Clausine ECAS# 182261-83-2 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 182261-83-2 | SDF | Download SDF |
| PubChem ID | 5315951 | Appearance | Powder |
| Formula | C14H11NO3 | M.Wt | 241.2 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | methyl 1-hydroxy-9H-carbazole-3-carboxylate | ||
| SMILES | COC(=O)C1=CC2=C(C(=C1)O)NC3=CC=CC=C32 | ||
| Standard InChIKey | ZWPODTIRGFOENJ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C14H11NO3/c1-18-14(17)8-6-10-9-4-2-3-5-11(9)15-13(10)12(16)7-8/h2-7,15-16H,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Clausena excavata
| Description | 1. 2. | |||||
Clausine E Dilution Calculator
Clausine E Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.1459 mL | 20.7297 mL | 41.4594 mL | 82.9187 mL | 103.6484 mL |
| 5 mM | 0.8292 mL | 4.1459 mL | 8.2919 mL | 16.5837 mL | 20.7297 mL |
| 10 mM | 0.4146 mL | 2.073 mL | 4.1459 mL | 8.2919 mL | 10.3648 mL |
| 50 mM | 0.0829 mL | 0.4146 mL | 0.8292 mL | 1.6584 mL | 2.073 mL |
| 100 mM | 0.0415 mL | 0.2073 mL | 0.4146 mL | 0.8292 mL | 1.0365 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Identification of Clausine E as an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity.[Pubmed:31321808]
J Mol Recognit. 2019 Oct;32(10):e2800.
The alkaloids containing a carbazole nucleus are an established class of natural products with wide range of biological activities. A combination of thermodynamic and enzymatic activity studies provides an insight into the recognition of Clausine E by the fat mass and obesity-associated protein (FTO). The binding of Clausine E to FTO was driven by positive entropy and negative enthalpy changes. Results also indicated that the hydroxyl group was crucial for the binding of small molecules with FTO. The structural and thermodynamic information provides the basis for the design of more effective inhibitors for FTO demethylase activity.
Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres.[Pubmed:17548198]
Bioorg Med Chem. 2007 Aug 15;15(16):5615-9.
Aza-analogues of Clausine E, mukonine and koenoline were prepared from 1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde and their antiproliferative activity was evaluated against miscellaneous cancer cell lines and compared to those obtained with Clausine E and mukonine.
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