NG,NG-Dimethylarginine dihydrochlorideCAS# 220805-22-1 |
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| Cas No. | 220805-22-1 | SDF | Download SDF |
| PubChem ID | 16219246 | Appearance | Colorless cryst. |
| Formula | C8H20Cl2N4O2 | M.Wt | 275.18 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S)-2-amino-5-[[amino(dimethylamino)methylidene]amino]pentanoic acid;dihydrochloride | ||
| SMILES | CN(C)C(=NCCCC(C(=O)O)N)N.Cl.Cl | ||
| Standard InChIKey | SYLNVYJOPZWPJI-ILKKLZGPSA-N | ||
| Standard InChI | InChI=1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. NG,NG-Dimethylarginine dihydrochloride is a reversible inhibitor of nitric oxide synthetase in vivo and in vitro. |
| Targets | NO |
NG,NG-Dimethylarginine dihydrochloride Dilution Calculator
NG,NG-Dimethylarginine dihydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.634 mL | 18.1699 mL | 36.3399 mL | 72.6797 mL | 90.8496 mL |
| 5 mM | 0.7268 mL | 3.634 mL | 7.268 mL | 14.5359 mL | 18.1699 mL |
| 10 mM | 0.3634 mL | 1.817 mL | 3.634 mL | 7.268 mL | 9.085 mL |
| 50 mM | 0.0727 mL | 0.3634 mL | 0.7268 mL | 1.4536 mL | 1.817 mL |
| 100 mM | 0.0363 mL | 0.1817 mL | 0.3634 mL | 0.7268 mL | 0.9085 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure.[Pubmed:1347093]
Lancet. 1992 Mar 7;339(8793):572-5.
Nitric oxide (NO), synthesised from L-arginine, contributes to the regulation of blood pressure and to host defence. We describe in-vitro and in-vivo evidence that NO synthesis can be inhibited by an endogenous compound, NG,NG-dimethylarginine (asymmetrical dimethylarginine, ADMA). In man, this inhibitor is found in plasma and more than 10 mg is excreted in urine over 24 h. However, in patients with end-stage chronic renal failure, who have little or no urine output, elimination is blocked and circulating concentrations of the inhibitor rise sufficiently to inhibit NO synthesis. Accumulation of endogenous ADMA, leading to impaired NO synthesis, might contribute to the hypertension and immune dysfunction associated with chronic renal failure.
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