Antibiotic ZG 1494alphaCAS# 182320-33-8 |
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| Cas No. | 182320-33-8 | SDF | Download SDF |
| PubChem ID | 101999305 | Appearance | Powder |
| Formula | C32H43NO4 | M.Wt | 505.70 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3-[(1S,2R,4aR,6R,8aS)-3,4a,6-trimethyl-2-[(E)-4-methylhex-2-en-2-yl]-2,5,6,7,8,8a-hexahydro-1H-naphthalene-1-carbonyl]-5-hydroxy-5-[(4-hydroxyphenyl)methyl]-1H-pyrrol-2-one | ||
| SMILES | CCC(C)C=C(C)C1C(C2CCC(CC2(C=C1C)C)C)C(=O)C3=CC(NC3=O)(CC4=CC=C(C=C4)O)O | ||
| Standard InChIKey | DZMMOKIPXHQOJN-NNYKWDJVSA-N | ||
| Standard InChI | InChI=1S/C32H43NO4/c1-7-19(2)14-21(4)27-22(5)16-31(6)15-20(3)8-13-26(31)28(27)29(35)25-18-32(37,33-30(25)36)17-23-9-11-24(34)12-10-23/h9-12,14,16,18-20,26-28,34,37H,7-8,13,15,17H2,1-6H3,(H,33,36)/b21-14+/t19?,20-,26+,27-,28+,31+,32?/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The Sclerophoma pythiophila
| Description | 1. Antibiotic ZG 1494alpha is a novel inhibitor of platelet-activating factor (PAF) acetyltransferase. 2. Antibiotic ZG-1494alpha exhibits antifungal activity against Candida albicans. |
| Targets | PAFR | Antifection |
Antibiotic ZG 1494alpha Dilution Calculator
Antibiotic ZG 1494alpha Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9775 mL | 9.8873 mL | 19.7746 mL | 39.5491 mL | 49.4364 mL |
| 5 mM | 0.3955 mL | 1.9775 mL | 3.9549 mL | 7.9098 mL | 9.8873 mL |
| 10 mM | 0.1977 mL | 0.9887 mL | 1.9775 mL | 3.9549 mL | 4.9436 mL |
| 50 mM | 0.0395 mL | 0.1977 mL | 0.3955 mL | 0.791 mL | 0.9887 mL |
| 100 mM | 0.0198 mL | 0.0989 mL | 0.1977 mL | 0.3955 mL | 0.4944 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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ZG-1494 alpha, a novel platelet-activating factor acetyltransferase inhibitor from Penicillium rubrum, isolation, structure elucidation andbiological activity.[Pubmed:8968388]
J Antibiot (Tokyo). 1996 Oct;49(10):967-73.
A novel inhibitor of platelet-activating factor (PAF) acetyltransferase, an essential enzyme in the remodeling pathway of platelet-activating factor synthesis, was identified by a high throughout screen of natural product extracts of microbial origin. The compound, ZG-1494 alpha, was isolated from an ethyl acetate extract of a culture broth of Penicillium rubrum through bioassay guided fractionation. The structure of ZG-1494 alpha was determined by spectroscopic methods. A key feature of the structure, which is relatively rare among natural products, is the 5-hydroxy-3-pyrrolin-2-one moiety. A 13C-13C INADEQUATE was utilized to unambiguously determine the regiochemistry of this molecule.
Antifungal substances against pathogenic fungi, talaroconvolutins, from talaromyces convolutus.[Pubmed:10869198]
J Nat Prod. 2000 Jun;63(6):768-72.
The dichloromethane extract of Talaromyces convolutus cultivated on barley exhibited antifungal activity against Candida albicans. In the course of a search for the active compounds, four new tetramic acid derivatives, talaroconvolutins A (1), B (2), C (3), and D (4), were isolated along with ZG-1494alpha (5), and mitorubrin derivatives. The structures of talaroconvolutins A-D (1-4) were established on the basis of spectroscopic and chemical investigations and chemical correlations. The antifungal activity of the talaroconvolutins against the pathogenic fungi Aspergillus fumigates, Aspergillus niger, C. albicans, and Cryptococcus neoformans was determined.
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