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Amicarbalide

CAS# 3459-96-9

Amicarbalide

Catalog No. BCC8117----Order now to get a substantial discount!

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Chemical structure

Amicarbalide

3D structure

Chemical Properties of Amicarbalide

Cas No. 3459-96-9 SDF Download SDF
PubChem ID 72074 Appearance Powder
Formula C15H16N6O M.Wt 296.3
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1,3-bis(3-carbamimidoylphenyl)urea
SMILES C1=CC(=CC(=C1)NC(=O)NC2=CC=CC(=C2)C(=N)N)C(=N)N
Standard InChIKey KRUVSRGJKCHYMY-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H16N6O/c16-13(17)9-3-1-5-11(7-9)20-15(22)21-12-6-2-4-10(8-12)14(18)19/h1-8H,(H3,16,17)(H3,18,19)(H2,20,21,22)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Amicarbalide Dilution Calculator

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Amicarbalide Molarity Calculator

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Preparing Stock Solutions of Amicarbalide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.375 mL 16.8748 mL 33.7496 mL 67.4992 mL 84.3739 mL
5 mM 0.675 mL 3.375 mL 6.7499 mL 13.4998 mL 16.8748 mL
10 mM 0.3375 mL 1.6875 mL 3.375 mL 6.7499 mL 8.4374 mL
50 mM 0.0675 mL 0.3375 mL 0.675 mL 1.35 mL 1.6875 mL
100 mM 0.0337 mL 0.1687 mL 0.3375 mL 0.675 mL 0.8437 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Amicarbalide

Routine screening for potential babesicides using cultures of Babesia bovis.[Pubmed:2242963]

Int J Parasitol. 1990 Oct;20(6):797-802.

A procedure for screening of potential anti-malarial agents, based on the incorporation of [3H]hypoxanthine by the parasite, was adapted for the testing of anti-metabolites against Babesia bovis (Lismore and Samford isolates) cultured in vitro. A close correlation was found between [3H]hypoxanthine incorporation in a standard assay and percentage of parasitized cells as determined by microscopic examination. The concentrations of compounds causing 50% inhibition of [3H]hypoxanthine incorporation (ID50 values) for the established babesicides, Imidocarb and Amicarbalide, were determined to be 3 ng ml-1 (8.6 nM) and 5-10 ng ml-1 (17-34 nM), respectively. A variety of other anti-metabolites were tested in the system. ID50 values for some of the more effective compounds were tubercidin (75 nM), tetracycline (25 microM), menoctone (100 nM) and TN 108, a di-Mannich base derived from 4-(7'-trifluoromethyl-quinolin-4'-ylamino)phenol (0.13 microM). No significant differences between results with the two isolates of B. bovis were observed.

Putrescine uptake inhibition by aromatic diamidines in Leishmania infantum promastigotes.[Pubmed:8204103]

Biochem Pharmacol. 1994 May 18;47(10):1859-66.

The effect of a series of aromatic diamidines has been tested on Leishmania infantum promastigotes in both culture growth and putrescine uptake. The EC50 values calculated by means of dose-response curves were 45, 80, 165, 259 and 600 microM for 4', 6-diamidino-2-phenylindole (DAPI), dibromo propamidine, pentamidine 2-hydroxy stilbamidine and stilbamidine, respectively, although no inhibitory effects on cell growth were found at 1 mM propamidine, phenamidine and Amicarbalide. When these compounds were kinetically analysed for putrescine uptake using Lineweaver-Burk plots, the Ki values reached were: DAPI, 15 microM; pentamidine, 3 microM; dibromo propamidine, 7 microM; 2-hydroxy stilbamidine, 21 microM; stilbamidine, 20 microM; propamidine, 25 microM; and phenamidine, 95 microM. Amicarbalide, however, was not able to reduce putrescine uptake to a significant extent, even at the highest concentration studied of 1 mM.

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