Heishuixiecaoline ACAS# 1469493-85-3 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1469493-85-3 | SDF | Download SDF |
| PubChem ID | 138111540 | Appearance | Powder |
| Formula | C17H24O3 | M.Wt | 276.37 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | [(1S,10R)-8-formyl-4,11,11-trimethyl-2-bicyclo[8.1.0]undeca-4,8-dienyl] acetate | ||
| SMILES | CC1=CCCC(=CC2C(C2(C)C)C(C1)OC(=O)C)C=O | ||
| Standard InChIKey | WDPMIKJGUYMIBS-YTPLPTRZSA-N | ||
| Standard InChI | InChI=1S/C17H24O3/c1-11-6-5-7-13(10-18)9-14-16(17(14,3)4)15(8-11)20-12(2)19/h6,9-10,14-16H,5,7-8H2,1-4H3/t14-,15?,16-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Heishuixiecaoline A protects against neurotoxicity in PC12 cells. |
| In vitro | Compounds from the roots and rhizomes of Valeriana amurensis protect against neurotoxicity in PC12 cells.[Pubmed: 23250029]Molecules. 2012 Dec 18;17(12):15013-21.
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Heishuixiecaoline A Dilution Calculator
Heishuixiecaoline A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.6183 mL | 18.0917 mL | 36.1834 mL | 72.3668 mL | 90.4584 mL |
| 5 mM | 0.7237 mL | 3.6183 mL | 7.2367 mL | 14.4734 mL | 18.0917 mL |
| 10 mM | 0.3618 mL | 1.8092 mL | 3.6183 mL | 7.2367 mL | 9.0458 mL |
| 50 mM | 0.0724 mL | 0.3618 mL | 0.7237 mL | 1.4473 mL | 1.8092 mL |
| 100 mM | 0.0362 mL | 0.1809 mL | 0.3618 mL | 0.7237 mL | 0.9046 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Compounds from the roots and rhizomes of Valeriana amurensis protect against neurotoxicity in PC12 cells.[Pubmed:23250029]
Molecules. 2012 Dec 18;17(12):15013-21.
Three new germacrane-type sesquiterpenoids, Heishuixiecaoline A-C (compounds 1-3), were isolated along with ten known compounds 4-13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer's disease (AD). The structures of 1-3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 1-13 on the neurotoxicity of PC12 cells induced by amyloid-beta (Abeta(25-25)), respectively. As a result, germacrane-type sesquiterpenoids 1-4 and lignans 5-7 were seen to afford protection against Abeta-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD.
