SCH900776 S-isomerCheckpoint kinase(Chk)inhibitor CAS# 891494-64-7 |
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Quality Control & MSDS
3D structure
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| Cas No. | 891494-64-7 | SDF | Download SDF |
| PubChem ID | 46239014 | Appearance | Powder |
| Formula | C15H18BrN7 | M.Wt | 376.25 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | MK-8776 S-isomer | ||
| Solubility | DMSO : ≥ 100 mg/mL (265.78 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 6-bromo-3-(1-methylpyrazol-4-yl)-5-[(3S)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidin-7-amine | ||
| SMILES | CN1C=C(C=N1)C2=C3N=C(C(=C(N3N=C2)N)Br)C4CCCNC4 | ||
| Standard InChIKey | GMIZZEXBPRLVIV-VIFPVBQESA-N | ||
| Standard InChI | InChI=1S/C15H18BrN7/c1-22-8-10(6-19-22)11-7-20-23-14(17)12(16)13(21-15(11)23)9-3-2-4-18-5-9/h6-9,18H,2-5,17H2,1H3/t9-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | SCH900776 S-isomer is the S-isomer of SCH900776. SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with IC50 of 3 nM. |
SCH900776 S-isomer Dilution Calculator
SCH900776 S-isomer Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6578 mL | 13.289 mL | 26.5781 mL | 53.1561 mL | 66.4452 mL |
| 5 mM | 0.5316 mL | 2.6578 mL | 5.3156 mL | 10.6312 mL | 13.289 mL |
| 10 mM | 0.2658 mL | 1.3289 mL | 2.6578 mL | 5.3156 mL | 6.6445 mL |
| 50 mM | 0.0532 mL | 0.2658 mL | 0.5316 mL | 1.0631 mL | 1.3289 mL |
| 100 mM | 0.0266 mL | 0.1329 mL | 0.2658 mL | 0.5316 mL | 0.6645 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50 = 3 nM), highly selective against Chk2 (IC50 = 1500 nM) and cyclin-dependent kinase CDK2 (IC50 = 160 nM). SCH900776 exposure phenocopies short interfering RNA-mediated CHK1 ablation and interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce dsDNA breaks and cell death in tumor cell backgrounds. Chk1 inhibitor SCH 900776 abrogates cytarabine-induced S-phase arrest and enhances cytarabine cytotoxicity in acute leukemia cell lines and leukemic blasts in vitro.
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SCH900776 S-isomer is the S-isomer of SCH900776. SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with IC50 of 3 nM.
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