Cucumegastigmane ICAS# 929881-46-9 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 929881-46-9 | SDF | Download SDF |
| PubChem ID | 16105430 | Appearance | Powder |
| Formula | C13H20O4 | M.Wt | 240.3 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (4S)-4-[(E,3S)-3,4-dihydroxybut-1-enyl]-4-hydroxy-3,5,5-trimethylcyclohex-2-en-1-one | ||
| SMILES | CC1=CC(=O)CC(C1(C=CC(CO)O)O)(C)C | ||
| Standard InChIKey | CNLCQYMRNGWEJB-OERKHBLVSA-N | ||
| Standard InChI | InChI=1S/C13H20O4/c1-9-6-11(16)7-12(2,3)13(9,17)5-4-10(15)8-14/h4-6,10,14-15,17H,7-8H2,1-3H3/b5-4+/t10-,13+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Standard reference |
| In vitro | Chemical constituents of the Annona glabra fruit and their cytotoxic activity.[Pubmed: 25856711]Pharm Biol. 2015 Nov;53(11):1602-7.
Phytochemical and therapeutic potential of cucumber.[Pubmed: 23098877]Fitoterapia. 2013 Jan;84:227-36.The fruit is refrigerant, haemostatic, tonic and useful in hyperdipsia, thermoplegia etc. The seeds also have a cooling effect on the body and they are used to prevent constipation.
|
Cucumegastigmane I Dilution Calculator
Cucumegastigmane I Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.1615 mL | 20.8073 mL | 41.6146 mL | 83.2293 mL | 104.0366 mL |
| 5 mM | 0.8323 mL | 4.1615 mL | 8.3229 mL | 16.6459 mL | 20.8073 mL |
| 10 mM | 0.4161 mL | 2.0807 mL | 4.1615 mL | 8.3229 mL | 10.4037 mL |
| 50 mM | 0.0832 mL | 0.4161 mL | 0.8323 mL | 1.6646 mL | 2.0807 mL |
| 100 mM | 0.0416 mL | 0.2081 mL | 0.4161 mL | 0.8323 mL | 1.0404 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Sessilifoline A
Catalog No.:BCN4473
CAS No.:929637-35-4
- Bavisant dihydrochloride
Catalog No.:BCC1403
CAS No.:929622-09-3
- Bavisant
Catalog No.:BCC1402
CAS No.:929622-08-2
- Fmoc-Tyr-OH
Catalog No.:BCC3562
CAS No.:92954-90-0
- LUF 6283
Catalog No.:BCC6318
CAS No.:92933-48-7
- 7-Oxo-ganoderic acid Z
Catalog No.:BCN7973
CAS No.:929248-72-6
- GSK461364
Catalog No.:BCC3788
CAS No.:929095-18-1
- Pracinostat (SB939)
Catalog No.:BCC2152
CAS No.:929016-96-6
- DB07268
Catalog No.:BCC1519
CAS No.:929007-72-7
- PF-03716556
Catalog No.:BCC2084
CAS No.:928774-43-0
- IRAK inhibitor 2
Catalog No.:BCC1655
CAS No.:928333-30-6
- AS 1892802
Catalog No.:BCC6335
CAS No.:928320-12-1
- SGI-110
Catalog No.:BCC2221
CAS No.:929901-49-5
- 3,4-Dimethoxybenzyl Alcohol
Catalog No.:BCN2721
CAS No.:93-03-8
- 3,4-Dimethoxybenzoic acid
Catalog No.:BCN4475
CAS No.:93-07-2
- 2-Acetonaphthone
Catalog No.:BCC8510
CAS No.:93-08-3
- Guaifenesin
Catalog No.:BCN2977
CAS No.:93-14-1
- Methyleugenol
Catalog No.:BCN4074
CAS No.:93-15-2
- Methyl isoeugenol
Catalog No.:BCN8462
CAS No.:93-16-3
- N-(2-Methoxyphenyl)acetamide
Catalog No.:BCC9054
CAS No.:93-26-5
- Acetylisoeugenol
Catalog No.:BCN7075
CAS No.:93-29-8
- Umbelliferone
Catalog No.:BCN4477
CAS No.:93-35-6
- Skimmin
Catalog No.:BCN4479
CAS No.:93-39-0
- 1-Phenylbutane-1,3-dione
Catalog No.:BCN3807
CAS No.:93-91-4
Chemical constituents of the Annona glabra fruit and their cytotoxic activity.[Pubmed:25856711]
Pharm Biol. 2015;53(11):1602-7.
CONTEXT: Traditional Chinese medicines have attracted increasing interest as potential sources of novel drugs with a wide range of biological and pharmacological activities. Annona glabra Linn (Annonaceae) is used in traditional medicine as an anticancer drug. Phytochemical investigation of this plant led to the isolation of acetogenins, ent-kauranes, peptides, and alkaloids. In addition, compounds exhibited anticancer, anti-HIV-reserve, and antimalaria. OBJECTIVE: Isolation, structure determination, and cytotoxic activity evaluation of compounds from the methanol extract from A. glabra fruits. MATERIALS AND METHODS: Using chromatographic methods to isolate compounds from the A. glabra methanol extract. The cytotoxic activity of compounds was evaluated by a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. In addition, compounds which showed significant cytotoxic activity were chosen for further study apoptosis characteristics. RESULTS: One new, (2E,4E,1'R,3'S,5'R,6'S)-dihydrophaseic acid 1,3'-di-O-beta-d-glucopyranoside, and eight known compounds, (2E,4E,1'R,3'S,5'R,6'S)-dihydrophaseic acid 3'-O-beta-d-glucopyranoside (2), icariside D2 (3), icariside D2 6'-O-beta-d-xylopyranoside (4), 3,4-dimethoxyphenyl O-beta-d-glucopyranoside (5), 3,4-dihydroxybenzoic acid (6), blumenol A (7), Cucumegastigmane I (8), and icariside B1 (9), were isolated from the fruits of A. glabra. Icariside D2 (3) was found to show significant cytotoxic activity on the HL-60 cell line with the IC50 value of 9.0 +/- 1.0 microM and did not show cytotoxic activity on the Hel-299 normal cell line. The further test indicated that compound 3 induced apoptosis via alteration of expression of apoptosis-related proteins and decreased phosphorylation of AKT in HL-60 cells. DISCUSSION AND CONCLUSION: The results suggested that the constituents from A. glabra may contain effective compounds which can be used as anticancer agents.
