Home >> Research Area >>Natural Products>>Diterpenoids>> 7-O-Methylrosmanol

7-O-Methylrosmanol

CAS# 113085-62-4

7-O-Methylrosmanol

Catalog No. BCN7276----Order now to get a substantial discount!

Product Name & Size Price Stock
7-O-Methylrosmanol: 5mg $690 In Stock
7-O-Methylrosmanol: 10mg Please Inquire In Stock
7-O-Methylrosmanol: 20mg Please Inquire Please Inquire
7-O-Methylrosmanol: 50mg Please Inquire Please Inquire
7-O-Methylrosmanol: 100mg Please Inquire Please Inquire
7-O-Methylrosmanol: 200mg Please Inquire Please Inquire
7-O-Methylrosmanol: 500mg Please Inquire Please Inquire
7-O-Methylrosmanol: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of 7-O-Methylrosmanol

Number of papers citing our products

Chemical structure

7-O-Methylrosmanol

3D structure

Chemical Properties of 7-O-Methylrosmanol

Cas No. 113085-62-4 SDF Download SDF
PubChem ID 23243692 Appearance Powder
Formula C21H28O5 M.Wt 360.45
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1R,8S,9S,10S)-3,4-dihydroxy-8-methoxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadeca-2,4,6-trien-15-one
SMILES CC(C)C1=C(C(=C2C(=C1)C(C3C4C2(CCCC4(C)C)C(=O)O3)OC)O)O
Standard InChIKey XNPVHIQPSAZTLC-NYUBLWNDSA-N
Standard InChI InChI=1S/C21H28O5/c1-10(2)11-9-12-13(15(23)14(11)22)21-8-6-7-20(3,4)18(21)17(16(12)25-5)26-19(21)24/h9-10,16-18,22-23H,6-8H2,1-5H3/t16-,17+,18-,21-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 7-O-Methylrosmanol

The herbs of Rosmarinus officinalis

Biological Activity of 7-O-Methylrosmanol

Description1. 7-O-methylrosmanol can effectively suppress FSK-induced luciferase expression under the control of the CRE, PEPCK-C and G6Pase gene promoters, it may contribute to its antihyperglycemic activity.
TargetscAMP

7-O-Methylrosmanol Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

7-O-Methylrosmanol Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of 7-O-Methylrosmanol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7743 mL 13.8715 mL 27.7431 mL 55.4862 mL 69.3577 mL
5 mM 0.5549 mL 2.7743 mL 5.5486 mL 11.0972 mL 13.8715 mL
10 mM 0.2774 mL 1.3872 mL 2.7743 mL 5.5486 mL 6.9358 mL
50 mM 0.0555 mL 0.2774 mL 0.5549 mL 1.1097 mL 1.3872 mL
100 mM 0.0277 mL 0.1387 mL 0.2774 mL 0.5549 mL 0.6936 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on 7-O-Methylrosmanol

Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays [corrected].[Pubmed:8229021]

J Nat Prod. 1993 Aug;56(8):1426-30.

In order to find new effective HIV protease inhibitors, two diterpenes (carnosic acid [1] and carnosol [5]) were isolated from rosemary (Rosmarinus officinalis L.), and rosmanol [2] and semisynthetic derivatives (7-O-Methylrosmanol [3], 7-O-ethylrosmanol [4], and 11,12-O,O-dimethylcarnosol [6]) were prepared. The inhibitory activity of all six compounds against HIV-1 protease was tested. The carnosic acid [1] showed the strongest inhibitory effect (IC90 = 0.08 micrograms/ml). The same compound was also assayed against HIV-1 virus replication (IC90 = 0.32 micrograms/ml). The cytotoxic TC90 on H9 lymphocytes was 0.36 micrograms/ml, which is very close to the effective antiviral dose. Additionally, the tested compounds did not inhibit cellular aspartic proteases cathepsin D and pepsin at the concentration range up to 10 micrograms/ml [corrected].

Phenolic diterpenes from rosemary suppress cAMP responsiveness of gluconeogenic gene promoters.[Pubmed:22927089]

Phytother Res. 2013 Jun;27(6):906-10.

The cAMP/protein kinase A/cAMP response element (CRE)-binding protein pathway is important for various physiological aspects including regulation of gluconeogenic gene expression. Rosemary, a well-known herb, has been reported to decrease blood glucose levels. We found that methanol extracts of rosemary suppressed forskolin (FSK)-stimulated luciferase expression under the control of CRE, as well as the promoters for cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) and glucose-6-phosphatase (G6Pase) catalytic subunit genes in human hepatoma HepG2 cells. Three abietane-type diterpenes and two flavonoids were isolated from the rosemary extracts. Among these, 7-O-Methylrosmanol (1) and royleanonic acid (3) effectively suppressed FSK-induced luciferase expression under the control of the CRE, PEPCK-C and G6Pase gene promoters. PEPCK-C and G6Pase, which play a key role in the homeostatic regulation of blood glucose levels, are important for managing type II diabetes mellitus. Therefore, the ability of rosemary and its components to suppress cAMP responsiveness of the PEPCK-C or G6Pase gene may contribute to its antihyperglycemic activity.

Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.[Pubmed:19711987]

J Nat Prod. 2009 Aug;72(8):1385-9.

The new aromatic diterpenes 7beta-O-benzylrosmanol (3), 7beta-O-benzyl-11,12-di-O-methylrosmanol (4), and 7alpha-thiophenylcarnosic acid (5) have been obtained by partial synthesis from carnosol (1), an abundant natural diterpene present in Salvia species. The structures of these compounds were established from their physical and spectroscopic data. The known diterpenes sagequinone methide A (6), 7beta-O-methylrosmanol (7), 7-O-Methylrosmanol (8), and rosmaquinone B (9) were obtained from rosmanol (2). The spectroscopic data of these semisynthetic diterpenes were identical to data reported in the literature. In addition, the new semisynthetic isorosmaquinone (10) was obtained from isorosmanol (12). The proton resonances of rosmaquinone (11) are reassigned based on 2D NMR spectroscopy. These compounds, as well as eight known analogues, were evaluated for cytotoxic and antimicrobial activities.

Keywords:

7-O-Methylrosmanol,113085-62-4,Natural Products, buy 7-O-Methylrosmanol , 7-O-Methylrosmanol supplier , purchase 7-O-Methylrosmanol , 7-O-Methylrosmanol cost , 7-O-Methylrosmanol manufacturer , order 7-O-Methylrosmanol , high purity 7-O-Methylrosmanol

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: