(6E,12E)-Tetradeca-6,12-diene-8,10-diyne-1,3-diol diacetateCAS# 89913-46-2 |
Quality Control & MSDS
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| Cas No. | 89913-46-2 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Oil |
| Formula | C18H22O4 | M.Wt | 302.4 |
| Type of Compound | Other NPs | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
(6E,12E)-Tetradeca-6,12-diene-8,10-diyne-1,3-diol diacetate Dilution Calculator
(6E,12E)-Tetradeca-6,12-diene-8,10-diyne-1,3-diol diacetate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3069 mL | 16.5344 mL | 33.0688 mL | 66.1376 mL | 82.672 mL |
| 5 mM | 0.6614 mL | 3.3069 mL | 6.6138 mL | 13.2275 mL | 16.5344 mL |
| 10 mM | 0.3307 mL | 1.6534 mL | 3.3069 mL | 6.6138 mL | 8.2672 mL |
| 50 mM | 0.0661 mL | 0.3307 mL | 0.6614 mL | 1.3228 mL | 1.6534 mL |
| 100 mM | 0.0331 mL | 0.1653 mL | 0.3307 mL | 0.6614 mL | 0.8267 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Application of Centrifugal Partition Chromatography for Bioactivity-Guided Purification of Antioxidant-Response-Element-Inducing Constituents from Atractylodis Rhizoma Alba.[Pubmed:30200578]
Molecules. 2018 Sep 6;23(9). pii: molecules23092274.
Activity-guided separation of antioxidant response element (ARE)-inducing constituents from the rhizomes of Atractylodis Rhizoma Alba was performed by the combination of centrifugal partition chromatography (CPC) and an ARE luciferase reporter assay. From 3 g of the active n-hexane fraction, one polyacetylene, (6E,12E)-tetradeca-6,12-dien-8,10-diyne-1,3-diyl diacetate (47.3 mg), and two sesquiterpenes, atractylenolide I (40.9 mg), and selina-4(14),7(11)-dien-8-one (6.0 mg) were successfully isolated by CPC with n-hexane(-)ethyl acetate(-)methanol(-)water (8:2:8:2, v/v). The chemical structures of the isolated compounds were determined by (1)H- and (13)C-NMR and ESI-MS. Among the isolated compounds, (6E,12E)-Tetradeca-6,12-diene-8,10-diyne-1,3-diol diacetate and selina-4(14),7(11)-dien-8-one increased ARE activity 32.9-fold and 16.6-fold, respectively, without significant cytotoxicity, when 5 microM sulforaphane enhanced ARE activity 27.1-fold. However, atractylenolide I did not increase ARE activity at 100 microM, and showed cytotoxicity at concentrations over 10 microM.
Antibacterial activity of phytochemicals isolated from Atractylodes japonica against methicillin-resistant Staphylococcus aureus.[Pubmed:20966880]
Molecules. 2010 Oct 21;15(10):7395-402.
Methicillin-resistant Staphylococcus aureus (MRSA) has been emerging worldwide as one of the most important problems in communities and hospitals. Therefore, new agents are needed to treat acute oral infections from MRSA. In this study, antibacterial compounds from the roots of Atractylodes japonica (A. japonica) were isolated and characterized. The compounds were isolated from the root extracts using HPLC-piloted activity-guided fractionations. Four A. japonica compounds were isolated and identified as atractylenolide III (1), atractylenolide I (2), diacetylatractylodiol [(6E,12E)-Tetradeca-6,12-diene-8,10-diyne-1,3-diol diacetate, TDEYA, 3). and (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol (TDEA, 4), which was obtained by hydrolysis of TDEYA. The minimum inhibitory concentrations (MICs) was determined in the setting of clinical MRSA isolates. Compound 4 showed anti-MRSA activity with a MIC value of 4-32 mug/mL. The overall results provide promising baseline information for the potential use of the extract of A. japonica as well as some of the isolated compounds in the treatment of bacterial infections.
