Anemosapogenin

CAS# 85999-40-2

Anemosapogenin

Catalog No. BCN2454----Order now to get a substantial discount!

Product Name & Size Price Stock
Anemosapogenin: 5mg $92 In Stock
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Quality Control of Anemosapogenin

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Chemical structure

Anemosapogenin

3D structure

Chemical Properties of Anemosapogenin

Cas No. 85999-40-2 SDF Download SDF
PubChem ID 21672692 Appearance White powder
Formula C30H48O4 M.Wt 472.71
Type of Compound Triterpenoids Storage Desiccate at -20°C
Synonyms Anemosapogenin
Solubility Soluble in DMSO and methan
Chemical Name (1R,3aS,5aR,5bR,7aR,8R,9S,11aR,11bR,13aR,13bR)-9-hydroxy-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid
SMILES CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)CO)O)C)C(=O)O
Standard InChIKey HXWLKAXCQLXHML-WGOZWDAUSA-N
Standard InChI InChI=1S/C30H48O4/c1-18(2)19-9-14-30(25(33)34)16-15-28(5)20(24(19)30)7-8-22-26(3)12-11-23(32)27(4,17-31)21(26)10-13-29(22,28)6/h19-24,31-32H,1,7-17H2,2-6H3,(H,33,34)/t19-,20+,21+,22+,23-,24+,26-,27-,28+,29+,30-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Anemosapogenin

1 Paeonia sp. 2 Pulsatilla sp. 3 Rourea sp.

Biological Activity of Anemosapogenin

DescriptionAnemosapogenin shows potent anti-tumor effect in vivo, but it has some toxicity, structure modification should be needed.
In vivo

The anti-tumor effect of the extract from Radix Pulsatillae[Reference: WebLink]

Chinese Journal of Hospital Pharmacy, 2003 , 23 (9) :532-3.

To extract Anemosapogenin from Radix Pulsatillae and study its anti tumor activity.
METHODS AND RESULTS:
Total saponins were isolated from Radix Pulsatillae , then hydrolyze into sapogenins , the sapogenins were purified by column chromatography. The furified substance was mixed with vegetable oil as suspension of different concentrations. Mice with transplantable tumors(HepA liver carcinoma, Ehrlich ascites cancer)were administrated continuously for ten days by i.p. with different dosages according to the mice weight. The anti tumor effect in vivo and the rate of life elongation of the mice was observed. Low concentration group and middle concentration group had obvious effect on inhibiting the growth of HepA liver carcinoma in vivo, but the high concentration group had little effect . However, the life elongation effect was not obvious.
CONCLUSIONS:
The extract from Radix Pulsatillael (3β,23 dihydroxyl

Anemosapogenin Dilution Calculator

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Anemosapogenin Molarity Calculator

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Preparing Stock Solutions of Anemosapogenin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1155 mL 10.5773 mL 21.1546 mL 42.3092 mL 52.8865 mL
5 mM 0.4231 mL 2.1155 mL 4.2309 mL 8.4618 mL 10.5773 mL
10 mM 0.2115 mL 1.0577 mL 2.1155 mL 4.2309 mL 5.2887 mL
50 mM 0.0423 mL 0.2115 mL 0.4231 mL 0.8462 mL 1.0577 mL
100 mM 0.0212 mL 0.1058 mL 0.2115 mL 0.4231 mL 0.5289 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Anemosapogenin

23-hydroxybetulinic acid is one of the bioactive components responsible for its anticancer activity. In vitro: 23-hydroxybetulinic acid also shows different proliferation inhibitory activity against B16, HeLa, and HUVEC, with the IC50 value of 78.5, 80, and 94.8 uM, respectively. 23-hydroxybetulinic acid can promote cell cycle arrest at S phase and induce apoptosis via intrinsic pathway. 23-hydroxybetulinic acid disrupts mitochondrial membrane potential significantly (p<0.01) and selectively downregulates the levels of Bcl-2, survivin and upregulates Bax, cytochrome C, cleaved caspase-9 23-hydroxybetulinic acid can induce apoptosis in K562 cells. [1] 23-hydroxybetulinic acid enhances sensitivity of doxorubicin (DOX, ADR) on MCF-7/ADR cell lines, indicating its potential to be developed as a novel MDR modulator.[2] 23-HBA significantly improve the sensitivity of the tumor to doxorubicin. [3]

References:
[1]. Liu M et al. Cytotoxicity of the compounds isolated from Pulsatilla chinensis saponins and apoptosis induced by 23-hydroxybetulinic acid. Pharm Biol. 2015 Jan;53(1):1-9. [2]. Zhang DM et al. BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo. Mol Pharm. 2012 Nov 5;9(11):3147-59. [3]. Zheng Y et al. 23-Hydroxybetulinic acid from Pulsatilla chinensis (Bunge) Regel synergizes the antitumor activities of doxorubicin in vitro and in vivo. J Ethnopharmacol. 2010 Apr 21;128(3):615-22.

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Description

23-hydroxybetulinic acid is one of the bioactive components responsible for its anticancer activity.

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