OteromycinCAS# 170591-45-4 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 170591-45-4 | SDF | Download SDF |
| PubChem ID | 6436254 | Appearance | Powder |
| Formula | C32H41NO3 | M.Wt | 487.68 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3-[3,4a,6-trimethyl-2-[(2E,4E)-4-methylhexa-2,4-dien-2-yl]-2,5,6,7,8,8a-hexahydro-1H-naphthalene-1-carbonyl]-5-benzyl-5-hydroxy-1H-pyrrol-2-one | ||
| SMILES | CC=C(C)C=C(C)C1C(C2CCC(CC2(C=C1C)C)C)C(=O)C3=CC(NC3=O)(CC4=CC=CC=C4)O | ||
| Standard InChIKey | LERBUEGMFSDFOI-HNRJQCQOSA-N | ||
| Standard InChI | InChI=1S/C32H41NO3/c1-7-20(2)15-22(4)27-23(5)17-31(6)16-21(3)13-14-26(31)28(27)29(34)25-19-32(36,33-30(25)35)18-24-11-9-8-10-12-24/h7-12,15,17,19,21,26-28,36H,13-14,16,18H2,1-6H3,(H,33,35)/b20-7+,22-15+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Oteromycin is a inhibitor of HIV-1 integrase. |
| Targets | HIV |
Oteromycin Dilution Calculator
Oteromycin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.0505 mL | 10.2526 mL | 20.5052 mL | 41.0105 mL | 51.2631 mL |
| 5 mM | 0.4101 mL | 2.0505 mL | 4.101 mL | 8.2021 mL | 10.2526 mL |
| 10 mM | 0.2051 mL | 1.0253 mL | 2.0505 mL | 4.101 mL | 5.1263 mL |
| 50 mM | 0.041 mL | 0.2051 mL | 0.4101 mL | 0.8202 mL | 1.0253 mL |
| 100 mM | 0.0205 mL | 0.1025 mL | 0.2051 mL | 0.4101 mL | 0.5126 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- SC 236
Catalog No.:BCC7809
CAS No.:170569-86-5
- Isohyperectine
Catalog No.:BCN3405
CAS No.:170384-75-5
- 1,4-Epidioxybisabola-2,10-dien-9-one
Catalog No.:BCN7532
CAS No.:170380-69-5
- 4-(6-Methyl-4-oxohept-5-en-2-yl)cyclohex-2-en-1-one
Catalog No.:BCN7528
CAS No.:170380-68-4
- Enzastaurin (LY317615)
Catalog No.:BCC1100
CAS No.:170364-57-5
- CD 2665
Catalog No.:BCC7778
CAS No.:170355-78-9
- CD 2314
Catalog No.:BCC6071
CAS No.:170355-37-0
- 24-Methylenecycloartane-3beta,26-diol
Catalog No.:BCN1530
CAS No.:17020-27-8
- Bauerenol acetate
Catalog No.:BCN1106
CAS No.:17020-04-1
- 11-Keto-beta-boswellic acid
Catalog No.:BCN2298
CAS No.:17019-92-0
- Nepicastat (SYN-117) HCl
Catalog No.:BCC2286
CAS No.:170151-24-3
- Curcolone
Catalog No.:BCN3559
CAS No.:17015-43-9
- YC 1
Catalog No.:BCC7912
CAS No.:170632-47-0
- Fmoc-D-Abu-OH
Catalog No.:BCC3203
CAS No.:170642-27-0
- α-Conotoxin EI
Catalog No.:BCC5979
CAS No.:170663-33-9
- D-Mannitol diacetonide
Catalog No.:BCC8951
CAS No.:1707-77-3
- Bindone
Catalog No.:BCC8877
CAS No.:1707-95-5
- 6beta-Hydroxyhispanone
Catalog No.:BCN7453
CAS No.:170711-93-0
- Nociceptin
Catalog No.:BCC5686
CAS No.:170713-75-4
- 11-Deoxymogroside V
Catalog No.:BCN8143
CAS No.:1707161-17-8
- Aprepitant
Catalog No.:BCC1101
CAS No.:170729-80-3
- Trityl candesartan cilexetil
Catalog No.:BCC9188
CAS No.:170791-09-0
- Astressin
Catalog No.:BCC5790
CAS No.:170809-51-5
- CHPG
Catalog No.:BCC6910
CAS No.:170846-74-9
Isolation and characterization of novel human immunodeficiency virus integrase inhibitors from fungal metabolites.[Pubmed:10335400]
Antivir Chem Chemother. 1999 Mar;10(2):63-70.
We have identified a series of novel inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase by randomly screening natural product extracts using an in vitro biochemical assay designed to identify inhibitors of integrase-catalysed strand transfer. Equisetin recovered from the fungus Fusarium heterosporum and a novel enantiomeric homologue of equisetin from Phoma sp. were isolated as inhibitors of HIV-1 integrase in vitro. Two additional analogues, a novel decalin derivative, integric acid, and Oteromycin were also discovered to be inhibitors of integrase. Equisetin and related compounds inhibit 3' end-processing and strand transfer as well as disintegration catalysed by either the full-length enzyme or the truncated integrase core domain (amino acids 50-212). These compounds also inhibit strand transfer reactions catalysed by stable complexes assembled in vitro and integration reactions catalysed by pre-integration complexes isolated from HIV-1-infected cells. The compounds described in this report are structurally novel and mechanistically distinct from many previously described inhibitors of HIV-1 integrase. These results demonstrate the utility of using an appropriately configured assay to identify compounds that are effective post-assembly and the potential of isolating novel integrase inhibitors from complex natural product extracts.
