Oteromycin

CAS# 170591-45-4

Oteromycin

Catalog No. BCN1849----Order now to get a substantial discount!

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Oteromycin: 5mg Please Inquire In Stock
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Quality Control of Oteromycin

Number of papers citing our products

Chemical structure

Oteromycin

3D structure

Chemical Properties of Oteromycin

Cas No. 170591-45-4 SDF Download SDF
PubChem ID 6436254 Appearance Powder
Formula C32H41NO3 M.Wt 487.68
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-[3,4a,6-trimethyl-2-[(2E,4E)-4-methylhexa-2,4-dien-2-yl]-2,5,6,7,8,8a-hexahydro-1H-naphthalene-1-carbonyl]-5-benzyl-5-hydroxy-1H-pyrrol-2-one
SMILES CC=C(C)C=C(C)C1C(C2CCC(CC2(C=C1C)C)C)C(=O)C3=CC(NC3=O)(CC4=CC=CC=C4)O
Standard InChIKey LERBUEGMFSDFOI-HNRJQCQOSA-N
Standard InChI InChI=1S/C32H41NO3/c1-7-20(2)15-22(4)27-23(5)17-31(6)16-21(3)13-14-26(31)28(27)29(34)25-19-32(36,33-30(25)35)18-24-11-9-8-10-12-24/h7-12,15,17,19,21,26-28,36H,13-14,16,18H2,1-6H3,(H,33,35)/b20-7+,22-15+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Oteromycin

Description1. Oteromycin is a inhibitor of HIV-1 integrase.
TargetsHIV

Oteromycin Dilution Calculator

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Oteromycin Molarity Calculator

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Preparing Stock Solutions of Oteromycin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0505 mL 10.2526 mL 20.5052 mL 41.0105 mL 51.2631 mL
5 mM 0.4101 mL 2.0505 mL 4.101 mL 8.2021 mL 10.2526 mL
10 mM 0.2051 mL 1.0253 mL 2.0505 mL 4.101 mL 5.1263 mL
50 mM 0.041 mL 0.2051 mL 0.4101 mL 0.8202 mL 1.0253 mL
100 mM 0.0205 mL 0.1025 mL 0.2051 mL 0.4101 mL 0.5126 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Oteromycin

Isolation and characterization of novel human immunodeficiency virus integrase inhibitors from fungal metabolites.[Pubmed:10335400]

Antivir Chem Chemother. 1999 Mar;10(2):63-70.

We have identified a series of novel inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase by randomly screening natural product extracts using an in vitro biochemical assay designed to identify inhibitors of integrase-catalysed strand transfer. Equisetin recovered from the fungus Fusarium heterosporum and a novel enantiomeric homologue of equisetin from Phoma sp. were isolated as inhibitors of HIV-1 integrase in vitro. Two additional analogues, a novel decalin derivative, integric acid, and Oteromycin were also discovered to be inhibitors of integrase. Equisetin and related compounds inhibit 3' end-processing and strand transfer as well as disintegration catalysed by either the full-length enzyme or the truncated integrase core domain (amino acids 50-212). These compounds also inhibit strand transfer reactions catalysed by stable complexes assembled in vitro and integration reactions catalysed by pre-integration complexes isolated from HIV-1-infected cells. The compounds described in this report are structurally novel and mechanistically distinct from many previously described inhibitors of HIV-1 integrase. These results demonstrate the utility of using an appropriately configured assay to identify compounds that are effective post-assembly and the potential of isolating novel integrase inhibitors from complex natural product extracts.

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