DiphyllinCAS# 22055-22-7 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 22055-22-7 | SDF | Download SDF |
| PubChem ID | 100492 | Appearance | Powder |
| Formula | C21H16O7 | M.Wt | 380.35 |
| Type of Compound | Lignans | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-3H-benzo[f][2]benzofuran-1-one | ||
| SMILES | COC1=C(C=C2C(=C1)C(=C3C(=C2O)COC3=O)C4=CC5=C(C=C4)OCO5)OC | ||
| Standard InChIKey | VMEJANRODATDOF-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C21H16O7/c1-24-15-6-11-12(7-16(15)25-2)20(22)13-8-26-21(23)19(13)18(11)10-3-4-14-17(5-10)28-9-27-14/h3-7,22H,8-9H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling. 2. Diphyllin has in vitro antileishmanial activity, it exerts a strong specific inhibitory activity (IC50 = 0.2 microM) resulting from the inhibition of parasite internalization within macrophages. 3. Diphyllin has anti-inflammatory activities, it shows 50% inhibition of NO production from peritoneal macrophages. |
| Targets | ATPase | Wnt/β-catenin | c-Myc | NO | TNF-α | IFN-γ | IL Receptor |
Diphyllin Dilution Calculator
Diphyllin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6292 mL | 13.1458 mL | 26.2916 mL | 52.5831 mL | 65.7289 mL |
| 5 mM | 0.5258 mL | 2.6292 mL | 5.2583 mL | 10.5166 mL | 13.1458 mL |
| 10 mM | 0.2629 mL | 1.3146 mL | 2.6292 mL | 5.2583 mL | 6.5729 mL |
| 50 mM | 0.0526 mL | 0.2629 mL | 0.5258 mL | 1.0517 mL | 1.3146 mL |
| 100 mM | 0.0263 mL | 0.1315 mL | 0.2629 mL | 0.5258 mL | 0.6573 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Effects of diphyllin as a novel V-ATPase inhibitor on gastric adenocarcinoma.[Pubmed:21645513]
Eur J Pharmacol. 2011 Sep 30;667(1-3):330-8.
The natural compound Diphyllin, a cytostatic lignan isolated from Cleistanthus collinus, can dramatically inhibit the proliferation and induce the apoptosis of human gastric cancer cells, SGC7901. Our study found that Diphyllin can inhibit the expression of V-ATPases in a dose-dependent manner, decrease the internal pH (pHi) and reverse the transmembrane pH gradient in SGC7901 cells. Changes of the pH gradient were positively correlated with Diphyllin concentration. Further study found that Diphyllin treatment caused a decrease in phospho-LRP6, but not in LRP6. beta-catenin in Wnt/beta-catenin signaling and its target genes, c-myc and cyclin-D1, were also decreased with the inhibition of V-ATPases. Therefore, Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/beta-catenin signaling.
Anti-inflammatory activities of constituents isolated from Phyllanthus polyphyllus.[Pubmed:16169167]
J Ethnopharmacol. 2006 Jan 16;103(2):181-6.
Four compounds, including one benzenoid, 4-O-methylgallic acid (1), together with three arylnaphthalide lignans, namely phyllamyricin C (2), justicidin B (3) and Diphyllin (4) were isolated from the whole plants of Phyllanthus polyphyllus L. (Euphorbiaceae). This was the first isolation report of compounds 1-4 from this plant species. The in vitro inhibitory effects of these compounds were evaluated on the production of nitric oxide (NO) and cytokines (tumor necrosis factor (TNF)-alpha and interleukin (IL)-12), from LPS/IFN-gamma activated murine peritoneal macrophages. The results indicated that the 50% inhibition concentration (IC(50)) values of NO production from activated peritoneal macrophages by compounds 1-4 were 100, 25, 12.5 and 50 microM, respectively. In parallel, these dilutions were approximately inhibited in a similar manner to that observed for cytokines (TNF-alpha, and IL-12) production. On the other hand, at 100 microM concentration compounds 3 and 4 showed 50% inhibition of NO production from peritoneal macrophages that had been pre-activated with LPS/IFN-gamma for 24h, whereas compounds 1 and 2 inhibited only about 20 and 10%, respectively. These results support the use of this plant for the treatment of inflammatory diseases in oriental traditional medicine.
