Roxatidine Acetate HClCAS# 93793-83-0 |
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Quality Control & MSDS
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| Cas No. | 93793-83-0 | SDF | Download SDF |
| PubChem ID | 56704 | Appearance | Powder |
| Formula | C19H29ClN2O4 | M.Wt | 384.9 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 50 mg/mL (129.90 mM; Need ultrasonic) H2O : ≥ 50 mg/mL (129.90 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | [2-oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] acetate;hydrochloride | ||
| SMILES | [H+].[Cl-].CC(=O)OCC(=O)NCCCOc1cccc(CN2CCCCC2)c1 | ||
| Standard InChIKey | FEWCTJHCXOHWNL-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C19H28N2O4.ClH/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21;/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23);1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Roxatidine Acetate HCl Dilution Calculator
Roxatidine Acetate HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5981 mL | 12.9904 mL | 25.9808 mL | 51.9615 mL | 64.9519 mL |
| 5 mM | 0.5196 mL | 2.5981 mL | 5.1962 mL | 10.3923 mL | 12.9904 mL |
| 10 mM | 0.2598 mL | 1.299 mL | 2.5981 mL | 5.1962 mL | 6.4952 mL |
| 50 mM | 0.052 mL | 0.2598 mL | 0.5196 mL | 1.0392 mL | 1.299 mL |
| 100 mM | 0.026 mL | 0.1299 mL | 0.2598 mL | 0.5196 mL | 0.6495 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Roxatidine Acetate HCl is a specific and competitive histamin H2 receptor antagonist.
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Cytoprotective action of roxatidine acetate HCl.[Pubmed:2906796]
Arch Int Pharmacodyn Ther. 1988 Jul-Aug;294:295-304.
The cytoprotective action of Roxatidine Acetate HCl (roxatidine) was investigated. We also studied the involvement of endogenous prostaglandins (PGs) in the cytoprotective action of roxatidine and the effect of roxatidine on SRS content in pleurisy induced by A23187. Simultaneously, these effects of roxatidine were compared with those of other histamine H2-receptor antagonists at the same anti-secretory activity level. Roxatidine prevented formation of the gastric mucosal lesions induced by abs. ethanol, 0.6 N HCl and 0.2 N NaOH, but it failed to prevent 30% NaCl-induced gastric mucosal lesions. Cimetidine, ranitidine and famotidine failed to prevent formation of the gastric mucosal lesions induced by necrotizing agents. The cytoprotective action of roxatidine was not abolished by pretreatment with indomethacin. Roxatidine did not greatly influence SRS production. Consequently, it appears that roxatidine has a cytoprotective action and that this action is not associated with endogenous PGs and SRS.
Roxatidine Acetate Hydrochloride is a specific and competitive histamin H2 receptor antagonist.
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