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Dehydrodeguelin

CAS# 3466-23-7

Dehydrodeguelin

2D Structure

Catalog No. BCN4778----Order now to get a substantial discount!

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Quality Control of Dehydrodeguelin

3D structure

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Dehydrodeguelin

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Chemical Properties of Dehydrodeguelin

Cas No. 3466-23-7 SDF Download SDF
PubChem ID 3083803 Appearance Powder
Formula C23H20O6 M.Wt 392.4
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1(C=CC2=C(O1)C=CC3=C2OC4=C(C3=O)C5=CC(=C(C=C5OC4)OC)OC)C
Standard InChIKey NGQVFILFHVPLFE-UHFFFAOYSA-N
Standard InChI InChI=1S/C23H20O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10H,11H2,1-4H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Dehydrodeguelin

The herbs of Derris robusta

Biological Activity of Dehydrodeguelin

DescriptionStandard reference
In vitro

Rotenoids from Lablab purpureus L. and their bioefficacy against human disease vectors.[Pubmed: 20803155]

Parasitol Res. 2010 Nov;107(6):1481-8.

Various plant parts of Lablab purpureu s L. were collected and analyzed separately for their rotenoid content.
METHODS AND RESULTS:
Among the plant parts, the maximum content was in the roots and minimum in the seeds. The identity of different rotenoids was confirmed by melting point, mixed melting point, UV, and infrared spectral studies and gas-liquid chromatography. Six rotenoids (deguelin, Dehydrodeguelin, rotenol, rotenone, tephrosin, and sumatrol) were isolated, identified, and quantified both in vivo and in vitro.
CONCLUSIONS:
Toxicological studies of extracts showed bioefficacy against causal agents of malaria, dracunculiasis, and amoebiasis.

Protocol of Dehydrodeguelin

Structure Identification
Nat Prod Commun. 2012 Oct;7(10):1305-7.

Two new flavonoids from the seeds of Derris scandens.[Pubmed: 23156994]


METHODS AND RESULTS:
Two new flavonoids, (2S)-3',4',5'-trimethoxyflavanone (1) and 2'-hydroxy-2,4-dimethoxy-4'-O-[(E)-3,7-dimethyl-2,6-octadienyl]chalcone (2), together with a known pterocarpene, flemichapparin B (3), and a known rotenoid, Dehydrodeguelin (4), were isolated from the seeds of Derris scandens.
CONCLUSIONS:
Their structures were determined by means of extensive 1D and 2D NMR spectral studies.

Phytochemistry. 2008 Jan;69(1):258-63.

Rotenoid derivatives and other constituents of the twigs of Millettia duchesnei.[Pubmed: 17640692]


METHODS AND RESULTS:
Three prenylated rotenoids, elliptol, 12-deoxo-12alpha-methoxyelliptone and 6-methoxy-6a,12a-Dehydrodeguelin were isolated from the twigs of Millettia duchesnei, together with the known compounds, 6a,12a-Dehydrodeguelin, 6-hydroxy-6a,12a-Dehydrodeguelin, 6-oxo-6a,12a-Dehydrodeguelin, elliptone, 12a-hydroxyelliptone and eriodictyol. Their structures were elucidated on the basis of spectral data and comparison with information reported in the literature and with authentic specimens for some known compounds.
CONCLUSIONS:
The full NMR data of 6-oxo-6a,12a-Dehydrodeguelin and 6-hydroxy-6a,12a-Dehydrodeguelin are reported here for the first time.

Dehydrodeguelin Dilution Calculator

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Dehydrodeguelin Molarity Calculator

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Preparing Stock Solutions of Dehydrodeguelin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5484 mL 12.7421 mL 25.4842 mL 50.9684 mL 63.7105 mL
5 mM 0.5097 mL 2.5484 mL 5.0968 mL 10.1937 mL 12.7421 mL
10 mM 0.2548 mL 1.2742 mL 2.5484 mL 5.0968 mL 6.371 mL
50 mM 0.051 mL 0.2548 mL 0.5097 mL 1.0194 mL 1.2742 mL
100 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.5097 mL 0.6371 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Dehydrodeguelin

Rotenoid derivatives and other constituents of the twigs of Millettia duchesnei.[Pubmed:17640692]

Phytochemistry. 2008 Jan;69(1):258-63.

Three prenylated rotenoids, elliptol, 12-deoxo-12alpha-methoxyelliptone and 6-methoxy-6a,12a-Dehydrodeguelin were isolated from the twigs of Millettia duchesnei, together with the known compounds, 6a,12a-Dehydrodeguelin, 6-hydroxy-6a,12a-Dehydrodeguelin, 6-oxo-6a,12a-Dehydrodeguelin, elliptone, 12a-hydroxyelliptone and eriodictyol. Their structures were elucidated on the basis of spectral data and comparison with information reported in the literature and with authentic specimens for some known compounds. The full NMR data of 6-oxo-6a,12a-Dehydrodeguelin and 6-hydroxy-6a,12a-Dehydrodeguelin are reported here for the first time.

Two new flavonoids from the seeds of Derris scandens.[Pubmed:23156994]

Nat Prod Commun. 2012 Oct;7(10):1305-7.

Two new flavonoids, (2S)-3',4',5'-trimethoxyflavanone (1) and 2'-hydroxy-2,4-dimethoxy-4'-O-[(E)-3,7-dimethyl-2,6-octadienyl]chalcone (2), together with a known pterocarpene, flemichapparin B (3), and a known rotenoid, Dehydrodeguelin (4), were isolated from the seeds of Derris scandens. Their structures were determined by means of extensive 1D and 2D NMR spectral studies.

Rotenoids from Lablab purpureus L. and their bioefficacy against human disease vectors.[Pubmed:20803155]

Parasitol Res. 2010 Nov;107(6):1481-8.

Various plant parts of Lablab purpureu s L. were collected and analyzed separately for their rotenoid content. Among the plant parts, the maximum content was in the roots and minimum in the seeds. The identity of different rotenoids was confirmed by melting point, mixed melting point, UV, and infrared spectral studies and gas-liquid chromatography. Six rotenoids (deguelin, Dehydrodeguelin, rotenol, rotenone, tephrosin, and sumatrol) were isolated, identified, and quantified both in vivo and in vitro. Toxicological studies of extracts showed bioefficacy against causal agents of malaria, dracunculiasis, and amoebiasis.

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