Home >> Research Area >> AZD3264

AZD3264

IKK2 inhibitor CAS# 1609281-86-8

AZD3264

Catalog No. BCC6514----Order now to get a substantial discount!

Product Name & Size Price Stock
AZD3264: 5mg $161 In Stock
AZD3264: 10mg Please Inquire In Stock
AZD3264: 20mg Please Inquire Please Inquire
AZD3264: 50mg Please Inquire Please Inquire
AZD3264: 100mg Please Inquire Please Inquire
AZD3264: 200mg Please Inquire Please Inquire
AZD3264: 500mg Please Inquire Please Inquire
AZD3264: 1000mg Please Inquire Please Inquire
Related Products
  • MK-4827

    Catalog No.:BCC1761
    CAS No.:1038915-60-4
  • BMN-673 8R,9S

    Catalog No.:BCC1422
    CAS No.:1207456-00-5
  • XAV-939

    Catalog No.:BCC1120
    CAS No.:284028-89-3
  • PJ34

    Catalog No.:BCC1865
    CAS No.:344458-19-1
  • ABT-888 (Veliparib)

    Catalog No.:BCC1267
    CAS No.:912444-00-9

Quality Control of AZD3264

Number of papers citing our products

Chemical structure

AZD3264

3D structure

Chemical Properties of AZD3264

Cas No. 1609281-86-8 SDF Download SDF
PubChem ID 91666658 Appearance Powder
Formula C21H23N5O4S M.Wt 441.5
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : ≥ 48 mg/mL (108.72 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name 2-(carbamoylamino)-5-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(3S)-pyrrolidin-3-yl]oxyphenyl]thiophene-3-carboxamide
SMILES CC1=C(C(=NO1)C)C2=CC(=C(C=C2)C3=CC(=C(S3)NC(=O)N)C(=O)N)OC4CCNC4
Standard InChIKey NMFIXEFNQPDISY-ZDUSSCGKSA-N
Standard InChI InChI=1S/C21H23N5O4S/c1-10-18(11(2)30-26-10)12-3-4-14(16(7-12)29-13-5-6-24-9-13)17-8-15(19(22)27)20(31-17)25-21(23)28/h3-4,7-8,13,24H,5-6,9H2,1-2H3,(H2,22,27)(H3,23,25,28)/t13-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of AZD3264

DescriptionAZD3264 is a selective IkB-kinase IKK2 inhibitor.In Vivo:AZD3264 is a selective IkB-kinase IKK2 inhibitor, which is currently in preclinical development for the potential treatment of chronic pulmonary obstructive disorder (COPD) and asthma[1].

References:
[1]. Andiappan Murugan, et al. Exploiting the Differential Reactivities of Halogen Atoms: Development of a Scalable Route to IKK2 Inhibitor AZD3264. Org Process Res Dev. 2014 Apr 29;18(5): 646-651.

AZD3264 Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

AZD3264 Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of AZD3264

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.265 mL 11.325 mL 22.6501 mL 45.3001 mL 56.6251 mL
5 mM 0.453 mL 2.265 mL 4.53 mL 9.06 mL 11.325 mL
10 mM 0.2265 mL 1.1325 mL 2.265 mL 4.53 mL 5.6625 mL
50 mM 0.0453 mL 0.2265 mL 0.453 mL 0.906 mL 1.1325 mL
100 mM 0.0227 mL 0.1133 mL 0.2265 mL 0.453 mL 0.5663 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on AZD3264

Target: IKK2

IC50: N/A

AZD3264 is a novel and small molecule IKK2 inhibitor.

IKK2 serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity induces the activation of a transcription factor NF-κB. Activated IKK2 phosphorylates IκB (IκBα), which binds NF-κB to inhibit its function. Phosphorylated IκB is degraded by the ubiquitination pathway, freeing NF-κB, and allowing its entry into the cell nucleus where it activates target genes involved in inflammation and other immune responses. Suppression of IKK2 has been identified as a potential therapeutic option to treat cancer and inflammatory diseases, including asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis [1].

In vitro: AZD3264, by inhibiting IKK2, was currently in preclinical development for the potential treatment of inflammatory diseases such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis [2].

In vivo: N/A

References:
1.  Llona-Minguez S, Baiget J, Mackay SP. Small-molecule inhibitors of IkappaB kinase (IKK) and IKK-related kinases. Pharm Pat Anal. 2013;2(4):481-98.
2.  Murugan A, et al. Org. Process Res. Dev. 2014, 18, 646-651.

Featured Products
New Products
 

Description

AZD3264 is a selective IkB-kinase IKK2 inhibitor.

Keywords:

AZD3264,1609281-86-8,Natural Products, buy AZD3264 , AZD3264 supplier , purchase AZD3264 , AZD3264 cost , AZD3264 manufacturer , order AZD3264 , high purity AZD3264

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: