Cernuine

CAS# 6880-84-8

Cernuine

Catalog No. BCN9617----Order now to get a substantial discount!

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Cernuine: 5mg $828 In Stock
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Quality Control of Cernuine

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Chemical structure

Cernuine

3D structure

Chemical Properties of Cernuine

Cas No. 6880-84-8 SDF Download SDF
PubChem ID 442472 Appearance Oil
Formula C16H26N2O M.Wt 262.39
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1S,7S,9R,11S,13S)-11-methyl-2,17-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-3-one
SMILES CC1CC2CCCC3N2C(C1)CC4N3C(=O)CCC4
Standard InChIKey IWSJXTCXZSUCNS-LXFSFDBISA-N
Standard InChI InChI=1S/C16H26N2O/c1-11-8-12-4-2-6-15-17(12)14(9-11)10-13-5-3-7-16(19)18(13)15/h11-15H,2-10H2,1H3/t11-,12-,13-,14+,15-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Cernuine Dilution Calculator

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Cernuine Molarity Calculator

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Preparing Stock Solutions of Cernuine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.8111 mL 19.0556 mL 38.1112 mL 76.2224 mL 95.278 mL
5 mM 0.7622 mL 3.8111 mL 7.6222 mL 15.2445 mL 19.0556 mL
10 mM 0.3811 mL 1.9056 mL 3.8111 mL 7.6222 mL 9.5278 mL
50 mM 0.0762 mL 0.3811 mL 0.7622 mL 1.5244 mL 1.9056 mL
100 mM 0.0381 mL 0.1906 mL 0.3811 mL 0.7622 mL 0.9528 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Cernuine

A neuroinformatics study to compare inhibition efficiency of three natural ligands (Fawcettimine, Cernuine and Lycodine) against human brain acetylcholinesterase.[Pubmed:25611730]

Network. 2015;26(1):25-34.

Enzyme-inhibition is considered as a potent therapeutic approach to the treatment of diseases associated with acetylcholinesterase (AChE). The present study elucidates molecular interactions of human brain AChE, with three natural ligands Lycodine, Cernuine and Fawcettimine for comparison. Docking between these ligands and enzyme was performed using 'Autodock 4.2'. It was determined that polar and hydrophobic interactions play an important role in the correct positioning of Lycodine, Cernuine and Fawcettimine within the 'catalytic site' of AChE to permit docking. This approach would be helpful to understand the selectivity of the given drug molecule in the treatment of neurological disorder. Moreover, the present study confirms that Lycodine is a more efficient inhibitor of human brain AChE compared to Cernuine and Fawcettimine with reference to DeltaG and Ki values.

Lycopodium alkaloids: isolation and asymmetric synthesis.[Pubmed:21452079]

Top Curr Chem. 2012;309:1-31.

Lycopodium alkaloids have attracted the attention of many natural product chemists and synthetic organic chemists due to their important biological activities and unique skeletal characteristics. In this review we describe isolation and asymmetric syntheses of several new alkaloids such as lycoposerramines-C, -V, -W, and Cernuine, and show that asymmetric total synthesis played a key role in elucidating the structures of these complex natural products.

First asymmetric total syntheses of cernuane-type Lycopodium alkaloids, cernuine, and cermizine D.[Pubmed:18429621]

Org Lett. 2008 May 15;10(10):1987-90.

The first total syntheses of two cernuane-type Lycopodium alkaloids, (-)-Cernuine and (+)-cermizine D, were accomplished starting from (+)-citronellal. The syntheses involved organocatalytic alpha-amination to afford oxazolidinone, which is used for diastereoselective allylation, and asymmetric transfer aminoallylation followed by stereoselective construction of an aminal moiety as key steps.

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