BC 11-38

Selective PDE11 inhibitor CAS# 686770-80-9

BC 11-38

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Catalog No. BCC7940----Order now to get a substantial discount!

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BC 11-38

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Chemical Properties of BC 11-38

Cas No. 686770-80-9 SDF Download SDF
PubChem ID 2052828 Appearance Powder
Formula C15H16N2OS2 M.Wt 304.43
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO and to 20 mM in ethanol
Chemical Name 3-phenyl-2-propylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one
SMILES CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2
Standard InChIKey YHNDCCKFNWDQGW-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H16N2OS2/c1-2-9-20-15-16-12-8-10-19-13(12)14(18)17(15)11-6-4-3-5-7-11/h3-7H,2,8-10H2,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of BC 11-38

DescriptionSelective phosphodiesterase (PDE) 11 inhibitor (IC50 = 0.28 μM for PDE11; IC50 values are >100 μM for PDE1 - PDE10). Significantly elevates cAMP levels and cortisol production in H295R human adenocarcinoma cells.

BC 11-38 Dilution Calculator

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BC 11-38 Molarity Calculator

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Preparing Stock Solutions of BC 11-38

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2848 mL 16.4241 mL 32.8483 mL 65.6965 mL 82.1207 mL
5 mM 0.657 mL 3.2848 mL 6.5697 mL 13.1393 mL 16.4241 mL
10 mM 0.3285 mL 1.6424 mL 3.2848 mL 6.5697 mL 8.2121 mL
50 mM 0.0657 mL 0.3285 mL 0.657 mL 1.3139 mL 1.6424 mL
100 mM 0.0328 mL 0.1642 mL 0.3285 mL 0.657 mL 0.8212 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on BC 11-38

BC 11-38 is a selective inhibitor of PDE11 with an IC50 value of 0.28 μM [1].

PDE11 is a PDE family. In humans the PDE11A gene encodes four isoforms hydrolyzing both cAMP and cGMP. PDE11A is expressed in skeletal muscle, brain, prostate, testis, kidney, pancreas, liver, lymphoid cells, and pituitary and adrenal glands [2].

In H295R human adenocarcinoma cells, BC11-38 significantly increased cortisol production and cAMP levels, both in the presence and absence of the adenylate cyclase activator forskolin. In H295R cells, BC11-38 elevated ATF-1 phosphorylation in a manner that corresponded with its potency against PDE11. In several lines including MDA-MB-231 and HeLa cells, there were very low levels of PDE11A mRNA. In MDA-MB-231 cells, BC11-38 failed to elevate cAMP levels and CREB phosphorylation. In HeLa cells, BC11-38 did not affect cAMP levels or CREB phosphorylation [2]. In p54nrb/NONOKD cells, combining treatment with BC11-38 and ACTH restored partially the capacity to produce DHEA and cortisol in response to cAMP stimulation and the ability to generate cAMP in response to ACTH stimulation [3].

An invention also relates to the use of compounds such as BC11-38 to elevate cortisol levels in a subject who has adrenal suppression, e.g. where a subject is being administered with a corticosteroid, or on a long-term corticosteroid treatment [4].

References:
[1].  Cichero E, D'Ursi P, Moscatelli M, et al. Homology modeling, docking studies and molecular dynamic simulations using graphical processing unit architecture to probe the type-11 phosphodiesterase catalytic site: a computational approach for the rational design of selective inhibitors. Chemical biology & drug design, 2013, 82(6): 718-731.
[2].  Ceyhan O, Birsoy K, Hoffman CS. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chemistry & biology, 2012, 19(1): 155-163.
[3].  Lu JY, Sewer MB. p54nrb/NONO Regulates Cyclic AMP-Dependent Glucocorticoid Production by Modulating Phosphodiesterase mRNA Splicing and Degradation. Molecular and cellular biology, 2015, 35(7): 1223-1237.
[4].  Hoffman CS, Ceyhan O. Inhibitors of phosphodiesterase 11 (PDE11): U.S. Patent 9,173,884[P]. 2015-11-3.

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References on BC 11-38

Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen.[Pubmed:22284362]

Chem Biol. 2012 Jan 27;19(1):155-63.

The biological roles of cyclic nucleotide phosphodiesterase 11 (PDE11) enzymes are poorly understood, in part due to the lack of selective inhibitors. To address the need for such compounds, we completed an ~200,000 compound high-throughput screen (HTS) for PDE11 inhibitors using a yeast-based growth assay, and identified 4 potent and selective PDE11 inhibitors. One compound, along with two structural analogs, elevates cAMP and cortisol levels in human adrenocortical cells, consistent with gene association studies that link PDE11 activity to adrenal function. As such, these compounds can immediately serve as chemical tools to study PDE11 function in cell culture, and as leads to develop therapeutics for the treatment of adrenal insufficiencies. Our results further validate this yeast-based HTS platform for the discovery of potent, selective, and biologically active PDE inhibitors.

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