Betahistine 2HCl

CAS# 5579-84-0

Betahistine 2HCl

Catalog No. BCC4525----Order now to get a substantial discount!

Product Name & Size Price Stock
Betahistine 2HCl: 5mg $12 In Stock
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Quality Control of Betahistine 2HCl

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Chemical structure

Betahistine 2HCl

3D structure

Chemical Properties of Betahistine 2HCl

Cas No. 5579-84-0 SDF Download SDF
PubChem ID 68643 Appearance Powder
Formula C8H14Cl2N2 M.Wt 209.12
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 38 mg/mL (181.71 mM) in DMSO
Chemical Name N-methyl-2-pyridin-2-ylethanamine;dihydrochloride
SMILES [H+].[H+].[Cl-].[Cl-].CNCCc1ccccn1
Standard InChIKey XVDFMHARQUBJRE-UHFFFAOYSA-N
Standard InChI InChI=1S/C8H12N2.2ClH/c1-9-7-5-8-4-2-3-6-10-8;;/h2-4,6,9H,5,7H2,1H3;2*1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Betahistine 2HCl Dilution Calculator

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Betahistine 2HCl Molarity Calculator

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Preparing Stock Solutions of Betahistine 2HCl

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.7819 mL 23.9097 mL 47.8194 mL 95.6389 mL 119.5486 mL
5 mM 0.9564 mL 4.7819 mL 9.5639 mL 19.1278 mL 23.9097 mL
10 mM 0.4782 mL 2.391 mL 4.7819 mL 9.5639 mL 11.9549 mL
50 mM 0.0956 mL 0.4782 mL 0.9564 mL 1.9128 mL 2.391 mL
100 mM 0.0478 mL 0.2391 mL 0.4782 mL 0.9564 mL 1.1955 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Betahistine 2HCl

Betahistine is a histamine H3 receptors inhibitor with IC50 of 1.9 μM.

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References on Betahistine 2HCl

Effectiveness of the combined hearing and masking devices on the severity and perception of tinnitus: a randomized, controlled, double-blind study.[Pubmed:23899886]

ORL J Otorhinolaryngol Relat Spec. 2013;75(4):211-20.

OBJECTIVE: The aim of this study was to evaluate the effect of combined hearing and tinnitus masking devices that are appropriately programmed for acoustic stimulations using wide-band noise over the specific frequency range of tinnitus. MATERIAL AND METHODS: A total of 21 patients were randomly divided into 2 groups. Group I (12 patients) was managed with betahistine dihydrochloride (2HCl) and fitted either with a combined hearing aid or a sound generator, and group II (9 patients) was treated with Betahistine 2HCl for 3 months. Audiological tests, pitch matching to determine the frequency of tinnitus, an assessment of tinnitus severity, and subjective scores (visual analog scale, VAS; Mini-Tinnitus Questionnaire) were used to assess the patients in both groups, and a loudness scale was also analyzed in group I. The results were evaluated in a double-blinded manner. RESULTS: Significant decreases in the severity of tinnitus, Mini-Tinnitus Questionnaire score and VAS were observed in both groups. No significant differences were obtained in pitch-matched frequency of tinnitus in the two groups. CONCLUSION: The findings obtained using either the combined devices or the masking devices with wide-band masking demonstrate that these devices are an effective tinnitus treatment alternative.

Description

Betahistine dihydrochloride is a potent, orally active histamine H1 receptor agonist and H3 receptor antagonist. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA).

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