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3-Prenyl-2,4,6-trihydroxybenzophenone

CAS# 93796-20-4

3-Prenyl-2,4,6-trihydroxybenzophenone

Catalog No. BCN1303----Order now to get a substantial discount!

Product Name & Size Price Stock
3-Prenyl-2,4,6-trihydroxybenzophenone: 5mg $748 In Stock
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Quality Control of 3-Prenyl-2,4,6-trihydroxybenzophenone

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Chemical structure

3-Prenyl-2,4,6-trihydroxybenzophenone

3D structure

Chemical Properties of 3-Prenyl-2,4,6-trihydroxybenzophenone

Cas No. 93796-20-4 SDF Download SDF
PubChem ID 14282624 Appearance Yellow powder
Formula C18H18O4 M.Wt 298.3
Type of Compound Xanthones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name phenyl-[2,4,6-trihydroxy-3-(3-methylbut-2-enyl)phenyl]methanone
SMILES CC(=CCC1=C(C=C(C(=C1O)C(=O)C2=CC=CC=C2)O)O)C
Standard InChIKey WKFZVPVRFGJMEY-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3-Prenyl-2,4,6-trihydroxybenzophenone

The herbs of Garcinia cowa

Protocol of 3-Prenyl-2,4,6-trihydroxybenzophenone

Structure Identification
Synthetic Communications, 2017, 47(6):599-603.

Synthesis of 3-geranyl- and 3-prenyl-2,4,6-trihydroxybenzophenone.[Reference: WebLink]


METHODS AND RESULTS:
Biologically active phenyl[3-(3,7-dimethyl-2,6-octadienyl)-2,4,6-trihydroxyphenyl]methanone (2) and phenyl[2,4,6-trihydroxy-3-(3-methyl-2-butenyl)phenyl]methanone (3) were synthesized by an efficient and convenient synthetic sequence.
CONCLUSIONS:
The reaction steps of this synthesis included methylation, Friedel-Crafts acylation, demethylation and geranylation steps.

3-Prenyl-2,4,6-trihydroxybenzophenone Dilution Calculator

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3-Prenyl-2,4,6-trihydroxybenzophenone Molarity Calculator

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Preparing Stock Solutions of 3-Prenyl-2,4,6-trihydroxybenzophenone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3523 mL 16.7616 mL 33.5233 mL 67.0466 mL 83.8082 mL
5 mM 0.6705 mL 3.3523 mL 6.7047 mL 13.4093 mL 16.7616 mL
10 mM 0.3352 mL 1.6762 mL 3.3523 mL 6.7047 mL 8.3808 mL
50 mM 0.067 mL 0.3352 mL 0.6705 mL 1.3409 mL 1.6762 mL
100 mM 0.0335 mL 0.1676 mL 0.3352 mL 0.6705 mL 0.8381 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3-Prenyl-2,4,6-trihydroxybenzophenone

Induction of apoptosis of 2,4',6-trihydroxybenzophenone in HT-29 colon carcinoma cell line.[Pubmed:24579081]

Biomed Res Int. 2014;2014:468157.

2,4',6-Trihydroxy-4-methoxybenzophenone was isolated from the ethyl acetate fraction of Phaleria macrocarpa (Scheff.) Boerl. fruits. It was found to inhibit cell proliferation in HT-29 human colon carcinoma cell line but caused little damage to WRL-68 normal human liver and MRC-5 normal human fibroblast lung cell lines. The compound was found to sharply affect the viability of HT-29 cells in a dose- and time-dependent manner. HT-29 cells treated with the compound showed morphological changes under microscopic examination such as cell shrinkage, membrane blebbing, DNA fragmentation, and the occurrence of apoptotic nuclei. The percentage of early apoptotic, late apoptotic, and dead or necrotic cells was determined by flow cytometry using annexin V-FTIC/PI staining. In addition, flow cytometry showed that, when the HT-29 cells were treated with 115 microM of the compound, it resulted in G0/G1 phase arrest in a time-dependent manner. Western blot revealed an upregulation of PUMA, Bak, Bcl-2, and Mcl-1 proteins suggesting that the compound induced apoptosis in HT-29 cells by regulating these proteins.

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