Sterebin A

CAS# 107647-14-3

Sterebin A

Catalog No. BCN8802----Order now to get a substantial discount!

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Sterebin A: 5mg $512 In Stock
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Quality Control of Sterebin A

Number of papers citing our products

Chemical structure

Sterebin A

3D structure

Chemical Properties of Sterebin A

Cas No. 107647-14-3 SDF Download SDF
PubChem ID 71694416 Appearance Powder
Formula C18H30O4 M.Wt 310.43
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (E)-4-[(1R,2S,3S,4R,8aS)-2,3,4-trihydroxy-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]but-3-en-2-one
SMILES CC(=O)C=CC1C2(CCCC(C2C(C(C1(C)O)O)O)(C)C)C
Standard InChIKey GUVJPXABQYFWPD-GSZDNMEJSA-N
Standard InChI InChI=1S/C18H30O4/c1-11(19)7-8-12-17(4)10-6-9-16(2,3)14(17)13(20)15(21)18(12,5)22/h7-8,12-15,20-22H,6,9-10H2,1-5H3/b8-7+/t12-,13-,14?,15+,17-,18+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Sterebin A

The leaves of Stevia rebaudiana

Biological Activity of Sterebin A

DescriptionSterebin A may have anti-inflammatory activity.

Protocol of Sterebin A

Structure Identification
European Food Research and Technology. A, 2007, 224(4):483-488.

Phytochemical and biological investigationOf Stevia rebaudiana Bertoni; 1-labdane-type diterpene.[Reference: WebLink]


METHODS AND RESULTS:
Five labdane diterpenoids, austroinulin, iso-austroinulin, sterebin E, sterebin E acetate, and Sterebin A acetate, along with hydrocarbons, aliphatic alcohols, beta-amyrin, beta-sitosterol and stigmasterol were isolated from the chloroform soluble fraction of the methanol extract of Stevia rebaudiana leaves. Chlorogenic and caffeic acids were isolated from the EtOAc fraction.
CONCLUSIONS:
All the isolated compounds were identified using spectral tools. The chloroform and methanol extracts proved significant anti-inflammatory effect and caused marked inhibition of carrageenan-induced paw oedema in rats.

Sterebin A Dilution Calculator

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Sterebin A Molarity Calculator

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Preparing Stock Solutions of Sterebin A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2213 mL 16.1067 mL 32.2134 mL 64.4268 mL 80.5335 mL
5 mM 0.6443 mL 3.2213 mL 6.4427 mL 12.8854 mL 16.1067 mL
10 mM 0.3221 mL 1.6107 mL 3.2213 mL 6.4427 mL 8.0533 mL
50 mM 0.0644 mL 0.3221 mL 0.6443 mL 1.2885 mL 1.6107 mL
100 mM 0.0322 mL 0.1611 mL 0.3221 mL 0.6443 mL 0.8053 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Sterebin A

Diterpenoids and Bisnorditerpenoids from Blumea aromatica.[Pubmed:31646857]

J Nat Prod. 2019 Nov 22;82(11):3181-3185.

Three new labdane-type diterpenoids, 6alpha-O-isovalerylnidorellol (1), (12S)-blumdane (2), and (12R)-epiblumdane (3), and three new bisnorditerpenoids, 6alpha-O-(3-methyl-2-butenoyl)Sterebin A (5), 6alpha-O-angeloylSterebin A (6), and 6alpha-O-isovalerylSterebin A (7), plus 17 known compounds were isolated from Blumea aromatica. Their structures of the new compounds were proposed by detailed spectroscopic analysis. The absolute configuration at C-12 of blumdane (2) was determined by the modified Mosher's method. The anti-inflammatory and anti-immunosuppressive effects of these isolated compounds were assessed. Compounds 9, 16, and 23 (at 40 muM) showed a slight suppression of TNF-alpha production, but no or little effect on the expression of PD-L1 in granulocytic myeloid-derived suppressor cells was observed for all test compounds.

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