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Bisandrographolide A

CAS# 160498-00-0

Bisandrographolide A

Catalog No. BCN4701----Order now to get a substantial discount!

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Bisandrographolide A: 5mg $1098 In Stock
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Chemical structure

Bisandrographolide A

3D structure

Chemical Properties of Bisandrographolide A

Cas No. 160498-00-0 SDF Download SDF
PubChem ID 12000062 Appearance Powder
Formula C40H56O8 M.Wt 664.88
Type of Compound Diterpenoids Storage Desiccate at -20°C
Synonyms bisandrographolide;Bisandrographolide C;160498-02-2
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-[(E)-2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethenyl]-2-[2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]-1-(5-oxo-2H-furan-4-yl)ethyl]-2H-furan-5-one
SMILES CC12CCC(C(C1CCC(=C)C2CC(C3C=C(C(=O)O3)C=CC4C(=C)CCC5C4(CCC(C5(C)CO)O)C)C6=CCOC6=O)(C)CO)O
Standard InChIKey WQHWOZANSOUSAY-LZBAHHAZSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Bisandrographolide A

The herbs of Andrographis paniculata (Burm. f.) Nees

Biological Activity of Bisandrographolide A

Description1. Bisandrographolide A activates TRPV4 channels, could play a role in some of the effects of Andrographis extract described in traditional medicine.
TargetsTRPV

Bisandrographolide A Dilution Calculator

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Bisandrographolide A Molarity Calculator

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Preparing Stock Solutions of Bisandrographolide A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.504 mL 7.5202 mL 15.0403 mL 30.0806 mL 37.6008 mL
5 mM 0.3008 mL 1.504 mL 3.0081 mL 6.0161 mL 7.5202 mL
10 mM 0.1504 mL 0.752 mL 1.504 mL 3.0081 mL 3.7601 mL
50 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.6016 mL 0.752 mL
100 mM 0.015 mL 0.0752 mL 0.1504 mL 0.3008 mL 0.376 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Bisandrographolide A

Bisandrographolide from Andrographis paniculata activates TRPV4 channels.[Pubmed:16899456]

J Biol Chem. 2006 Oct 6;281(40):29897-904.

Many transient receptor potential (TRP) channels are activated or blocked by various compounds found in plants; two prominent examples include the activation of TRPV1 channels by capsaicin and the activation of TRPM8 channels by menthol. We sought to identify additional plant compounds that are active on other types of TRP channels. We screened a library of extracts from 50 Chinese herbal plants using a calcium-imaging assay to find compounds active on TRPV3 and TRPV4 channels. An extract from the plant Andrographis paniculata potently activated TRPV4 channels. The extract was fractionated further, and the active compound was identified as Bisandrographolide A (BAA). We used purified compound to characterize the activity of BAA on certain TRPV channel subtypes. Although BAA activated TRPV4 channels with an EC(50) of 790-950 nm, it did not activate or block activation of TRPV1, TRPV2, or TRPV3 channels. BAA activated a large TRPV4-like current in immortalized mouse keratinocytes (308 cells) that have been shown to express TRPV4 protein endogenously. This compound also activated TRPV4 currents in cell-free outside-out patches from HEK293T cells overexpressing TRPV4 cDNA, suggesting that BAA can activate the channel in a membrane-delimited manner. Another related compound, andrographolide, found in abundance in the plant Andrographis was unable to activate or block activation of TRPV4 channels. These experiments show that BAA activates TRPV4 channels, and we discuss the possibility that activation of TRPV4 by BAA could play a role in some of the effects of Andrographis extract described in traditional medicine.

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