5-Methoxyjusticidin ACAS# 205505-62-0 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 205505-62-0 | SDF | Download SDF |
| PubChem ID | 10670001 | Appearance | Powder |
| Formula | C23H20O8 | M.Wt | 424.4 |
| Type of Compound | Lignans | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 9-(1,3-benzodioxol-5-yl)-4,5,6,7-tetramethoxy-3H-benzo[f][2]benzofuran-1-one | ||
| SMILES | COC1=C(C(=C2C(=C1)C(=C3C(=C2OC)COC3=O)C4=CC5=C(C=C4)OCO5)OC)OC | ||
| Standard InChIKey | JZLOANXPTOXARG-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C23H20O8/c1-25-16-8-12-17(11-5-6-14-15(7-11)31-10-30-14)18-13(9-29-23(18)24)20(26-2)19(12)22(28-4)21(16)27-3/h5-8H,9-10H2,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
5-Methoxyjusticidin A Dilution Calculator
5-Methoxyjusticidin A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3563 mL | 11.7813 mL | 23.5627 mL | 47.1254 mL | 58.9067 mL |
| 5 mM | 0.4713 mL | 2.3563 mL | 4.7125 mL | 9.4251 mL | 11.7813 mL |
| 10 mM | 0.2356 mL | 1.1781 mL | 2.3563 mL | 4.7125 mL | 5.8907 mL |
| 50 mM | 0.0471 mL | 0.2356 mL | 0.4713 mL | 0.9425 mL | 1.1781 mL |
| 100 mM | 0.0236 mL | 0.1178 mL | 0.2356 mL | 0.4713 mL | 0.5891 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Protective Roles of Monsonia angustifolia and Its Active Compounds in Experimental Models of Alzheimer's Disease.[Pubmed:28378593]
J Agric Food Chem. 2017 Apr 19;65(15):3133-3140.
Alzheimer's disease (AD), a progressive neurodegenerative disorder, is characterized by the accumulation of neurotoxic beta-amyloid (Abeta) peptides, which consequently affects cognitive decline and memory impairment. Current research on AD treatment is actively focusing on the prevention of neurotoxic Abeta peptide accumulation. Monsonia angustifolia is reported to be consumed as an indigenous vegetable in Tanzania. In this study, we investigated the effect of the ethanol (EtOH) extract of M. angustifolia dried ground material on Abeta production and spatial learning ability as protection against AD. The formation of Abeta peptides was significantly reduced in HeLa cells stably transfected with the Swedish mutant form of beta-amyloid precursor protein (APPsw) after treatment with a 60% EtOH extract of M. angustifolia. We next examined the cognitive-improving effects of the EtOH extract in vivo. Tg2576 mice were treated with extract for 6 months and subjected to Morris water maze and novel object recognition tests. The results showed that the 60% EtOH extract of M. angustifolia significantly ameliorated behavioral deficits of the AD transgenic mice and reduced the level of insoluble Abeta42 in the cerebral cortex and hippocampus. We further found that the 60% EtOH extract was effective for memory function recovery after shorter treatment (4 months). In addition, we isolated and identified several single compounds, justicidin A, 5-Methoxyjusticidin A, chinensinaphthol, retrochinensinaphthol methyl ether, and suchilactone, from M. angustifolia and tested these compounds. Among them, justicidin A potently decreased the formation of Abeta in APPsw-transfected cells. These data suggest that the 60% EtOH extract of M. angustifolia has the potential to be developed as a treatment of AD. Furthermore, justicidin A may contribute, at least partially, to the Abeta alteration observed with the extract treatment.
5-Methoxyjusticidin A, a new arylnaphthalene lignan from Protium unifoliolatum.[Pubmed:9644067]
J Nat Prod. 1998 Jun 26;61(6):796-7.
A new arylnaphthalene lignan, 9-(1,3-benzodioxol-5-yl)-4,5,6, 7-tetramethoxynaphtho[2,3-C]furan-1(3H)-one (5-Methoxyjusticidin A, 1), was isolated from a Et2O extract of the wood of Protium unifoliolatum. The structure of 1 was determined by both spectroscopic and X-ray crystallographic methods.
