Histamine Receptor - Neuroscience

Cat.No. Product Name Information

BCC4532 Pemirolast potassium Pemirolast potassium (TWT-8152) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

BCC4540 Desloratadine Desloratadine(Sch34117) is a potent antagonist for human histamine H1 receptor used to treat allergies.

BCC6285 VUF 10460 VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46.

BCC6922 Zolantidine dimaleate

BCC7963 A 331440 dihydrochloride Selective H3 antagonist

BCC4132 Mizolastine dihydrochloride Mizolastine dihydrochloride is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.

BCC6734 Thioperamide

BCC7732 A 987306 Potent and selective H4 receptor antagonist

BCC4521 Mizolastine Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.

BCC1404 Bavisant dihydrochloride hydrate Bavisant dihydrochloride hydrate (JNJ31001074AAC) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.

BCC4526 Chlorpheniramine Maleate Chlorpheniramine maleate is an histamine H1 receptor antagonist with IC50 of 12 nM.

BCC4544 Lafutidine Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.

BCC5669 DPPE fumarate

BCC7772 A 943931 dihydrochloride Potent and selective H4 antagonist

BCC4516 Buclizine HCl Buclizine HCl is an antihistamine and anticholinergic of the piperazine derivative family.

BCC5549 Decloxizine dihydrochloride Decloxizine dihydrochloride(UCB-1402; NSC289116) is a histamine 1 receptor antagonist.

BCC4524 Benztropine mesylate Benzatropine mesylate is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease.

BCC1084 Lidocaine Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative commonly used to anesthetize. Lidocaine is a drug to treat ventricular arrhythmia and an effective tumor-inhibitor.

BCC4545 Olopatadine HCl Olopatadine hydrochloride (ALO4943A) is a histamine blocker used to treat allergic conjunctivitis.

BCC6761 Aminopotentidine

BCC6744 Amthamine dihydrobromide

BCC6793 Iodophenpropit dihydrobromide Iodophenpropit dihydrobromide is a potent and selective histamine H3 receptor antagonist. The binding of [125I]Iodophenpropit is selective, saturable, readily reversible, and of high affinity (KD 0.32 nM).

BCC6781 Clobenpropit dihydrobromide Clobenpropit dihydrobromide is a potent histamine H3R antagonist/inverse agonist with a pEC50 of 8.07 for histamine H3LR. Clobenpropit dihydrobromide acts as partial agonist at histamine H4 receptors (Ki 13 nM). Clobenpropit dihydrobromide also binds to serotonin 5-HT3 receptors (Ki 7.4 nM) and α2A/α2C adrenoceptors (Ki 17.4/7.8 nM). Clobenpropit dihydrobromide increases apoptosis.

BCC5260 Alcaftadine Alcaftadine(R89674) is a H1 histamine receptor antagonist, which is used to prevent eye irritation brought on by allergic conjunctivitis.

BCC7197 Impentamine dihydrobromide

BCC4528 Clemastine Fumarate Clemastine (fumarate) (HS-592 (fumarate)) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.

BCC7357 GT 2016 GT 2016

BCC4542 Fexofenadine HCl Fexofenadine hydrochloride (MDL-16455 hydrochloride), a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial (person aged ≥16 years).

BCC4523 Tripelennamine HCl Tripelennamine hydrochloride, a H1-receptor antagonist, is a psychoactive drug and member of the pyridine andethylenediamine classes that is used as an antipruritic and first-generation antihistamine.

BCC6853 Immepip dihydrobromide

BCC6701 Nα-Methylhistamine dihydrochloride

BCC7378 Proxyfan oxalate

BCC4535 Rupatadine Fumarate Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).

BCC4539 Ciproxifan Ciproxifan(FUB-359) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.

BCC4049 Ciproxifan maleate Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.

BCC7245 ROS 234 dioxalate

BCC4538 Bepotastine Besilate Bepotastine Beslilate is a orally active second-generation histamine H1 receptor antagonist. Bepotastine Beslilate has the potential for allergic rhinitis and urticaria/pruritus treatment.

BCC6736 HTMT dimaleate

BCC5263 Bilastine Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria.

BCC1114 Mianserin HCl Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.

BCC4519 Hydroxyzine 2HCl Hydroxyzine dihydrochloride is a histamine H1-receptor antagonist.

BCC6672 Dimaprit dihydrochloride

BCC4134 Mianserin Mianserin is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.

BCC6768 Imetit dihydrobromide Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM).

BCC7379 2-Pyridylethylamine dihydrochloride

BCC4531 Ketotifen Fumarate Ketotifen (fumarate) is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks.

BCC1862 Pitolisant Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).

BCC1864 Pitolisant oxalate Pitolisant oxalate is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).

BCC7337 4-Methylhistamine dihydrochloride Selective, high affinity H4 agonist

BCC5529 Decloxizine Decloxizine(UCB-1402; NSC289116) is a histamine 1 receptor antagonist.

BCC4133 Azatadine Azatadine is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.

BCC4536 Azatadine dimaleate Azatadine dimaleate is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.

BCC6101 JNJ 5207852 dihydrochloride JNJ-5207852 is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.

BCC1485 Clemizole Clemizole is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 µM.

BCC4543 JNJ-7777120 JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.

BCC4527 Cimetidine Cimetidine is a histamine-2 (H2) receptor antagonist.

BCC7842 JNJ 10181457 dihydrochloride

BCC7352 Conessine

BCC6742 trans-Triprolidine hydrochloride

BCC4525 Betahistine 2HCl Betahistine dihydrochloride is a potent, orally active histamine H1 receptor agonist and H3 receptor antagonist. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA).

BCC4530 Histamine 2HCl Histamine dihydrochloride is an endogenous metabolite.

BCC7291 Carcinine ditrifluoroacetate

BCC4518 Cyclizine 2HCl Cyclizine 2HCl is a piperazine derivative with Histamine H1 receptor antagonist activity.

BCC6740 Mepyramine maleate Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pKd of 9.4 for H1 receptor.

BCC7383 VUF 5681 dihydrobromide

BCC4533 Ranitidine Hydrochloride Ranitidine hydrochloride is a histamine H2-receptor antagonist that inhibits stomach acid production.

BCC5209 Hydroxyzine Hydroxyzine is a histamine H1-receptor antagonist.

BCC7691 Astemizole Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K+ channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects.

BCC5676 Tiotidine Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). Tiotidine has low affinity for both the H1 and the H3 receptors.

BCC7328 Immethridine dihydrobromide

BCC6700 (S)-(+)-α-Methylhistamine dihydrobromide

BCC4529 Famotidine Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

BCC4522 Nizatidine Nizatidine is a histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion.

BCC4537 Azelastine HCl Azelastine hydrochloride is a potent, second-generation, selective, histamine antagonist.

BCC1262 Loratadine Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity.

BCC7524 Methimepip dihydrobromide

BCC1469 Cetirizine Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

BCC4517 Cetirizine DiHCl Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3]. Cetirizine DiHCl

BCC6808 ICI 162,846

BCC5665 (R)-(-)-α-Methylhistamine dihydrobromide (R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective H3 histamine receptor agonist with a Kd of 50.3 nM. (R)-(-)-α-Methylhistamine dihydrobromide can cross the blood-brain barrier, and can enhance memory retention, attenuates memory impairment in rats.

BCC7362 JNJ 10191584 maleate

BCC1863 Pitolisant hydrochloride Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).

BCC1402 Bavisant Bavisant (JNJ-31001074) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.

BCC1403 Bavisant dihydrochloride Bavisant Hcl (JNJ-31001074) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.

BCC4534 Roxatidine Acetate HCl Roxatidine Acetate Hydrochloride is a specific and competitive histamin H2 receptor antagonist.

BCC5161 Cyproheptadine hydrochloride Cyproheptadine hydrochloride is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM.

BCC4515 Brompheniramine hydrogen maleate Brompheniramine maleate is a histamine H1 receptors antagonist.

BCC4520 Levodropropizine Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive drug.

Products for Histamine Receptor