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11,12-Di-O-acetyltenacigenin B

CAS# 857897-01-9

11,12-Di-O-acetyltenacigenin B

Catalog No. BCN4565----Order now to get a substantial discount!

Product Name & Size Price Stock
11,12-Di-O-acetyltenacigenin B: 5mg $886 In Stock
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Quality Control of 11,12-Di-O-acetyltenacigenin B

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Chemical structure

11,12-Di-O-acetyltenacigenin B

3D structure

Chemical Properties of 11,12-Di-O-acetyltenacigenin B

Cas No. 857897-01-9 SDF Download SDF
PubChem ID 91886693 Appearance Powder
Formula C25H36O7 M.Wt 448.56
Type of Compound Steroids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC(=O)C1CCC23C1(C(C(C4C2(O3)CCC5C4(CCC(C5)O)C)OC(=O)C)OC(=O)C)C
Standard InChIKey MIGQPMYRGFABCC-BIWLUZBDSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 11,12-Di-O-acetyltenacigenin B

The herbs of Marsdenia tenacissima

11,12-Di-O-acetyltenacigenin B Dilution Calculator

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11,12-Di-O-acetyltenacigenin B Molarity Calculator

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Preparing Stock Solutions of 11,12-Di-O-acetyltenacigenin B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2294 mL 11.1468 mL 22.2936 mL 44.5871 mL 55.7339 mL
5 mM 0.4459 mL 2.2294 mL 4.4587 mL 8.9174 mL 11.1468 mL
10 mM 0.2229 mL 1.1147 mL 2.2294 mL 4.4587 mL 5.5734 mL
50 mM 0.0446 mL 0.2229 mL 0.4459 mL 0.8917 mL 1.1147 mL
100 mM 0.0223 mL 0.1115 mL 0.2229 mL 0.4459 mL 0.5573 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 11,12-Di-O-acetyltenacigenin B

Citrinal B, natural 11 beta-hydroxysteroid dehydrogennase type 1 inhibitor identified from structure-based virtual screening.[Pubmed:28962943]

Fitoterapia. 2017 Nov;123:29-34.

Citrinal B, a tricyclic compound from endophytic fungus Colletotrichum capsici in our previous studies, exhibited significant inhibitory activity against 11beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) in vitro and showed strong binding affinity to 11beta-HSD1. Moreover, citrinal B treatments decreased the lipid droplet accumulation associate with the inhibition of 11beta-HSD1 expression in differentiate induced 3T3-L1 preadipocytes. Furthermore, the molecular docking demonstrated that citrinal B coordinated in the active site of 11beta-HSD1 is essential for the ability of diminishing the enzyme activity.

Synthesis and biological evaluation of novel 6,11-dihydro-5H-benzo[e]pyrimido- [5,4-b][1,4]diazepine derivatives as potential c-Met inhibitors.[Pubmed:28938137]

Eur J Med Chem. 2017 Nov 10;140:212-228.

Over expression of c-Met tyrosine kinase is known to promote tumorigenesis and metastasis, as well as to cause therapeutic resistance. Herein a series of novel 6,11-dihydro-5H-benzo[e]pyrimido[5,4-b][1,4]diazepine derivatives were designed, synthesised and evaluated for their c-Met kinase inhibition. Compounds 17e, 17f, 18a, and 18b were further examined for their anti-proliferative activities against four typical cancer cell lines (PC-3, Panc-1, HepG2, and Caki-1). The promising compound 17f was identified as a multi-target receptor tyrosine kinase inhibitor, which also displayed favourable pharmacokinetic properties in rats, had an acceptable safety profile in preclinical studies, and significant anti-tumour activity in the Caki-1 tumour xenograft model.

LncRNA ZEB1-AS1 contributes to STAT3 activation by associating with IL-11 in B-lymphoblastic leukemia.[Pubmed:28861713]

Biotechnol Lett. 2017 Dec;39(12):1801-1810.

OBJECTIVE: To investigate the role of lncRNA ZEB1-AS1 in B-lineage acute lymphoblastic leukemia (B-ALL). RESULTS: ZEB1-AS1 levels were aberrantly up-regulated in B-ALL. All correlated with STAT3 activation and IL-11 production. Moreover, a high level of ZEB1-AS1 predicted poor prognosis of B-ALL patients. Mechanistically, ZEB1-AS1 could bind to IL-11 and promote IL-11 stability. Down-regulation of ZEB1-AS1 decreased IL-11 production of human bone marrow stromal cells (BMSCs), which led to suppressed proliferation and inhibited IL-11/STAT3 pathway in BALL-1 cells. CONCLUSIONS: ZEB1-AS1 promotes the activation of IL-11/STAT3 signaling pathway by associating with IL-11 in B-ALL.

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