2-Amino-3-hydroxyanthraquinoneCAS# 117-77-1 |
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| Cas No. | 117-77-1 | SDF | Download SDF |
| PubChem ID | 67029 | Appearance | Powder |
| Formula | C14H9NO3 | M.Wt | 239 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 2-amino-3-hydroxyanthracene-9,10-dione | ||
| SMILES | C1=CC=C2C(=C1)C(=O)C3=CC(=C(C=C3C2=O)O)N | ||
| Standard InChIKey | CNWWMJSRHGXXAX-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C14H9NO3/c15-11-5-9-10(6-12(11)16)14(18)8-4-2-1-3-7(8)13(9)17/h1-6,16H,15H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
2-Amino-3-hydroxyanthraquinone Dilution Calculator
2-Amino-3-hydroxyanthraquinone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.1841 mL | 20.9205 mL | 41.841 mL | 83.682 mL | 104.6025 mL |
| 5 mM | 0.8368 mL | 4.1841 mL | 8.3682 mL | 16.7364 mL | 20.9205 mL |
| 10 mM | 0.4184 mL | 2.0921 mL | 4.1841 mL | 8.3682 mL | 10.4603 mL |
| 50 mM | 0.0837 mL | 0.4184 mL | 0.8368 mL | 1.6736 mL | 2.0921 mL |
| 100 mM | 0.0418 mL | 0.2092 mL | 0.4184 mL | 0.8368 mL | 1.046 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Microbial Synthesis of Non-Natural Anthraquinone Glucosides Displaying Superior Antiproliferative Properties.[Pubmed:30154376]
Molecules. 2018 Aug 28;23(9). pii: molecules23092171.
Anthraquinones, naturally occurring bioactive compounds, have been reported to exhibit various biological activities, including anti-inflammatory, antiviral, antimicrobial, and anticancer effects. In this study, we biotransformed three selected anthraquinones into their novel O-glucoside derivatives, expressing a versatile glycosyltransferase (YjiC) from Bacillus licheniformis DSM 13 in Escherichia coli. Anthraflavic acid, alizarin, and 2-Amino-3-hydroxyanthraquinone were exogenously fed to recombinant E. coli as substrate for biotransformation. The products anthraflavic acid-O-glucoside, alizarin 2-O-beta-d-glucoside, and 2-amino-3-O-glucosyl anthraquinone produced in the culture broths were characterized by various chromatographic and spectroscopic analyses. The comparative anti-proliferative assay against various cancer cells (gastric cancer-AGS, uterine cervical cancer-HeLa, and liver cancer-HepG2) were remarkable, since the synthesized glucoside compounds showed more than 60% of cell growth inhibition at concentrations ranging from ~50 muM to 100 muM. Importantly, one of the synthesized glucoside derivatives, alizarin 2-O-glucoside inhibited more than 90% of cell growth in all the cancer cell lines tested.
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