Bisandrographolide ACAS# 160498-00-0 |
- Bisandrographolide C
Catalog No.:BCN0416
CAS No.:160498-02-2
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 160498-00-0 | SDF | Download SDF |
PubChem ID | 12000062 | Appearance | Powder |
Formula | C40H56O8 | M.Wt | 664.88 |
Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
Synonyms | bisandrographolide;Bisandrographolide C;160498-02-2 | ||
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 4-[(E)-2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethenyl]-2-[2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]-1-(5-oxo-2H-furan-4-yl)ethyl]-2H-furan-5-one | ||
SMILES | CC12CCC(C(C1CCC(=C)C2CC(C3C=C(C(=O)O3)C=CC4C(=C)CCC5C4(CCC(C5(C)CO)O)C)C6=CCOC6=O)(C)CO)O | ||
Standard InChIKey | WQHWOZANSOUSAY-LZBAHHAZSA-N | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. Bisandrographolide A activates TRPV4 channels, could play a role in some of the effects of Andrographis extract described in traditional medicine. |
Targets | TRPV |
Bisandrographolide A Dilution Calculator
Bisandrographolide A Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 1.504 mL | 7.5202 mL | 15.0403 mL | 30.0806 mL | 37.6008 mL |
5 mM | 0.3008 mL | 1.504 mL | 3.0081 mL | 6.0161 mL | 7.5202 mL |
10 mM | 0.1504 mL | 0.752 mL | 1.504 mL | 3.0081 mL | 3.7601 mL |
50 mM | 0.0301 mL | 0.1504 mL | 0.3008 mL | 0.6016 mL | 0.752 mL |
100 mM | 0.015 mL | 0.0752 mL | 0.1504 mL | 0.3008 mL | 0.376 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Antirhine
Catalog No.:BCN4003
CAS No.:16049-28-8
- THZ2
Catalog No.:BCC3986
CAS No.:1604810-84-5
- THZ1
Catalog No.:BCC4005
CAS No.:1604810-83-4
- 30-Oxopseudotaraxasterol
Catalog No.:BCN7135
CAS No.:160481-71-0
- 3',5,5',7-Tetrahydroxyflavanone
Catalog No.:BCN1710
CAS No.:160436-10-2
- X-NeuNAc
Catalog No.:BCC2063
CAS No.:160369-85-7
- Bisdehydroneotuberostemonine
Catalog No.:BCN7072
CAS No.:160333-27-7
- L-368,899 hydrochloride
Catalog No.:BCC7438
CAS No.:160312-62-9
- 8-Hydroxybergapten
Catalog No.:BCN2732
CAS No.:1603-47-0
- SB 205384
Catalog No.:BCC7095
CAS No.:160296-13-9
- 14-Deoxy-11-hydroxyandrographolide
Catalog No.:BCN4702
CAS No.:160242-09-1
- SR 11302
Catalog No.:BCC3607
CAS No.:160162-42-5
- 12S-hydroxyandrographolide
Catalog No.:BCN4700
CAS No.:869593-50-0
- BW 723C86 hydrochloride
Catalog No.:BCC6915
CAS No.:160521-72-2
- 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone
Catalog No.:BCN6847
CAS No.:1605304-56-0
- Zarzissine
Catalog No.:BCN6456
CAS No.:160568-14-9
- DMP 543
Catalog No.:BCC7331
CAS No.:160588-45-4
- Villosin
Catalog No.:BCN1711
CAS No.:160598-92-5
- 1,4,6-Trihydroxy-5-methoxy-7-prenylxanthone
Catalog No.:BCN1548
CAS No.:160623-47-2
- 2,3-Dihydro-3alpha-methoxynimbolide
Catalog No.:BCN7093
CAS No.:1607828-35-2
- Ardisicrenoside B
Catalog No.:BCN8078
CAS No.:160791-12-8
- Indirubin-3'-oxime
Catalog No.:BCC7185
CAS No.:160807-49-8
- AMG319
Catalog No.:BCC6510
CAS No.:1608125-21-8
- H-Thr(Bzl)-ol
Catalog No.:BCC2577
CAS No.:160841-03-2
Bisandrographolide from Andrographis paniculata activates TRPV4 channels.[Pubmed:16899456]
J Biol Chem. 2006 Oct 6;281(40):29897-904.
Many transient receptor potential (TRP) channels are activated or blocked by various compounds found in plants; two prominent examples include the activation of TRPV1 channels by capsaicin and the activation of TRPM8 channels by menthol. We sought to identify additional plant compounds that are active on other types of TRP channels. We screened a library of extracts from 50 Chinese herbal plants using a calcium-imaging assay to find compounds active on TRPV3 and TRPV4 channels. An extract from the plant Andrographis paniculata potently activated TRPV4 channels. The extract was fractionated further, and the active compound was identified as Bisandrographolide A (BAA). We used purified compound to characterize the activity of BAA on certain TRPV channel subtypes. Although BAA activated TRPV4 channels with an EC(50) of 790-950 nm, it did not activate or block activation of TRPV1, TRPV2, or TRPV3 channels. BAA activated a large TRPV4-like current in immortalized mouse keratinocytes (308 cells) that have been shown to express TRPV4 protein endogenously. This compound also activated TRPV4 currents in cell-free outside-out patches from HEK293T cells overexpressing TRPV4 cDNA, suggesting that BAA can activate the channel in a membrane-delimited manner. Another related compound, andrographolide, found in abundance in the plant Andrographis was unable to activate or block activation of TRPV4 channels. These experiments show that BAA activates TRPV4 channels, and we discuss the possibility that activation of TRPV4 by BAA could play a role in some of the effects of Andrographis extract described in traditional medicine.