BU 239 hydrochlorideImidazoline receptors-selective antagonist CAS# 1217041-98-9 |
- Risedronate Sodium
Catalog No.:BCC2501
CAS No.:115436-72-1
- Verteporfin
Catalog No.:BCC3690
CAS No.:129497-78-5
- Methylcobalamin
Catalog No.:BCC5188
CAS No.:13422-55-4
- Miglustat hydrochloride
Catalog No.:BCC5186
CAS No.:210110-90-0
- Sulfasalazine
Catalog No.:BCC2545
CAS No.:599-79-1
- SC 144
Catalog No.:BCC1171
CAS No.:895158-95-9
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 1217041-98-9 | SDF | Download SDF |
| PubChem ID | 56846046 | Appearance | Powder |
| Formula | C11H11ClN4 | M.Wt | 234.69 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 50 mM in DMSO | ||
| Chemical Name | 2-(4,5-dihydro-1H-imidazol-2-yl)quinoxaline;hydrochloride | ||
| SMILES | C1CN=C(N1)C2=NC3=CC=CC=C3N=C2.Cl | ||
| Standard InChIKey | NQMMIEICYUXMKP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C11H10N4.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,7H,5-6H2,(H,12,13);1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | High affinity ligand for the imidazoline I2 binding site. |
BU 239 hydrochloride Dilution Calculator
BU 239 hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.2609 mL | 21.3047 mL | 42.6094 mL | 85.2188 mL | 106.5235 mL |
| 5 mM | 0.8522 mL | 4.2609 mL | 8.5219 mL | 17.0438 mL | 21.3047 mL |
| 10 mM | 0.4261 mL | 2.1305 mL | 4.2609 mL | 8.5219 mL | 10.6523 mL |
| 50 mM | 0.0852 mL | 0.4261 mL | 0.8522 mL | 1.7044 mL | 2.1305 mL |
| 100 mM | 0.0426 mL | 0.213 mL | 0.4261 mL | 0.8522 mL | 1.0652 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Target: I1 imidazoline receptor, I2 imidazoline receptor
IC50: 35 nM, 47 nM
BU 239 hydrochloride is an imidazoline receptors-selective antagonist. BU239 displayed high affinity for both I1 imidazoline and I2 imidazoline receptors in competition binding experiments with IC50 values of 35 nM and 47 nM, respectively [1]. The imidazoline receptors involved in circulatory system are classified in two groups: the I1 type and the I2 type. I1 type is sensitive to idazoxan and clonidine, an antagonist with an imidazoline structure. I2 type displays a high affinity for idazoxan, cirazoline, guanabenz and a medium-tolow affinity for clonidine. In particular, Imidazoline I1 receptors play a critical role in the central regulation of blood pressure [2].
In vitro: BU239 (1 μM) reversed α2 agonists-mediated inhibition of arginine vasopressin (AVP)-stimulated water permeability in the rat inner medullary collecting duct (IMCD) [3]. In addition, BU239 significantly reversed agmatine-induced inhibition of AVP-stimulated urea permeability (Pu) in IMCD [4]. BU239 produced positive inotropic activity with the maximum effect observed at 117.4 % [2].
In vivo: N/A
References:
1. Flamez A, De Backer JP, Czerwiec E, Ladure P, Vauquelin G. Pharmacological characterization of I1 and I2 imidazoline receptors in human striatum. Neurochem Int. 1997;30(1):25-9.
2. Radwanska A, Dlugokecka J, Wasilewski R, Kaliszan R. Testing conception of engagement of imidazoline receptors in imidazoline drugs effects on isolated rat heart atria. J Physiol Pharmacol. 2009;60(1):131-42.
3. Kudo LH, Hebert CA, Rouch AJ. Inhibition of water permeability in the rat collecting duct: effect of imidazoline and alpha-2 compounds. Proc Soc Exp Biol Med. 1999;221(2):136-46.
4. Rouch AJ, Kudo LH. Agmatine inhibits arginine vasopressin-stimulated urea transport in the rat inner medullary collecting duct. Kidney Int. 2002;62(6):2101-8.
- PTC209 HBr
Catalog No.:BCC5640
CAS No.:1217022-63-3
- Moluccanin diacetate
Catalog No.:BCN6108
CAS No.:121700-27-4
- Moluccanin
Catalog No.:BCN6107
CAS No.:121700-26-3
- Sarafotoxin S6c
Catalog No.:BCC5721
CAS No.:121695-87-2
- CGP 20712 dihydrochloride
Catalog No.:BCC6893
CAS No.:1216905-73-5
- ZK 93426 hydrochloride
Catalog No.:BCC7229
CAS No.:1216792-30-1
- GSK 4112
Catalog No.:BCC7741
CAS No.:1216744-19-2
- BYK 191023 dihydrochloride
Catalog No.:BCC7506
CAS No.:1216722-25-6
- SCH 79797 dihydrochloride
Catalog No.:BCC7125
CAS No.:1216720-69-2
- Trap 101
Catalog No.:BCC7390
CAS No.:1216621-00-9
- 2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde
Catalog No.:BCC8573
CAS No.:121660-37-5
- 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol
Catalog No.:BCC8574
CAS No.:121660-11-5
- GYKI 47261 dihydrochloride
Catalog No.:BCC7566
CAS No.:1217049-32-5
- 6-O-p-Methoxycinnamoylcatalpol
Catalog No.:BCN6109
CAS No.:121710-02-9
- CP 31398 dihydrochloride
Catalog No.:BCC2406
CAS No.:1217195-61-3
- A 350619 hydrochloride
Catalog No.:BCC5939
CAS No.:1217201-17-6
- VD2-D3
Catalog No.:BCC2034
CAS No.:1217448-46-8
- Ro 26-4550 trifluoroacetate
Catalog No.:BCC5813
CAS No.:1217448-66-2
- Isoderrone
Catalog No.:BCN3698
CAS No.:121747-89-5
- Isochandalone
Catalog No.:BCN4767
CAS No.:121747-90-8
- (+)-UH 232 maleate
Catalog No.:BCC6790
CAS No.:1217473-50-1
- NAS-181
Catalog No.:BCC7056
CAS No.:1217474-40-2
- threo-1-C-Syringylglycerol
Catalog No.:BCN6110
CAS No.:121748-11-6
- BYL-719
Catalog No.:BCC3707
CAS No.:1217486-61-7
