AZD 3988Potent and selective DGAT-1 inhibitor CAS# 892489-52-0 |
Related Products
- ASP3026
Catalog No.:BCC1372
CAS No.:1097917-15-1
- AP26113
Catalog No.:BCC1069
CAS No.:1197958-12-5
- ALK inhibitor 1
Catalog No.:BCC1339
CAS No.:761436-81-1
- ALK inhibitor 2
Catalog No.:BCC1340
CAS No.:761438-38-4
- (R)-Crizotinib
Catalog No.:BCC1284
CAS No.:877399-52-5
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 892489-52-0 | SDF | Download SDF |
| PubChem ID | 23648867 | Appearance | Powder |
| Formula | C23H22F2N4O4 | M.Wt | 456.44 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO and to 10 mM in 1eq. NaOH with gentle warming | ||
| Chemical Name | 2-[4-[4-[[5-(3,4-difluoroanilino)-1,3,4-oxadiazole-2-carbonyl]amino]phenyl]cyclohexyl]acetic acid | ||
| SMILES | C1CC(CCC1CC(=O)O)C2=CC=C(C=C2)NC(=O)C3=NN=C(O3)NC4=CC(=C(C=C4)F)F | ||
| Standard InChIKey | NGEBYTLALFOQKI-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C23H22F2N4O4/c24-18-10-9-17(12-19(18)25)27-23-29-28-22(33-23)21(32)26-16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-20(30)31/h5-10,12-14H,1-4,11H2,(H,26,32)(H,27,29)(H,30,31) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC50 = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable. |
AZD 3988 Dilution Calculator
AZD 3988 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1909 mL | 10.9543 mL | 21.9087 mL | 43.8174 mL | 54.7717 mL |
| 5 mM | 0.4382 mL | 2.1909 mL | 4.3817 mL | 8.7635 mL | 10.9543 mL |
| 10 mM | 0.2191 mL | 1.0954 mL | 2.1909 mL | 4.3817 mL | 5.4772 mL |
| 50 mM | 0.0438 mL | 0.2191 mL | 0.4382 mL | 0.8763 mL | 1.0954 mL |
| 100 mM | 0.0219 mL | 0.1095 mL | 0.2191 mL | 0.4382 mL | 0.5477 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Featured Products
- Manidipine 2HCl
Catalog No.:BCC4405
CAS No.:89226-75-5
- Manidipine
Catalog No.:BCC4404
CAS No.:89226-50-6
- LY2334737
Catalog No.:BCC4060
CAS No.:892128-60-8
- Mulberrofuran H
Catalog No.:BCN3371
CAS No.:89199-99-5
- Fraxiresinol 1-O-glucoside
Catalog No.:BCN4439
CAS No.:89199-94-0
- Efaroxan hydrochloride
Catalog No.:BCC6797
CAS No.:89197-00-2
- 15,16-Dihydrotanshindiol C
Catalog No.:BCN3214
CAS No.:891854-96-9
- 1,2-Didehydrocryptotanshinone
Catalog No.:BCN3122
CAS No.:891854-92-5
- 15,16-Dihydrotanshindiol B
Catalog No.:BCN3213
CAS No.:891854-86-7
- SCH900776 S-isomer
Catalog No.:BCC1936
CAS No.:891494-64-7
- MK-8776 (SCH-900776)
Catalog No.:BCC3817
CAS No.:891494-63-6
- Betulin caffeate
Catalog No.:BCN4438
CAS No.:89130-86-9
New Products
- 2-(Chloromethyl)-4-(4-nitrophenyl)-1,3-thiazole
Catalog No.:BCC8372
CAS No.:89250-26-0
- MF63
Catalog No.:BCC1744
CAS No.:892549-43-8
- 2,4-Dihydroxy-3-nitropyridine
Catalog No.:BCC8499
CAS No.:89282-12-2
- 3,4-O,O-Methylene-(+)-catechin
Catalog No.:BCN7962
CAS No.:89329-14-6
- ICI 174,864
Catalog No.:BCC5675
CAS No.:89352-67-0
- Chiisanoside
Catalog No.:BCN2712
CAS No.:89354-01-8
- Riligustilide
Catalog No.:BCC9136
CAS No.:89354-45-0
- PF 945863
Catalog No.:BCC6172
CAS No.:893556-85-9
- Imidapril HCl
Catalog No.:BCC3792
CAS No.:89396-94-1
- VU 0240551
Catalog No.:BCC5424
CAS No.:893990-34-6
- LDN 212320
Catalog No.:BCC6361
CAS No.:894002-50-7
- Raddeanin A
Catalog No.:BCN1084
CAS No.:89412-79-3
Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.[Pubmed:22608962]
Bioorg Med Chem Lett. 2012 Jun 15;22(12):3873-8.
A novel series of DGAT-1 inhibitors was discovered from an oxadiazole amide high throughput screening (HTS) hit. Optimisation of potency and ligand lipophilicity efficiency (LLE) resulted in a carboxylic acid containing clinical candidate 53 (AZD3988), which demonstrated excellent DGAT-1 potency (0.6 nM), good pharmacokinetics and pre-clinical in vivo efficacy that could be rationalised through a PK/PD relationship.
AZD3988 is a diacylglycerol acyl transferase-1 (DGAT-1) inhibitor with IC50s of 6, 5, 11 nM for human, rat, mouse, respectively.
AZD 3988,892489-52-0,Natural Products,DGAT, buy AZD 3988 , AZD 3988 supplier , purchase AZD 3988 , AZD 3988 cost , AZD 3988 manufacturer , order AZD 3988 , high purity AZD 3988
