7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-oneCAS# 100667-52-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 100667-52-5 | SDF | Download SDF |
PubChem ID | 69757384 | Appearance | Oil |
Formula | C19H20O2 | M.Wt | 280.4 |
Type of Compound | Phenols | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one | ||
SMILES | C1=CC=C(C=C1)CCC(=O)C=CCCC2=CC=C(C=C2)O | ||
Standard InChIKey | VPCHZECKYCDVSA-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C19H20O2/c20-18(13-10-16-6-2-1-3-7-16)9-5-4-8-17-11-14-19(21)15-12-17/h1-3,5-7,9,11-12,14-15,21H,4,8,10,13H2 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of Alzheimer's disease (AD). |
Targets | Amyloid-β | PI3K | mTOR |
In vitro | 7-(4-Hydroxyphenyl)-1-phenyl-4E-hepten-3-one, a Diarylheptanoid from Alpinia officinarum, Protects Neurons against Amyloid-β Induced Toxicity.[Pubmed: 27615431 ]Biol Pharm Bull. 2016 Dec 1;39(12):1961-1967.Amyloid-β (Aβ) is one of the major causative agents of Alzheimer's disease (AD), the most common neurodegenerative disorder characterized by progressive cognitive impairment. While effective drugs for AD are currently limited, identifying anti-Aβ compounds from natural products has been shown as a promising strategy which may lead to breakthroughs for new drug candidate discovery. We have previously reported that 7-(4-hydroxyphenyl)-1-phenyl-4E-hepten-3-one (7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
,AO-1), a diarylheptanoid extracted from the plant Alpinia officinarum, has strong effects on neuronal differentiation and neurite outgrowth in vitro and in vivo. |
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one Dilution Calculator
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 3.5663 mL | 17.8317 mL | 35.6633 mL | 71.3267 mL | 89.1583 mL |
5 mM | 0.7133 mL | 3.5663 mL | 7.1327 mL | 14.2653 mL | 17.8317 mL |
10 mM | 0.3566 mL | 1.7832 mL | 3.5663 mL | 7.1327 mL | 8.9158 mL |
50 mM | 0.0713 mL | 0.3566 mL | 0.7133 mL | 1.4265 mL | 1.7832 mL |
100 mM | 0.0357 mL | 0.1783 mL | 0.3566 mL | 0.7133 mL | 0.8916 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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