Lincomycin hydrochlorideCAS# 859-18-7 |
Quality Control & MSDS
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| Cas No. | 859-18-7 | SDF | Download SDF |
| PubChem ID | 45357514 | Appearance | Powder |
| Formula | C18H35ClN2O6S | M.Wt | 443 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | U10149A | ||
| Solubility | Soluble in DMSO > 10 mM | ||
| Chemical Name | (2S,4R)-N-[2-hydroxy-1-[(3R,4R,5S)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride | ||
| SMILES | CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O.Cl | ||
| Standard InChIKey | POUMFISTNHIPTI-FDZUOWKVSA-N | ||
| Standard InChI | InChI=1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9?,10-,11+,12?,13-,14-,15+,16?,18?;/m1./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Lincomycin hydrochloride Dilution Calculator
Lincomycin hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2573 mL | 11.2867 mL | 22.5734 mL | 45.1467 mL | 56.4334 mL |
| 5 mM | 0.4515 mL | 2.2573 mL | 4.5147 mL | 9.0293 mL | 11.2867 mL |
| 10 mM | 0.2257 mL | 1.1287 mL | 2.2573 mL | 4.5147 mL | 5.6433 mL |
| 50 mM | 0.0451 mL | 0.2257 mL | 0.4515 mL | 0.9029 mL | 1.1287 mL |
| 100 mM | 0.0226 mL | 0.1129 mL | 0.2257 mL | 0.4515 mL | 0.5643 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Lincomycin Hydrochloride(U10149A) is an antibiotic produced by Streptomyces lincolnensis var. lincolnensis. Target: Antibacterial Lincomycin hydrochloride is a systemic antibiotic, which is active against most common gram positive bacteria. It has proved to be excellent for infectious diseases like acne, anthrax, pneumonia, and also for the treatment of furunculosis, carbuncles, impetigo, burns and wounds, carrying to gram positive bacteria. Lincomycin hydrochloride inhibits cell growth and microbial protein synthesis, by interacting strongly and specifically with the 50S ribosomal subunit, at mutually related sites [1-3].
References:
[1]. Griaznova, N.S., et al., [Effect of lincomycin and other protein synthesis inhibitors on the metabolism of Actinomyces roseolus, a producer of lincomycin]. Antibiotiki, 1980. 25(4): p. 250-6.
[2]. Hummel, H., W. Piepersberg, and A. Bock, Analysis of lincomycin resistance mutations in Escherichia coli. Mol Gen Genet, 1979. 169(3): p. 345-7.
[3]. Champney, W.S. and C.L. Tober, Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics. Curr Microbiol, 2000. 41(2): p. 126-35.
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Lincomycin Hydrochloride(U10149A) is an antibiotic produced by Streptomyces lincolnensis var.
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