7-Oxo-ganoderic acid ZCAS# 929248-72-6 |
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| Cas No. | 929248-72-6 | SDF | Download SDF |
| PubChem ID | 71461154 | Appearance | Powder |
| Formula | C30H46O4 | M.Wt | 470.68 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (E,6R)-6-[(3S,5R,10S,13R,14R,17R)-3-hydroxy-4,4,10,13,14-pentamethyl-7-oxo-1,2,3,5,6,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-methylhept-2-enoic acid | ||
| SMILES | CC(CCC=C(C)C(=O)O)C1CCC2(C1(CCC3=C2C(=O)CC4C3(CCC(C4(C)C)O)C)C)C | ||
| Standard InChIKey | ZNDCXCGTAALLTP-DKYKKQJNSA-N | ||
| Standard InChI | InChI=1S/C30H46O4/c1-18(9-8-10-19(2)26(33)34)20-11-16-30(7)25-21(12-15-29(20,30)6)28(5)14-13-24(32)27(3,4)23(28)17-22(25)31/h10,18,20,23-24,32H,8-9,11-17H2,1-7H3,(H,33,34)/b19-10+/t18-,20-,23+,24+,28-,29-,30+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The fruit body of Ganoderma lucidum
| Description | 1. 7-Oxo-ganoderic acid Z shows strong inhibitory effects against α-glucosidase. 2. 7-Oxo-ganoderic acid Z can reduce cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependently with LC50s from 20.87 to 84.36 uM. 3. 7-Oxo-ganoderic acid Z exhibits inhibitory activities against the HMG-CoA reductase and acyl CoA acyltransferase. |
| Targets | HMG-CoA Reductase |
7-Oxo-ganoderic acid Z Dilution Calculator
7-Oxo-ganoderic acid Z Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1246 mL | 10.6229 mL | 21.2459 mL | 42.4917 mL | 53.1146 mL |
| 5 mM | 0.4249 mL | 2.1246 mL | 4.2492 mL | 8.4983 mL | 10.6229 mL |
| 10 mM | 0.2125 mL | 1.0623 mL | 2.1246 mL | 4.2492 mL | 5.3115 mL |
| 50 mM | 0.0425 mL | 0.2125 mL | 0.4249 mL | 0.8498 mL | 1.0623 mL |
| 100 mM | 0.0212 mL | 0.1062 mL | 0.2125 mL | 0.4249 mL | 0.5311 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against alpha-glucosidase.[Pubmed:29490285]
Phytochemistry. 2018 May;149:103-115.
Eighteen previously undescribed lanostane triterpenes and thirty known analogues were obtained from the fruiting bodies of Ganoderma resinaceum. Resinacein C was isolated from a natural source for the first time. The structures of all the above compounds were elucidated by extensive spectroscopic analysis and comparisons of their spectroscopic data with those reported in the literature. Furthermore, in an in vitro assay, Resinacein C, ganoderic acid Y, lucialdehyde C, 7-Oxo-ganoderic acid Z3, 7-Oxo-ganoderic acid Z, and lucidadiol showed strong inhibitory effects against alpha-glucosidase compared with the positive control drug acarbose. The structure-activity relationships of ganoderma triterpenes on alpha-glucosidase inhibition showed that the C-24/C-25 double bond is necessary for alpha-glucosidase inhibitory activity. Moreover, the carboxylic acid group at C-26 and the hydroxy group at C-15 play important roles in enhancing inhibitory effects of these triterpenes.
New ganoderic acids, bioactive triterpenoid metabolites from the mushroom Ganoderma lucidum.[Pubmed:17050181]
Nat Prod Res. 2006 Sep;20(11):985-91.
Two new lanostanoids, 7-Oxo-ganoderic acid Z (1) and 15-hydroxy-ganoderic acid S (2), were isolated from a lipophilic extract of the fruiting body of Ganoderma lucidum. The structures of both compounds were established by interpretation of their spectroscopic data. Compounds 1 and 2 both exhibited inhibitory activities against the HMG-CoA reductase and acyl CoA acyltransferase.
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