AZD3264IKK2 inhibitor CAS# 1609281-86-8 |
- MK-4827
Catalog No.:BCC1761
CAS No.:1038915-60-4
- BMN-673 8R,9S
Catalog No.:BCC1422
CAS No.:1207456-00-5
- XAV-939
Catalog No.:BCC1120
CAS No.:284028-89-3
- PJ34
Catalog No.:BCC1865
CAS No.:344458-19-1
- ABT-888 (Veliparib)
Catalog No.:BCC1267
CAS No.:912444-00-9
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 1609281-86-8 | SDF | Download SDF |
PubChem ID | 91666658 | Appearance | Powder |
Formula | C21H23N5O4S | M.Wt | 441.5 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | DMSO : ≥ 48 mg/mL (108.72 mM) *"≥" means soluble, but saturation unknown. | ||
Chemical Name | 2-(carbamoylamino)-5-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(3S)-pyrrolidin-3-yl]oxyphenyl]thiophene-3-carboxamide | ||
SMILES | CC1=C(C(=NO1)C)C2=CC(=C(C=C2)C3=CC(=C(S3)NC(=O)N)C(=O)N)OC4CCNC4 | ||
Standard InChIKey | NMFIXEFNQPDISY-ZDUSSCGKSA-N | ||
Standard InChI | InChI=1S/C21H23N5O4S/c1-10-18(11(2)30-26-10)12-3-4-14(16(7-12)29-13-5-6-24-9-13)17-8-15(19(22)27)20(31-17)25-21(23)28/h3-4,7-8,13,24H,5-6,9H2,1-2H3,(H2,22,27)(H3,23,25,28)/t13-/m0/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | AZD3264 is a selective IkB-kinase IKK2 inhibitor.In Vivo:AZD3264 is a selective IkB-kinase IKK2 inhibitor, which is currently in preclinical development for the potential treatment of chronic pulmonary obstructive disorder (COPD) and asthma[1]. References: |
AZD3264 Dilution Calculator
AZD3264 Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.265 mL | 11.325 mL | 22.6501 mL | 45.3001 mL | 56.6251 mL |
5 mM | 0.453 mL | 2.265 mL | 4.53 mL | 9.06 mL | 11.325 mL |
10 mM | 0.2265 mL | 1.1325 mL | 2.265 mL | 4.53 mL | 5.6625 mL |
50 mM | 0.0453 mL | 0.2265 mL | 0.453 mL | 0.906 mL | 1.1325 mL |
100 mM | 0.0227 mL | 0.1133 mL | 0.2265 mL | 0.453 mL | 0.5663 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Target: IKK2
IC50: N/A
AZD3264 is a novel and small molecule IKK2 inhibitor.
IKK2 serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity induces the activation of a transcription factor NF-κB. Activated IKK2 phosphorylates IκB (IκBα), which binds NF-κB to inhibit its function. Phosphorylated IκB is degraded by the ubiquitination pathway, freeing NF-κB, and allowing its entry into the cell nucleus where it activates target genes involved in inflammation and other immune responses. Suppression of IKK2 has been identified as a potential therapeutic option to treat cancer and inflammatory diseases, including asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis [1].
In vitro: AZD3264, by inhibiting IKK2, was currently in preclinical development for the potential treatment of inflammatory diseases such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis [2].
In vivo: N/A
References:
1. Llona-Minguez S, Baiget J, Mackay SP. Small-molecule inhibitors of IkappaB kinase (IKK) and IKK-related kinases. Pharm Pat Anal. 2013;2(4):481-98.
2. Murugan A, et al. Org. Process Res. Dev. 2014, 18, 646-651.
- Villosin C
Catalog No.:BCN1712
CAS No.:160927-81-1
- Hosenkoside K
Catalog No.:BCN2577
CAS No.:160896-49-1
- Hosenkoside G
Catalog No.:BCN2272
CAS No.:160896-46-8
- Hosenkoside F
Catalog No.:BCN2520
CAS No.:160896-45-7
- Fmoc-Valinol
Catalog No.:BCC2694
CAS No.:160885-98-3
- Chrysin 8-C-glucoside
Catalog No.:BCN7982
CAS No.:160880-89-7
- Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
Catalog No.:BCC8967
CAS No.:160844-75-7
- H-Thr(Bzl)-ol
Catalog No.:BCC2577
CAS No.:160841-03-2
- AMG319
Catalog No.:BCC6510
CAS No.:1608125-21-8
- Indirubin-3'-oxime
Catalog No.:BCC7185
CAS No.:160807-49-8
- Ardisicrenoside B
Catalog No.:BCN8078
CAS No.:160791-12-8
- 2,3-Dihydro-3alpha-methoxynimbolide
Catalog No.:BCN7093
CAS No.:1607828-35-2
- Mps1-IN-3
Catalog No.:BCC5496
CAS No.:1609584-72-6
- 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl bromide
Catalog No.:BCN1547
CAS No.:160969-00-6
- 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate
Catalog No.:BCN1546
CAS No.:160969-03-9
- Silodosin
Catalog No.:BCN2164
CAS No.:160970-54-7
- TH287
Catalog No.:BCC6400
CAS No.:1609960-30-6
- TH588
Catalog No.:BCC6397
CAS No.:1609960-31-7
- Dihydroperaksine
Catalog No.:BCN1713
CAS No.:16100-84-8
- Hosenkoside M
Catalog No.:BCN4518
CAS No.:161016-51-9
- VT-464
Catalog No.:BCC5398
CAS No.:1610537-15-9
- Epimedokoreanin B
Catalog No.:BCN6483
CAS No.:161068-53-7
- Epimedokoreanin C
Catalog No.:BCN8080
CAS No.:161068-54-8
- Formyl-DL-Trp-OH
Catalog No.:BCC3120
CAS No.:16108-03-5