Dantron

CAS# 117-10-2

Dantron

Catalog No. BCN6048----Order now to get a substantial discount!

Product Name & Size Price Stock
Dantron: 5mg Please Inquire In Stock
Dantron: 10mg Please Inquire In Stock
Dantron: 20mg Please Inquire Please Inquire
Dantron: 50mg Please Inquire Please Inquire
Dantron: 100mg Please Inquire Please Inquire
Dantron: 200mg Please Inquire Please Inquire
Dantron: 500mg Please Inquire Please Inquire
Dantron: 1000mg Please Inquire Please Inquire

Quality Control of Dantron

Number of papers citing our products

Chemical structure

Dantron

3D structure

Chemical Properties of Dantron

Cas No. 117-10-2 SDF Download SDF
PubChem ID 2950 Appearance Orange-brown powder
Formula C14H8O4 M.Wt 240.2
Type of Compound Anthraquinones Storage Desiccate at -20°C
Synonyms Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone
Solubility DMSO : ≥ 42 mg/mL (174.85 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name 1,8-dihydroxyanthracene-9,10-dione
SMILES C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=CC=C3O
Standard InChIKey QBPFLULOKWLNNW-UHFFFAOYSA-N
Standard InChI InChI=1S/C14H8O4/c15-9-5-1-3-7-11(9)14(18)12-8(13(7)17)4-2-6-10(12)16/h1-6,15-16H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Dantron

The roots of Rheum palmatum

Biological Activity of Dantron

DescriptionDanthron is an organic substance. It used to be a laxatica and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.Dantron can cause a significant reduction in the growth rate of Earthworms, it has potentially dangerous to the soil ecosystem.
TargetsAMPK | Antifection
In vivo

Factors influencing constipation in advanced cancer patients: a prospective study of opioid dose, dantron dose and physical functioning.[Pubmed: 12882260]

Palliat Med. 2003 Jul;17(5):418-22.


METHODS AND RESULTS:
The relationship between opioid dose, Dantron dose, bowel function and physical functioning (measured with the modified Barthel Index) was determined in a sample of 50 inpatients with advanced cancer. Data were collected prospectively from chart review and patient interviews one week after admission to allow for protocol-driven management of constipation to be established. Bowel scores were significantly reduced in 35 patients treated with opioids compared with 15 patients not treated with opioids. Within the opioid group, however, there was no relationship between opioid dose, bowel score, Dantron dose or Barthel Index. Higher doses of Dantron were associated with better physical functioning (but not opioid dose) suggesting that for any given dose of opioid, fitter patients were treated with larger doses of laxatives.
CONCLUSIONS:
Factors other than opioid dose and physical functioning may be more important in contributing to constipation in this group of patients. Less potent opioid drugs, such as codeine, are just as likely to cause constipation as more potent opioids.

Cleansing of the colon without enemas.[Pubmed: 1215526]

Radiologe. 1975 Nov;15(11):421-6.

Several methods have been used to cleanse the large bowel prior to roentgen examination and rectoscopy for more than ten years.
METHODS AND RESULTS:
A method with administration of a salt solution (SALAX) in combination with different oral laxatives (Cascara sagrada, Dantron, Bisacodyl) without cleansing enemas is described. Hospitalized patients should have an individual preparation while ambulatory patients are almost completely cleansed if they carefully follow the given instructions.

Adverse effects of drugs used in the management of constipation and diarrhoea.[Pubmed: 8136086]

Drug Saf. 1994 Jan;10(1):47-65.

Most laxatives, if used intermittently in the absence of contraindications, are relatively safe. Bulking agents may diminish absorption of some minerals and drugs, but this is not usually clinically significant. Ispaghula can cause serious allergic reactions. The chronic ingestion of stimulant laxatives has been blamed for the development of the 'cathartic colon', but there are no definitive studies which have demonstrated this.
METHODS AND RESULTS:
Dantron (danthron) preparations should only be used in older patients and the terminally ill because of the risk of hepatotoxicity with this drug. Oral oxyphenisatine should no longer be used. Senna would appear to be the stimulant laxative of choice during pregnancy and lactation. Bisacodyl is the polyphenolic derivative of choice. Lactulose, sorbitol and lactilol rarely cause significant adverse effects. Magnesium salt laxatives and phosphate enemas can cause serious metabolic disturbances in babies and young children. Liquid paraffin is contraindicated if there is any risk of aspiration. Interference with the absorption of fat soluble vitamins would not appear to be clinically significant. Docusate sodium may potentiate the hepatotoxicity of other drugs, but reports of this are rare. The role of cisapride in constipation has not been established. Antidiarrhoeal drugs are second line drugs whose use is aimed at minimising inconvenience and discomfort. No antidiarrhoeals can be recommended for children under 4 years of age. Loperamide is the drug of choice in older children and adults. The atropine component of diphenoxylate/atropine combinations can cause significant adverse effects. Bismuth salicylate is an inconvenient treatment for travellers' diarrhoea as large frequent doses of the liquid formulation are needed. Some bismuth can be absorbed and there is the potential to cause encephalopathy. Octreotide, methysergide and cholestyramine have a role for specific causes of diarrhoea only.
CONCLUSIONS:
Octreotide is effective in high output states from the small or large bowel, with few adverse effects. Clonidine and lidamidine may have a role in the treatment of chronic diabetic diarrhoea. The role of lidamidine in nondiabetic chronic diarrhoea has not been established.

Protocol of Dantron

Animal Research

Effect of 1,8-dihydroxyanthraquinone on body mass and protein content of earthworms[Reference: WebLink]

Chinese Journal of Clinical Rehabilitation, 2005, 9(15):225-7.


METHODS AND RESULTS:
Effects of 1, 8-dihydroxyanthraquinone(Dantron) on growth rate and protein content of earthworms. No lethal effect of 1, 8-dihydroxyanthraquinone(Dantron) was observed even at the highest concentration(1.0 g/kg soil) of exposure. The sub-lethal effect, however, was evident at all the concentration scale. 1, 8-dihydroxyanthraquinone(Dantron) caused a significant reduction in the growth rate (maximum - 22.5%) at the dosage of 1.0 g/kg and 28 days contact time. Additionally a reduction in total soluble protein was observed in all treated worms(maximum - 39.6%) at the dosage of 0.8 g/kg and 7 days contact time.
CONCLUSIONS:
1, 8-dihydroxyanthraquinone (Dantron) was potentially dangerous to the soil ecosystem and more ecological risk assessment of this chemical material should be thoroughly carried out.

Dantron Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Dantron Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Dantron

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1632 mL 20.816 mL 41.632 mL 83.2639 mL 104.0799 mL
5 mM 0.8326 mL 4.1632 mL 8.3264 mL 16.6528 mL 20.816 mL
10 mM 0.4163 mL 2.0816 mL 4.1632 mL 8.3264 mL 10.408 mL
50 mM 0.0833 mL 0.4163 mL 0.8326 mL 1.6653 mL 2.0816 mL
100 mM 0.0416 mL 0.2082 mL 0.4163 mL 0.8326 mL 1.0408 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Dantron

Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.

In Vitro:Danthron (0.1, 1, and 10 μM) dose-dependently promotes the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in both HepG2 and C2C12 cells. Meanwhile, Danthron treatment significantly reduces the lipid synthesis related sterol regulatory element-binding protein 1c (SREBP1c) and fatty acid synthetase (FAS) gene expressions, and the total cholesterol (TC) and triglyceride (TG) levels. In addition, Danthron treatment efficiently increases glucose consumption. Danthron effectively reduces intracellular lipid contents and enhances glucose consumption in vitro via activation of AMPK signaling pathway. 10 μM Danthron/24 h is safe for HepG2 cells. With 80% confluence, HepG2 cells are incubated with Danthron (0.1-10 μM) in FBS-Free media for 8 h. Subsequently, cells are harvested for Western blot assay. Danthron increases the p-AMPK protein in a dose-dependent manner, and no changes in t-AMPK protein are observed[1]. Danthron inhibits 9-cis retinoic acid (9cRA)-induced retinoic X receptor α (RXRα) transactivation by IC50 at 0.11 μM. To further clarify the stoichimetric ratio of Danthron binding to RXRα-ligand-binding domain (LBD), isothermal titration calorimetry (ITC) experiment is performed. The KD value of Danthron binds to RXRα-LBD by ITC experiment is determined at 7.5 μM[2].

In Vivo:Danthron functions as an insulin sensitizer in vivo. Danthron improves insulin sensitivity in diet-induced obese (DIO) mice. The insulin tolerance test result shows that Danthron (5 mg/kg) treated diet-induced obesity mice exhibit lower glucose levels after insulin challenge, compared with the control vehicle-treated group[2].

References:
[1]. Zhou R, et al. Danthron activates AMP-activated protein kinase and regulates lipid and glucose metabolism in vitro. Acta Pharmacol Sin. 2013 Aug;34(8):1061-9. [2]. Zhang H, et al. Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. J Biol Chem. 2011 Jan 21;286(3):1868-75.

Featured Products
New Products
 

References on Dantron

Factors influencing constipation in advanced cancer patients: a prospective study of opioid dose, dantron dose and physical functioning.[Pubmed:12882260]

Palliat Med. 2003 Jul;17(5):418-22.

The relationship between opioid dose, Dantron dose, bowel function and physical functioning (measured with the modified Barthel Index) was determined in a sample of 50 inpatients with advanced cancer. Data were collected prospectively from chart review and patient interviews one week after admission to allow for protocol-driven management of constipation to be established. Bowel scores were significantly reduced in 35 patients treated with opioids compared with 15 patients not treated with opioids. Within the opioid group, however, there was no relationship between opioid dose, bowel score, Dantron dose or Barthel Index. Higher doses of Dantron were associated with better physical functioning (but not opioid dose) suggesting that for any given dose of opioid, fitter patients were treated with larger doses of laxatives. Factors other than opioid dose and physical functioning may be more important in contributing to constipation in this group of patients. Less potent opioid drugs, such as codeine, are just as likely to cause constipation as more potent opioids.

Adverse effects of drugs used in the management of constipation and diarrhoea.[Pubmed:8136086]

Drug Saf. 1994 Jan;10(1):47-65.

Most laxatives, if used intermittently in the absence of contraindications, are relatively safe. Bulking agents may diminish absorption of some minerals and drugs, but this is not usually clinically significant. Ispaghula can cause serious allergic reactions. The chronic ingestion of stimulant laxatives has been blamed for the development of the 'cathartic colon', but there are no definitive studies which have demonstrated this. Dantron (danthron) preparations should only be used in older patients and the terminally ill because of the risk of hepatotoxicity with this drug. Oral oxyphenisatine should no longer be used. Senna would appear to be the stimulant laxative of choice during pregnancy and lactation. Bisacodyl is the polyphenolic derivative of choice. Lactulose, sorbitol and lactilol rarely cause significant adverse effects. Magnesium salt laxatives and phosphate enemas can cause serious metabolic disturbances in babies and young children. Liquid paraffin is contraindicated if there is any risk of aspiration. Interference with the absorption of fat soluble vitamins would not appear to be clinically significant. Docusate sodium may potentiate the hepatotoxicity of other drugs, but reports of this are rare. The role of cisapride in constipation has not been established. Antidiarrhoeal drugs are second line drugs whose use is aimed at minimising inconvenience and discomfort. No antidiarrhoeals can be recommended for children under 4 years of age. Loperamide is the drug of choice in older children and adults. The atropine component of diphenoxylate/atropine combinations can cause significant adverse effects. Bismuth salicylate is an inconvenient treatment for travellers' diarrhoea as large frequent doses of the liquid formulation are needed. Some bismuth can be absorbed and there is the potential to cause encephalopathy. Octreotide, methysergide and cholestyramine have a role for specific causes of diarrhoea only. Octreotide is effective in high output states from the small or large bowel, with few adverse effects. Clonidine and lidamidine may have a role in the treatment of chronic diabetic diarrhoea. The role of lidamidine in nondiabetic chronic diarrhoea has not been established.

Cleansing of the colon without enemas.[Pubmed:1215526]

Radiologe. 1975 Nov;15(11):421-6.

Several methods have been used to cleanse the large bowel prior to roentgen examination and rectoscopy for more than ten years. A method with administration of a salt solution (SALAX) in combination with different oral laxatives (Cascara sagrada, Dantron, Bisacodyl) without cleansing enemas is described. Hospitalized patients should have an individual preparation while ambulatory patients are almost completely cleansed if they carefully follow the given instructions.

Description

Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.

Keywords:

Dantron,117-10-2,Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone,Natural Products, buy Dantron , Dantron supplier , purchase Dantron , Dantron cost , Dantron manufacturer , order Dantron , high purity Dantron

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: