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7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one

CAS# 100667-52-5

7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one

Catalog No. BCN8795----Order now to get a substantial discount!

Product Name & Size Price Stock
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one: 5mg $725 In Stock
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one: 10mg Please Inquire In Stock
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one: 20mg Please Inquire Please Inquire
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7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one: 100mg Please Inquire Please Inquire
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7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one: 500mg Please Inquire Please Inquire
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one: 1000mg Please Inquire Please Inquire

Quality Control of 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one

Number of papers citing our products

Chemical structure

7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one

3D structure

Chemical Properties of 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one

Cas No. 100667-52-5 SDF Download SDF
PubChem ID 69757384 Appearance Oil
Formula C19H20O2 M.Wt 280.4
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one
SMILES C1=CC=C(C=C1)CCC(=O)C=CCCC2=CC=C(C=C2)O
Standard InChIKey VPCHZECKYCDVSA-UHFFFAOYSA-N
Standard InChI InChI=1S/C19H20O2/c20-18(13-10-16-6-2-1-3-7-16)9-5-4-8-17-11-14-19(21)15-12-17/h1-3,5-7,9,11-12,14-15,21H,4,8,10,13H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one

The rhizoma of Curcuma longa L.

Biological Activity of 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one

Description7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of Alzheimer's disease (AD).
TargetsAmyloid-β | PI3K | mTOR
In vitro

7-(4-Hydroxyphenyl)-1-phenyl-4E-hepten-3-one, a Diarylheptanoid from Alpinia officinarum, Protects Neurons against Amyloid-β Induced Toxicity.[Pubmed: 27615431 ]

Biol Pharm Bull. 2016 Dec 1;39(12):1961-1967.

Amyloid-β (Aβ) is one of the major causative agents of Alzheimer's disease (AD), the most common neurodegenerative disorder characterized by progressive cognitive impairment. While effective drugs for AD are currently limited, identifying anti-Aβ compounds from natural products has been shown as a promising strategy which may lead to breakthroughs for new drug candidate discovery. We have previously reported that 7-(4-hydroxyphenyl)-1-phenyl-4E-hepten-3-one (7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one ,AO-1), a diarylheptanoid extracted from the plant Alpinia officinarum, has strong effects on neuronal differentiation and neurite outgrowth in vitro and in vivo.
METHODS AND RESULTS:
The present study further uncovers that AO-1 exerts neuroprotective effects against the neurotoxicity caused by Aβ. Under the damage of Aβ oligomers, the major pathological forms of Aβ, dendrites of neurons become atrophic and simplified, but such impairments were substantially alleviated by AO-1 treatment. Moreover, AO-1 reduced apoptotic levels and oxidative stress triggered by Aβ. Further analysis showed that the anti-caspase and dendrite protective effects of AO-1 were dependent on activation of phosphatidylinositol 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) pathways.
CONCLUSIONS:
These findings collectively identify AO-1 as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of AD.

7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one Dilution Calculator

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7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one Molarity Calculator

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Preparing Stock Solutions of 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5663 mL 17.8317 mL 35.6633 mL 71.3267 mL 89.1583 mL
5 mM 0.7133 mL 3.5663 mL 7.1327 mL 14.2653 mL 17.8317 mL
10 mM 0.3566 mL 1.7832 mL 3.5663 mL 7.1327 mL 8.9158 mL
50 mM 0.0713 mL 0.3566 mL 0.7133 mL 1.4265 mL 1.7832 mL
100 mM 0.0357 mL 0.1783 mL 0.3566 mL 0.7133 mL 0.8916 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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