PlatyphyllenoneCAS# 56973-65-0 |
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| Cas No. | 56973-65-0 | SDF | Download SDF |
| PubChem ID | 23786382 | Appearance | Oil |
| Formula | C19H20O3 | M.Wt | 296.4 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (E)-1,7-bis(4-hydroxyphenyl)hept-4-en-3-one | ||
| SMILES | C1=CC(=CC=C1CCC=CC(=O)CCC2=CC=C(C=C2)O)O | ||
| Standard InChIKey | GIKJADRKBZHVCY-DUXPYHPUSA-N | ||
| Standard InChI | InChI=1S/C19H20O3/c20-17(10-7-16-8-13-19(22)14-9-16)4-2-1-3-15-5-11-18(21)12-6-15/h2,4-6,8-9,11-14,21-22H,1,3,7,10H2/b4-2+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Platyphyllenone has shown promising anti-filarial activity both in vitro and in vivo studies. 2. Platyphyllenone and hirsutenone can inhibit the biosynthesis of violacein in C. violaceum CV026. |
| Targets | Antifection |
Platyphyllenone Dilution Calculator
Platyphyllenone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3738 mL | 16.8691 mL | 33.7382 mL | 67.4764 mL | 84.3455 mL |
| 5 mM | 0.6748 mL | 3.3738 mL | 6.7476 mL | 13.4953 mL | 16.8691 mL |
| 10 mM | 0.3374 mL | 1.6869 mL | 3.3738 mL | 6.7476 mL | 8.4345 mL |
| 50 mM | 0.0675 mL | 0.3374 mL | 0.6748 mL | 1.3495 mL | 1.6869 mL |
| 100 mM | 0.0337 mL | 0.1687 mL | 0.3374 mL | 0.6748 mL | 0.8435 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antifilarial diarylheptanoids from Alnus nepalensis leaves growing in high altitude areas of Uttarakhand, India.[Pubmed:23219341]
Phytomedicine. 2013 Jan 15;20(2):124-32.
Lymphatic filariasis continues to be a major health problem in tropical and subtropical countries. A macrofilaricidal agent capable of eliminating adult filarial parasites is urgently needed. Platyphyllenone (A), alusenone (B), hirustenone (C) and hirsutanonol (D) are important biologically active diarylheptanoids present in Alnus nepalensis. In the present study, we report the antifilarial activity in diarylheptanoids isolated from the leaves of A. nepalensis. Out of four compounds (A-D) tested in vitro one has shown promising anti-filarial activity both in vitro and in vivo studies. This is the first ever report on antifilarial efficacy of a compound of the plant and warrants further studies around this scaffold. In addition, a sensitive, selective and robust densitometric high-performance thin-layer chromatographic method was developed and validated for the above four biomarker compounds. The separation was performed on silica gel 60F(254) high-performance thin layer chromatography plates using chloroform:methanol (9:1, v/v) as mobile phase. The quantitation of marker compounds was carried out using densitometric reflection/absorption mode at 600 nm after post-chromatographic derivatization using vanillin-sulfuric acid reagent. The method was validated for peak purity, precision, robustness, limit of detection (LOD) and quantitation (LOQ) etc., as per the International Conference on Harmonization (ICH) guidelines.
