Chlorpheniramine MaleateCAS# 113-92-8 |
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Quality Control & MSDS
3D structure
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| Cas No. | 113-92-8 | SDF | Download SDF |
| PubChem ID | 5281068 | Appearance | Powder |
| Formula | C20H23ClN2O4 | M.Wt | 390.86 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 100 mg/mL (255.85 mM) H2O : 33.33 mg/mL (85.27 mM; Need ultrasonic) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (Z)-but-2-enedioic acid;3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine | ||
| SMILES | C[NH+](C)CCC(c1ccc(Cl)cc1)c2ccccn2.OC(=O)C=C/C([O-])=O | ||
| Standard InChIKey | DBAKFASWICGISY-BTJKTKAUSA-N | ||
| Standard InChI | InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1- | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Chlorpheniramine Maleate Dilution Calculator
Chlorpheniramine Maleate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5585 mL | 12.7923 mL | 25.5846 mL | 51.1692 mL | 63.9615 mL |
| 5 mM | 0.5117 mL | 2.5585 mL | 5.1169 mL | 10.2338 mL | 12.7923 mL |
| 10 mM | 0.2558 mL | 1.2792 mL | 2.5585 mL | 5.1169 mL | 6.3962 mL |
| 50 mM | 0.0512 mL | 0.2558 mL | 0.5117 mL | 1.0234 mL | 1.2792 mL |
| 100 mM | 0.0256 mL | 0.1279 mL | 0.2558 mL | 0.5117 mL | 0.6396 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Chlorpheniramine (Chlorpheniramine maleate, Chlorphenamine) is an histamine H1 receptor antagonist with IC50 of 12 nM.
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Stability-indicating High-performance Liquid Chromatography Method for Simultaneous Determination of Aminophylline and Chlorpheniramine Maleate in Pharmaceutical Formulations.[Pubmed:26798164]
Indian J Pharm Sci. 2015 Sep-Oct;77(5):515-21.
The present work deals with the development and validation of method for simultaneous determination of antihistaminic drugs in pharmaceutical formulations. A precise, specific and accurate reverse phase-high-performance liquid chromatography method for the simultaneous measurement of aminophylline and Chlorpheniramine Maleate was developed. The separation of drugs was achieved on C-18 (5 mum, 250x4.6 mm) high-performance liquid chromatography column. The runtime for analysis was 10 min. Mobile phase is mixture containing dilute H2SO4:methanol (60:40% v/v) with flow rate adjusted at 1.5 ml/min. The detection of components was performed at a wavelength of 264 nm. Retention times of aminophylline and chlorphinramine maleate were found to be 2.00 and 3.25 min, respectively. Linearity was found in the range of 16-24 mug/ml for Chlorpheniramine Maleate and 102.4-153.6 mug/ml for aminophylline with a correlation coefficient of 0.9998 and 0.9996, respectively. High peak purity index of 99.99% indicated the complete separation of analytes in the presence of degradation products is justification of method stability. Linearity, accuracy, specificity, precision and robustness studies were performed for method validation.
Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures.[Pubmed:28223869]
Saudi Pharm J. 2017 Jan;25(1):99-103.
Paracetamol (PAR), phenylephrine hydrochloride (PHE) and Chlorpheniramine Maleate (CPM) are commonly used in clinical practice as antipyretic and analgesic drugs to ameliorate pain and fever in cold and flu conditions. The present work describes the use of thermal analysis for the characterization of the physicochemical compatibility between drugs and excipients during the development of solid dosage forms. Thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC) were used to study the thermal stability of the drug and of the physical mixture (drug/excipients) in solid binary mixtures (1:1). DSC thermograms demonstrated reproducible melting event of the prepared physical mixture. Starch, mannitol, lactose and magnesium stearate influence thermal parameters. Information recorded from the derivative thermogravimetric (DTG) and TGA curves demonstrated the decomposition of drugs in well-defined thermal events, translating the suitability of these techniques for the characterization of the drug/excipients interactions.
Validated RP-HPLC method for simultaneous determination and quantification of chlorpheniramine maleate, paracetamol and caffeine in tablet formulation.[Pubmed:27330891]
Springerplus. 2016 May 14;5:625.
Chlorpheniramine Maleate-paracetamol-caffeine tablet formulation is one of the common over-the-counter drugs used for the treatment of cold and cough. A reversed-phase high-performance liquid-chromatography method has been successfully developed for the simultaneous determination of Chlorpheniramine Maleate, paracetamol and caffeine in a drug formulation. The RP-HPLC method employed a Phenomenex C18 reversed phase column (Luna 5micro, 250 x 4.6 mm) with an isocratic mixture of methanol and 0.05 M dibasic phosphate buffer pH 4.0 in the ratio of (30:70; v/v) as the mobile phase. The column temperature was kept at 30 degrees C. The flow rate was 1.0 mL/min and detection was by means of a UV detector at wavelength of 215 nm. All the active components were successfully eluted with mean retention times of 2.4, 4.2, 7.2 min for Chlorpheniramine Maleate, paracetamol and caffeine respectively. The method was found to be linear (R(2) > 0.99), precise (RSD < 2.0 %), accurate (recoveries 97.9-102.8 %), specific, simple, sensitive, rapid and robust. The validated method can be used in routine quality control analysis of fixed dose combination tablets containing Chlorpheniramine Maleate, paracetamol and caffeine without any interference by excipients.
