4'-DemethylpodophyllotoxinCAS# 40505-27-9 |
- 4'-Demethylepipodophyllotoxin
Catalog No.:BCN5918
CAS No.:6559-91-7
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 40505-27-9 | SDF | Download SDF |
| PubChem ID | 122667 | Appearance | Cryst. |
| Formula | C21H20O8 | M.Wt | 400.37 |
| Type of Compound | Lignans | Storage | Desiccate at -20°C |
| Solubility | DMSO : 250 mg/mL (624.41 mM; Need ultrasonic) | ||
| Chemical Name | (5R,5aR,8aR,9R)-5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one | ||
| SMILES | COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O | ||
| Standard InChIKey | YVCVYCSAAZQOJI-BTINSWFASA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 4'-Demethylpodophyllotoxin exhibits the remarkable cytotoxic potential in diverse cancer cell lines. |
| In vitro | 4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells.[Pubmed: 25446499]Chem Biol Interact. 2014 Oct 18;224C:100-107.We investigated the root of Podophyllum hexandrum as a potential source of lead bioactive metabolites with anticancer activity. |
4'-Demethylpodophyllotoxin Dilution Calculator
4'-Demethylpodophyllotoxin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4977 mL | 12.4884 mL | 24.9769 mL | 49.9538 mL | 62.4422 mL |
| 5 mM | 0.4995 mL | 2.4977 mL | 4.9954 mL | 9.9908 mL | 12.4884 mL |
| 10 mM | 0.2498 mL | 1.2488 mL | 2.4977 mL | 4.9954 mL | 6.2442 mL |
| 50 mM | 0.05 mL | 0.2498 mL | 0.4995 mL | 0.9991 mL | 1.2488 mL |
| 100 mM | 0.025 mL | 0.1249 mL | 0.2498 mL | 0.4995 mL | 0.6244 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells.[Pubmed:25446499]
Chem Biol Interact. 2014 Dec 5;224:100-7.
We investigated the root of Podophyllum hexandrum as a potential source of lead bioactive metabolites with anticancer activity. The present study led to the isolation of six known aryltetralin-type lignans designated as 4'-demethyl-deoxypodophyllotoxin (1), podophyllotoxin (2), 4'-demethyl-podophyllotoxin (3), podophyllotoxin-4-O-beta-d-glucopyranoside (4), 4'-demethyl-deoxypodophyllotoxin-4-O-beta-d-glucopyranoside (5), 4'-demethyl-podophyllotoxin-4-O-beta-d-glucopyranoside (6), along with three known flavones Kaempferol (7), Quercetin (8), Astragalin (9) from the root of P. hexandrum. Compounds (1-9) exhibited the remarkable cytotoxic potential in diverse cancer cell lines. 5 therapeutic potential was extensively studied first time which exhibiting antiproliferative and ROS generating activity than its non-glycoside analogue 1. Furthermore, 5 augmented the apoptotic cascades in MCF-7 breast cancer cells, viz. nuclear condensation, membrane blebbing, probably by destabilizing the micro-tubular protein tubulin. Strikingly, our docking study and in vitro assays demonstrate that 5 binds to and modulate checkpoint kinase-2, a key cell cycle regulatory protein in normal and cancer cells.
