6-HydroxykaempferolCAS# 4324-55-4 |
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| Cas No. | 4324-55-4 | SDF | Download SDF |
| PubChem ID | 5281638 | Appearance | Yellow powder |
| Formula | C15H10O7 | M.Wt | 302.2 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3,5,6,7-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one | ||
| SMILES | C1=CC(=CC=C1C2=C(C(=O)C3=C(C(=C(C=C3O2)O)O)O)O)O | ||
| Standard InChIKey | LFPHMXIOQBBTSS-UHFFFAOYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Inula japonica Thunb.
| Description | 1. 6-Hydroxykaempferol is a competitive inhibitor of tyrosinase compared to L-DOPA, it shows also high antioxidant activities. |
| Targets | Tyrosinase |
6-Hydroxykaempferol Dilution Calculator
6-Hydroxykaempferol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3091 mL | 16.5453 mL | 33.0907 mL | 66.1813 mL | 82.7267 mL |
| 5 mM | 0.6618 mL | 3.3091 mL | 6.6181 mL | 13.2363 mL | 16.5453 mL |
| 10 mM | 0.3309 mL | 1.6545 mL | 3.3091 mL | 6.6181 mL | 8.2727 mL |
| 50 mM | 0.0662 mL | 0.3309 mL | 0.6618 mL | 1.3236 mL | 1.6545 mL |
| 100 mM | 0.0331 mL | 0.1655 mL | 0.3309 mL | 0.6618 mL | 0.8273 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase.[Pubmed:17693955]
Molecules. 2007 Jan 29;12(1):86-97.
Baicalein (1), 6-hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxy-kaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxy-flavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA, while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor to monophenolase. Moreover, 6-Hydroxykaempferol (14) showed the highest activity and was a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7-Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities. Hence, we conclude that the 5,6,7-trihydroxy-flavones are useful as good depigmentation agents with inhibitory effects in addition to their antioxidant properties.
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