensis extracts and their cytotoxic and melanogenesis-inhibitory activities.[Pubmed:24706622]

Chem Biodivers. 2014 Apr;11(4):505-31.

Six new limonoids, 7-benzoyl-17-epinimbocinol (5), 3-acetyl-7-tigloylnimbidinin (8), 1-isovaleroyl-1-detigloylsalanninolide (15), 2,3-Dihydro-3alpha-methoxynimbolide (16), deacetyl-20,21-epoxy-20,22-dihydro-21-deoxyisonimbinolide (26), and deacetyl-20,21,22,23-tetrahydro-20,22-dihydroxy-21,23-dimethoxynimbin (27), along with 28 known limonoids, 1-4, 6, 7, 9-14, 17-25, and 28-34, and two known flavonoids, 35 and 36, have been isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton (Siamese neem tree; Meliaceae). The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis and comparison with literature data. All of these compounds were evaluated for their cytotoxic activities against leukemia (HL60), lung (A549), stomach (AZ521), and breast (SK-BR-3) cancer cell lines. Eleven compounds, 1, 2, 4-7, 13, 16, 17, 29, and 30, exhibited potent cytotoxicities against one or more cell lines with IC50 values in the range of 0.1-9.3 muM. Compound 16 induced apoptotic cell death in AZ521 cells upon evaluation of the apoptosis-inducing activity by flow cytometric analysis. Western blot analysis on AZ521 cells revealed that compound 16 activated caspases-3, -8, and -9, while increasing the ratio of Bax/Bcl-2. This suggested that 16 induced apoptosis via both mitochondrial and death receptor pathways in AZ521. In addition, upon evaluation of all compounds against the melanogenesis in B16 melanoma cells induced with alpha-melanocyte-stimulating hormone (alpha-MSH), 20 limonoids, i.e., 1-3, 6, 9-11, 18, 19, 21-29, 32, and 34, and two flavonoids, 35 and 36, exhibited melanogenesis-inhibitory activities, with no, or almost no, toxicities to the cells at lower and/or higher concentrations, which were more potent than the reference arbutin, a known melanogenesis inhibitor. Western blot analysis showed that nimbin (18) reduced the protein levels of microphtalmia-associated transcription factor (MITF), tyrosinase, tyrosine-related protein 1 (TRP-1), and TRP-2 mostly in a concentration-dependent manner, indicating that 18 inhibits melanogenesis on a alpha-MSH-stimulated B16 melanoma cells by, at least in part, inhibiting the expression of MITF, followed by decreasing the expression of tyrosinase, TRP-1, and TRP-2.

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