2-Anthraquinonecarboxylic acidCAS# 117-78-2 |
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| Cas No. | 117-78-2 | SDF | Download SDF |
| PubChem ID | 67030 | Appearance | Yellow powder |
| Formula | C15H8O4 | M.Wt | 252.2 |
| Type of Compound | Anthraquinones | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 9,10-dioxoanthracene-2-carboxylic acid | ||
| SMILES | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C=C(C=C3)C(=O)O | ||
| Standard InChIKey | ASDLSKCKYGVMAI-UHFFFAOYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Anthraquinone-2-carboxylic acid is a novel electron shuttling mediator, shows potent anti-inflammatory and antinociceptive activities in vivo, thus contributing to the immune regulatory role of fruits and herbs. |
| Targets | AP-1 | NF-kB | Src | Syk | p38MAPK |
| In vivo | Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid[Pubmed: 27057092]Mediators Inflamm. 2016; 2016: 1903849.Anthraquinone compounds are one of the abundant polyphenols found in fruits, vegetables, and herbs. However, the in vivo anti-inflammatory activity and molecular mechanisms of anthraquinones have not been fully elucidated. |
| Structure Identification | Journal of Materials Chemistry.2011 Aug;21(39):15383-15390.Photo-induced self-cleaning functions on 2-anthraquinone carboxylic acid treated cotton fabrics.[Reference: WebLink]
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2-Anthraquinonecarboxylic acid Dilution Calculator
2-Anthraquinonecarboxylic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.9651 mL | 19.8255 mL | 39.6511 mL | 79.3021 mL | 99.1277 mL |
| 5 mM | 0.793 mL | 3.9651 mL | 7.9302 mL | 15.8604 mL | 19.8255 mL |
| 10 mM | 0.3965 mL | 1.9826 mL | 3.9651 mL | 7.9302 mL | 9.9128 mL |
| 50 mM | 0.0793 mL | 0.3965 mL | 0.793 mL | 1.586 mL | 1.9826 mL |
| 100 mM | 0.0397 mL | 0.1983 mL | 0.3965 mL | 0.793 mL | 0.9913 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid.[Pubmed:27057092]
Mediators Inflamm. 2016;2016:1903849.
Anthraquinone compounds are one of the abundant polyphenols found in fruits, vegetables, and herbs. However, the in vivo anti-inflammatory activity and molecular mechanisms of anthraquinones have not been fully elucidated. We investigated the activity of anthraquinones using acute inflammatory and nociceptive experimental conditions. Anthraquinone-2-carboxylic acid (9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid, AQCA), one of the major anthraquinones identified from Brazilian taheebo, ameliorated various inflammatory and algesic symptoms in EtOH/HCl- and acetylsalicylic acid- (ASA-) induced gastritis, arachidonic acid-induced edema, and acetic acid-induced abdominal writhing without displaying toxic profiles in body and organ weight, gastric irritation, or serum parameters. In addition, AQCA suppressed the expression of inflammatory genes such as cyclooxygenase- (COX-) 2 in stomach tissues and lipopolysaccharide- (LPS-) treated RAW264.7 cells. According to reporter gene assay and immunoblotting analyses, AQCA inhibited activation of the nuclear factor- (NF-) kappaB and activator protein- (AP-) 1 pathways by suppression of upstream signaling involving interleukin-1 receptor-associated kinase 4 (IRAK1), p38, Src, and spleen tyrosine kinase (Syk). Our data strongly suggest that anthraquinones such as AQCA act as potent anti-inflammatory and antinociceptive components in vivo, thus contributing to the immune regulatory role of fruits and herbs.
