Methimepip dihydrobromideExtremely selective H3 agonist CAS# 817636-54-7 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 817636-54-7 | SDF | Download SDF |
| PubChem ID | 11313836 | Appearance | Powder |
| Formula | C10H19Br2N3 | M.Wt | 341.09 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in water | ||
| Chemical Name | 4-(1H-imidazol-5-ylmethyl)-1-methylpiperidine;dihydrobromide | ||
| SMILES | CN1CCC(CC1)CC2=CN=CN2.Br.Br | ||
| Standard InChIKey | XTJPHXJFOFOXJG-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C10H17N3.2BrH/c1-13-4-2-9(3-5-13)6-10-7-11-8-12-10;;/h7-9H,2-6H2,1H3,(H,11,12);2*1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Extremely selective histamine H3 receptor agonist (pKi values are 9.0, 5.7, < 5.0 and < 5.0 for hH3, hH4, hH1 and hH2 receptors respectively). Potently inhibits EFS-evoked contractions of guinea pig ileum (pD2 = 8.26). |
Methimepip dihydrobromide Dilution Calculator
Methimepip dihydrobromide Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9318 mL | 14.6589 mL | 29.3178 mL | 58.6356 mL | 73.2944 mL |
| 5 mM | 0.5864 mL | 2.9318 mL | 5.8636 mL | 11.7271 mL | 14.6589 mL |
| 10 mM | 0.2932 mL | 1.4659 mL | 2.9318 mL | 5.8636 mL | 7.3294 mL |
| 50 mM | 0.0586 mL | 0.2932 mL | 0.5864 mL | 1.1727 mL | 1.4659 mL |
| 100 mM | 0.0293 mL | 0.1466 mL | 0.2932 mL | 0.5864 mL | 0.7329 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist.[Pubmed:15771452]
J Med Chem. 2005 Mar 24;48(6):2100-7.
In this study, we continue our efforts toward the development of potent and highly selective histamine H(3) receptor agonists. We introduced various alkyl or aryl alkyl groups on the piperidine nitrogen of the known H(3)/H(4) agonist immepip and its analogues (1-3a). We observed that N-methyl-substituted immepip (methimepip) exhibits high affinity and agonist activity at the human histamine H(3) receptor (pK(i) = 9.0 and pEC(50) = 9.5) with a 2000-fold selectivity at the human H(3) receptor over the human H(4) receptor and more than a 10000-fold selectivity over the human histamine H(1) and H(2) receptors. Methimepip was also very effective as an H(3) receptor agonist at the guinea pig ileum (pD(2) = 8.26). Moreover, in vivo microdialysis (in rat brain) showed that methimepip reduces the basal level of brain histamine to about 25% after a 5 mg/kg intraperitoneal administration.
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